番木鳖碱置于甲基锂,Calcium Carbonate体系中,化学反应生成3-甲基吡啶 参考文献:Zur Kenntniss Des Strychnins 标题:Zur Kenntniss Des Strychnins 摘要: Doi:10.1007/bf01516731
专利信息
专利号:WO-2009018504-A1 优先权日:2007-08-01 标题 :Process for the synthesis of diaminopyridine and related compounds 发明人:RITTER JOACHIM C 权利人:DU PONT; RITTER JOACHIM C 摘要:A process is provided for the synthesis of a diaminopyridine, such as 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a chlorine-ammonia displacement in the presence of a copper source.
专利号:US-9388131-B2 优先权日:2011-04-27 标题:Automated synthesis of small molecules using chiral, non-racemic boronates 发明人:BURKE MARTIN D; LI JUNQI; GILLIS ERIC P 权利人:UNIV ILLINOIS 摘要:Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.
专利号:US-2024287520-A1 优先权日:2021-06-30 标题:Method for synthesis of linkage modified oligomeric compounds 发明人:RODRIGUEZ ANDREW A 权利人:IONIS PHARMACEUTICALS INC 摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.
专利号:US-2004242897-A1 优先权日:2002-07-31 标题 :Universal support media for synthesis of oligomeric compounds 发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH 摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.
专利号:US-2022401910-A1 优先权日:2019-12-02 标 题 :Apparatus for the synthesis of oligonucleotides and process for the preparation thereof 发明人:AEMISSEGGER ANDREAS; DUGOVIC BRANISLAV; JAUKER MARIO; STAUSS MARTIN 权利人:BACHEM AG 摘要:The present invention provides apparatuses and methods for the synthesis of oligonucleotides and related compounds. In particular, the present invention allows to effectively prepare reagents to be fed into an apparatus for the synthesis of such oligomers.
专利号:US-8084569-B2 优先权日:2006-12-21 标 题 :Process for the synthesis of diaminopyridines from glutarimidines 发明人:MINTER AARON; STOKES BERLIN 权利人:MINTER AARON; STOKES BERLIN; DU PONT 摘要:A liquid-phase process is provided for the synthesis from glutarimidines of diaminopyridines and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.
参考标题:Synthesis Of Mixed α/β2,2-Peptides By Site-Selective Ring-Opening Of Cyclic Quaternary Sulfamidates 作者:Nuria Mazo,Iván García-González,Claudio D. Navo,Francisco Corzana,Gonzalo Jiménez-Osés,Alberto Avenoza,Jesús H. Busto,Jesús M. Peregrina |发布日期:2015.12.4 摘要:Derived From 2-Methylisoserine, Has Been Generalized. The Unique Electrophilic Nature Of This Scaffold For Nucleophilic Substitution At A Quaternary Center With Total Inversion Of Its Configuration, Which Was Demonstrated Computationally, Allows For Site-Selective Conjugation With Various Nucleophiles, Such As Anomeric Thiocarbohydrates And Pyridines. This Strategy Provides Rapid Access To Complex Thio
合成参考文献
参考文献:10.1107/s1600536811019076 摘要:Kim YI, Lim HS, Kang SK. Bis(3-methyl-pyridinium) tetra-(chlorido/bromido)cuprate(II). Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 01;67(Pt 6):m793–4.