CAS: 84-55-9; 1-(6-Methoxyquinolin-4-yl)-3-((3R,4R)-3-Vinylpiperidin-4-yl)Propan-1-One
该化合物是一种结构复杂的有机化合物,其结构上由六方的甲氧基组和与(3R,4R)-3-氯基丙基-4-yl组相连的丙基-1-1-oe酸基替代的丙基基核心,该化合物对药用化学很感兴趣,因为它在药物发现中具有合成中间体或药用磷的潜力.
- 英文名称1-(6-Methoxyquinolin-4-yl)-3-((3R,4R)-3-Vinylpiperidin-4-yl)Propan-1-One
- 中文名称维喹地尔
- IUPAC名称1-(6-methoxyquinolin-4-yl)-3-((3R,4R)-3-vinylpiperidin-4-yl)propan-1-one
- 其它别名1-(6-Methoxy-4-Quinolyl)-3-[(3R,4R)-3-Vinyl-4-Piperidinyl]-1-Propanone; Chinicine; Quinotoxine; Quinotoxol; 1-(6-Methoxy-4-Quinolyl)-3-[(3R,4R)-3-Vinyl-4-Piperidyl]Propan-1-One; 3-[(3R,4R)-3-Ethenylpiperidin-4-Yl]-1-(6-Methoxyquinolin-4-Yl)Propan-1-One; D-Quinotoxine; 1-(6-Methoxyquinolin-4-Yl)-3-((3R,4R)-3-Vinylpiperidin-4-Yl)Propan-1-One
- CAS编号84-55-9
- MFCD编号:MFCD24682725
- EINECS号:201-540-1
- FDA UNII编号:48T4S8667S
- 分子式:C20H24N2O2分子量:324.42
- 产品CID: 1834424
- 产品分类有机原料 → 有机杂环化合物 → 喹啉及其衍生物
物理性质
MSDS等安全信息
上下游产品
CAS号86-68-0 6-甲氧基喹啉-4-甲酸 | CAS号87-69-4 酒石酸合成工艺路线路线简述
- 合成目标产物 Viquidil 主要起始原料 Quinine
- (文献来源)合成步骤主要原料 Quinine
📜奎尼丁置于氢氧化钾,乙酸酐,溶剂黄146体系中,用 甲醇,乙醇 作为反应溶剂,化学反应 99.0H,反应生成 维喹地尔
参考文献:乙酸催化的金鸡纳生物碱的立体特异性差向异构,氧化和毒素重排
标题:乙酸催化的金鸡纳生物碱的立体特异性差向异构,氧化和毒素重排
摘要:冰醋酸在c-9催化了金鸡纳生物碱的新的立体定向差向异构化.在水的存在下,醋酸还催化了已知的毒素重排和氧化为相应的9-酮衍生物.将乙酸酐添加到乙酸中可减少c-9处的氧化和差向异构,主要产物是水胺裂变的结果.只有丙酸而不是其他酸发生相似但不相同的转化.少量添加H2O 2或排除氧气会分别产生定量的氧化和重排产物.乙酸水溶液的催化作用涉及三元环中间体形成过程中的c-9-Oh.另一方面,在无水乙酸的情况下,G-9处的乙酰氧基参与了五元环中间体的构建.在这两种情况下,反应似乎都是分子内的.通过分离衍生自奎尼丁的季铵盐,为所提出的机理提供了支持,该结构的结构也通过x射线衍射分析进行了表征.乙酸水溶液催化这种盐重排为相应的毒素.在天然生物碱的使用条件下均未观测到氧化或差向异构.
DOI:10.1016/s0040-4020(01)90029-8
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905110000-甲醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications
专利号:AU-2007308022-B2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Guérémy C, Uzan A, Tamen JC. [Viquidil: study of metabolism using the isotope method. I. Synthesis of 14C-labelled viquidil]. Arzneimittelforschung. 1972 Aug;22(8):1336-40. French. German. French. French. French. Italian. French. French. Polish. French.
合成参考文献
参考文献:10.1007/978-3-663-01938-1_5
📝 需求与反馈
尽可能描述清楚需求与问题信息
