CAS: 936-58-3; 1-Phenyl-3-Buten-1-Ol

该化合物是有机化合物,其独特结构包括一个附于丁醇协会的联苯组,该化合物一般是清黄液体的无色,因其芳香特性而闻名;其结构的丁醇部分具有双重结合,有助于其再活动,并有可能应用于有机合成;4-phenyl-1-buten-4-ol的氢氧(-OH)组,使其成为酒精,允许其参与各种化学反应,例如脱水和化毒剂;该化合物在有机化学和材料科学领域很感兴趣,特别是有可能用于合成更为复杂的分子;此外,其物理特性,如沸点和溶解性,可因环境条件和纯度而有所变化;在处理该化合物时,应采用安全防范措施,如许多有机化学品.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

allyl iodid benzaldehyde allyl bromide allylmagnesium bromide 4-tert-Butylphosphanyl-1-phenyl-butan-1-ol 4-(tert.-Butylamino)-1-phenyl-1,3-butandiol 4-(1,1-dimethylethylthio)-1-phenyl-1-butanol 3-hydroxy-3-phenylhexa-1,5-diene

合成工艺路线路线简述

  • 100-52-7 = 936-58-3
    反应条件:1.1 Reagents: Magnesium,Iodine Solvents: Tetrahydrofuran,Water
    标题:Magnesium-Mediated Carbon-Carbon Bond Formation In Aqueous Media: Barbier-Grignard Allylation And Pinacol Coupling Of Aldehydes
    作者:Zhang,Wen-Chun; Li,Chao-Jun
    参考文献:Journal Of Organic Chemistry 日期:1999 卷标:64(9) 页码:3230-3236]

    100-52-7 + 1730-25-2 = 936-58-3
    反应条件:1.1 Solvents: Diethyl Ether; 10 Min,0 °C; 2 - 3 H,0 °C1.2 Reagents: Ammonium Chloride Solvents: Water; 10 Min,0 °C
    标题:Double Prins Cyclisation Enabled Rapid Access To α,ω-Hydroxytetrahydropyrans
    作者:Trevorrow,Jonathan; O'Kearney-Mcmullan,Anne; Miller Potucka,Lucie; Dobbs,Adrian P.
    参考文献:European Journal Of Organic Chemistry 日期:2022 卷标:2022(40)]

    100-52-7 = 936-58-3
    反应条件:1.1 Reagents: Zinc Solvents: Tetrahydrofuran; 4 H,Rt
    标题:Bronsted Acid-Mediated Domino One-Pot Dual C-C Bond Formation: Chemoselective Synthesis Of Fused Tricyclic Ketones
    作者:Niharika,Pedireddi; Ramulu,Bokka Venkat; Satyanarayana,Gedu
    参考文献:Acs Omega 日期:2018 卷标:3(1) 页码:218-228]

    100-52-7 = 936-58-3
    反应条件:1.1 Reagents: Tin Catalysts: Ammonium Nitrate,Silver Nitrate Solvents: Water; 3 H,Rt
    标题:Silver-Tin Mediated Allylations In Aqueous Media
    作者:Andreiadis,Eugen; Marton,George; Marton,Anca
    参考文献:Revue Roumaine De Chimie 日期:2006 卷标:51(7-8) 页码:629-634]

    100-52-7 = 936-58-3
    反应条件:1.1 Catalysts: Tetraphenylporphyrin,Palladium Diacetate Solvents: Water; 30 Min,Rt1.2 Reagents: Indium Bromide (Inbr); 4.5 H,Rt
    标题:Investigation Of The Aqueous Transmetalation Of π-Allylpalladium With Indium Salt: The Use Of The Pd(Oac)2-Tppts Catalyst
    作者:Fontana,Gianfranco; Lubineau,Andre; Scherrmann,Marie-Christine
    参考文献:Organic & Biomolecular Chemistry 日期:2005 卷标:3(8) 页码:1375-1380]

    100-52-7 = 936-58-3
    反应条件:1.1 Reagents: Stannous Chloride Solvents: Water; 10 H,Rt
    标题:A Recyclable Electrochemical Allylation In Water
    作者:Zha,Zhenggen; Hui,Ailing; Zhou,Yuqing; Miao,Qian; Wang,Zhiyong; Et Al
    参考文献:Organic Letters 日期:2005 卷标:7(10) 页码:1903-1905]

    100-52-7 = 936-58-3
    反应条件:1.1 Reagents: Tin Solvents: Water; 6 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Barbier-Type Reaction Mediated With Tin Nano-Particles In Water
    作者:Zha,Zhenggen; Qiao,Shu; Jiang,Jiaoyang; Wang,Yusong; Miao,Qian; Et Al
    参考文献:Tetrahedron 日期:2005 卷标:61(9) 页码:2521-2527]

    100-52-7 = 936-58-3
    反应条件:1.1 Reagents: Magnesium Solvents: Tetrahydrofuran,Water1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Unexpected Barbier-Grignard Allylation Of Aldehydes With Magnesium In Water
    作者:Li,Chao-Jun; Zhang,Wen-Chun
    参考文献:Journal Of The American Chemical Society 日期:1998 卷标:120(35) 页码:9102-9103]

    100-52-7 + 74348-96-2 = 936-58-3
    反应条件:1.1 Catalysts: Dinaphtho[2,1-D:1′,2′-F][1,3,2]Dioxaphosphepin,4-Hydroxy-2,6-Bis[2,4,6-Tris(1-M... Solvents: Toluene; Rt
    标题:Bi(Cyclopentyl)Diol-Derived Boronates In Highly Enantioselective Chiral Phosphoric Acid-Catalyzed Allylation,Propargylation,And Crotylation Of Aldehydes
    作者:Yuan,Jinping; Jain,Pankaj; Antilla,Jon C.
    参考文献:Journal Of Organic Chemistry 日期:2020 卷标:85(20) 页码:12988-13003]

    100-52-7 + 1730-25-2 = 936-58-3
    反应条件:1.1 Solvents: Diethyl Ether; 0 °C; Rt1.2 Reagents: Ammonium Chloride Solvents: Water; Rt
    标题:Copper-Catalyzed One-Pot Borylative Aldolisation β-Fluoride Elimination For The Formal Addition Of Acrylates To Carbonyl Moieties
    作者:Rasson,Corentin; Stouse,Adrien; Boreux,Arnaud; Cirriez,Virginie; Riant,Olivier
    参考文献:Chemistry - A European Journal 日期:2018 卷标:24(37) 页码:9234-9237]

    100-52-7 + 591-87-7 = 936-58-3
    反应条件:1.1 Reagents: Triethylamine,Carbon Monoxide Catalysts: Ruthenium Trichloride Solvents: 1,4-Dioxane,Water; 18 H,90 Psi,70 °C
    标题:Catalytic Nucleophilic Allylation Driven By The Water-Gas Shift Reaction
    作者:Denmark,Scott E.; Matesich,Zachery D.; Nguyen,Son T.; Milicevic Sephton,Selena
    参考文献:Journal Of Organic Chemistry 日期:2018 卷标:83(1) 页码:23-48]

    100-52-7 = 936-58-3
    反应条件:1.1 Reagents: Zinc Solvents: Tetrahydrofuran; Cooled; 1 H,Cooled1.2 Solvents: Tetrahydrofuran; Cooled; 1.5 H,Cooled
    标题:Synthesis Of 4-Aminotetrahydropyran Scaffolds For Drug Discovery
    作者:Nortcliffe,Andrew; Milne,Gavin D. S.; Hamza,Daniel; Moody,Christopher J.
    参考文献:Bioorganic & Medicinal Chemistry 日期:2017 卷标:25(7) 页码:2218-2225]

    100-52-7 = 936-58-3
    反应条件:1.1 Solvents: Chloroform; Reflux
    标题:Triethylammonium Bis(Catecholato)Allylsiliconate
    作者:Hosomi,Akira; Miura,Katsukiyo
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 卷标:1 页码:1-2]

    100-52-7 + 1730-25-2 = 936-58-3
    反应条件:1.1 Solvents: Tetrahydrofuran
    标题:Palladium(0)-Mediated Cyclization-Coupling Of β,γ-Unsaturated Oximes And Aryl Iodides
    作者:Mikesell,Joshua; Mosher,Michael D.
    参考文献:Tetrahedron Letters 日期:2016 卷标:57(9) 页码:1011-1013]

    100-52-7 = 936-58-3
    反应条件:1.1 Reagents: Tin Solvents: 1-Butyl-3-Methylimidazolium Tetrafluoroborate; 24 H,Rt
    标题:Tin Mediated Barbier Type Allylation In Ionic Liquids
    作者:Slaton,Rahiem; Petrone,Adam; Manchanayakage,Renuka
    参考文献:Tetrahedron Letters 日期:2011 卷标:52(39) 页码:5073-5076]

    100-52-7 = 936-58-3
    反应条件:1.1 Reagents: Aluminum Catalysts: Indium Trichloride Solvents: Water,1-Butyl-3-Methylimidazolium Hexafluorophosphate; 30 Min,Rt
    标题:Ionic Liquid-Accelerated Allylation Of Carbonyl Compounds With A Catalytic Amount Of Indium Generated From In Situ Reduction Of Incl3 With Aluminum
    作者:Hirashita,Tsunchisa; Sato,Yuki; Yamada,Dai; Takahashi,Fusako; Araki,Shuki
    参考文献:Chemistry Letters 日期:2011 卷标:40(5) 页码:506-507]

    7393-43-3 + 100-52-7 = 936-58-3
    反应条件:1.1 Catalysts: 10H,12H-[2,1]Benzazastibolo[1,2-A][2,1]Benzazastibolium,11-Methyl-,Hexafluorop...; 5 Min,Rt1.2 3 H,25 °C
    标题:Organoantimony Ionic Compound Containing Bridge-Type Nitrogen Atom Ligand,Its Preparation Process And Application
    参考文献:China]

    7393-43-3 + 100-52-7 = 936-58-3
    反应条件:1.1 Catalysts: 10H,12H-[2,1]Benzazabismolo[1,2-A][2,1]Benzazabismolium,1,2,3,4,6,7,8,11-Octame...; 5 Min,Rt1.2 3 H,25 °C
    标题:Organic Bismuth Ion Compounds Containing Bridging Nitrogen Ligand,Their Preparation Method And Application As Catalyst In Allylation Of Aldehyde
    参考文献:China]

    100-52-7 + 1730-25-2 = 936-58-3
    反应条件:1.1 Solvents: Diethyl Ether; 0 °C -> Rt
    标题:Total Synthesis Of (+/-)-Diospongin A Via Prins Reaction
    作者:Hiebel,Marie-Aude; Pelotier,Beatrice; Piva,Olivier
    参考文献:Tetrahedron 日期:2007 卷标:63(33) 页码:7874-7878]

    100-52-7 = 936-58-3
    反应条件:1.1 Reagents: Indium Solvents: Dimethylformamide; 5 - 30 Min,40 - 50 °C
    标题:Granular Indium Barbier Allylation Of Carbonyl Compounds: A More Economical Protocol
    作者:Preite,Marcelo D.; Perez-Carvajal,Andres
    参考文献:Synlett 日期:2006 卷标:(19) 页码:3337-3339

海关参考信息

专利信息


专利号:WO-2016120890-A1
优先权日:2015-01-30
标题 :An enantioselective process for the synthesis of (2s,4r)-4-hydroxypipecolic acid
发明人：SURYAVANSHI GURUNATH; KAMBLE ROHIT BALKRISHNA
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to an improved process for synthesis of 4-hydroxy pipecolic acid. The present invention relates to an improved enantioselective process for the synthesis of (2S,4R)-4-hydroxypipecolic acid via Co(III) (salen)-catalyzed two stereocentered Hydrolytic Kinetic Resolution (HKR) of racemic 1,3-azido epoxide with good yields and high optical purity without any protecting groups. 10 31

专利号:US-5618944-A
优先权日:1993-05-05
标题:Method for the synthesis of anthrapyrazolones
发明人：ZHANG LIN-HUA; AUERBACH JOSEPH
权利人:DU PONT MERCK PHARMA
摘要:This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphenyl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.

专利号:US-9243004-B2
优先权日:2011-07-22
标题 :Synthesis of boronic esters and boronic acids using grignard reagents
发明人：CLARY JACOB W; SINGARAM BAKTHAN
权利人:CLARY JACOB W; SINGARAM BAKTHAN; UNIV CALIFORNIA
摘要:Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg 0 . When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.

专利号:US-2007225490-A1
优先权日:2003-12-15
标 题:Cationic Oligomer of a Saccharide for Resolving Enantiomers and Asymmetric Synthesis
发明人：CHING CHI B; YOUNG DAVID J; MUDERAWAN I WAYAN; ONG TENG T; NG SIU C
权利人:SELEX SENSORS & AIRBORNE SYS
摘要:A cationic oligomer of a saccharide, wherein the saccharide is functionalized by a cationic group, for example an ammonium, phosphonium, imidazolium, or pyridinium group. In a preferred embodiment, the cationic oligomer of a saccharide is a cationic cyclodextrin. There is also provided a use of the cationic oligomer of a saccharide as a chiral agent for resolving enantiomers by a chromatographic method or an asymmetric synthesis.

专利号:US-8263774-B2
优先权日:2009-09-03
标题:Quinoline-oxazoline compounds and their use in oxidation synthesis
发明人：SIGMAN MATTHEW SCOTT; MICHEL BRIAN WILLIAM
权利人:SIGMAN MATTHEW SCOTT; MICHEL BRIAN WILLIAM; UNIV UTAH RES FOUND
摘要:A quinoline-oxazoline compound having the formula: n n n n n n n n n n n n where one of X 1 and X 2 is N and the other is C and one of R1, R2 and R3 is Z wherein Z is an oxazoline radical having the formula n n n n n nsuch that when X 1 is N R2 is Z and R1 is absent, and when X 2 is N either R1 or R3 is Z and R2 is absent. R1 and R3 through R12 are independently H or a pendant moiety which does not interfere with coordination of either N in the quinoline compound with a coordination center. These compounds can be complexed with a suitable coordination center such as catalytically active palladium and can be highly useful in catalytically oxidizing alkenes with high regioselectivity.

专利号:WO-02051883-A1
优先权日:2000-12-26
标题:Synthesis of novel heterocyclic molecules oxygenated by metathesis reaction on solid support using novel silylated linkers

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合成参考文献


摘要:Diver, S. T., Science of Synthesis, (2009) 46, 102.
摘要:Chciuk, T. V.; Flowers, R. A.; Flowers, R. A., Science of Synthesis Knowledge Updates, (2016) 2, 256.
摘要:Okamoto, K.; Ohe, K., Science of Synthesis Knowledge Updates, (2020) 1, 89.
摘要:Snaith, J. S., Science of Synthesis Knowledge Updates, (2011) 2, 208.
摘要:Araki, S.; Hirashita, T., Science of Synthesis Knowledge Updates, (2010) 4, 128.
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