CAS: 826-39-1; N,2,3,3-Tetramethylbicyclo[2.2.1]Heptan-2-Amine Hydrochloride

📜(+/-)-Mecamylamine 在 Sodium Ethanolate体系中,用 乙醇,氯仿作为反应溶剂,反应 1.0H,获得 (+/-)-Exo-Mecamylamine hydroChloride
参考文献:通过(甲基苄基)脲类似物的热分解制备旋光性仲胺:(+)-和(-)-美甲胺的绝对构型.初步沟通† ‡
标题:通过(甲基苄基)脲类似物的热分解制备旋光性仲胺:(+)-和(-)-美甲胺的绝对构型.初步沟通† ‡
摘要:(+/-)-美甲胺((+/-)-1)的(α-甲基苄基)脲非对映异构体4和5和(+/-)-1-去甲甾氨酸o-甲基醚((+/-)-3)的6和7的热解.回流的醇除了可以循环利用的(α-甲基苄基)胺的光学纯氨基甲酸酯外,还以高收率提供了光学纯的胺.通过x射线衍射分析来确定(-)-甲酰胺胺盐酸盐((-)-1 .Hcl)的绝对构型.
Doi:10.1002/Hlca.19860690205

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2003138880-A1
优先权日:2001-08-24
标 题:Solid-phase synthesis of oligosaccharides and glycopeptides using glycosynthases
发明人：WITHERS STEPHEN G; JENSEN KNUD J; PETERSEN LARS; TOLBORG JAKOB L
权利人:UNIV BRITISH COLUMBIA
摘要:The present invention provides materials and methods for the solid-phase synthesis of oligosaccharides and glycopeptides. Such materials and methods include mutant glycosidase enzymes, or “glycosynthases,â€? chemically-derivatized acceptor molecules, and specific solid support matrices.

专利号:US-2008300418-A1
优先权日:2004-11-08
标 题:Synthesis of Cardiolipin Analogues and Uses Thereof
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
权利人:AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
摘要:The invention provides novel synthetic methodologies for preparing cardiolipin, migrated caridiolipin (1,2-positional isomer of cardiolipin) and their analogues having varying fatty acids and/or alkyl chains with varying length and degrees of saturation/unsaturation. The method comprises (a) reacting an optically pure 1,2-O-dialkyl-sn-glycerol or 1,2-O-dialkyl-sn-glycerol with one or more phosphoramidite reagent(s), wherein a phosphite triester is produced; (b) coupling the product of (a) with glycerol, wherein a protected cardiolipin is produced; and (c) deprotecting the protected cardiolipin, such that cardiolipin is prepared. The cardiolipins and analogues thereof, prepared by the present methods, can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs, antisense nucleotides or diagnostic agents. Such liposomes can be used to treat diseases or can be used in diagnostic and/or analytical assays.

专利号:US-2006078560-A1
优先权日:2003-06-23
标 题 :Method of inducing apoptosis and inhibiting cardiolipin synthesis
发明人：JAMIL HARIS; AHMAD MOGHIS U; AHMAD IMRAN
权利人:NEOPHARM INC
摘要:The present invention provides a method for inducing apoptosis within a cell by exposing the cell to an inhibitor of cardiolipin synthesis under conditions sufficient to induce apoptosis within the cell. The method can be used to investigate or treat disorders such as cancer, obesity, and cardiovascular disorders. The invention also provides a pharmaceutical composition including an inhibitor of cardiolipin synthesis and a liposomal carrier.

专利号:US-2008286351-A1
优先权日:2004-06-29
标 题:Pegylated Cardiolipin Analogs, Methods of Synthesis, and Uses Thereof
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
权利人:AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
摘要:The invention provides synthetic methods for PEGylated cardiolipins with varying linkers. The methods can be employed to prepare PEGylated cardiolipin with different fatty acid and/or alkyl chain length with or without unsaturation. The PEGylated cardiolipin, prepared by the present methods, can be incorporated into liposomes that can also include active agents such as hydrophilic or hydrophobic drugs for the treatment of human and animal diseases. In addition, the PEGylated cardiolipin can be incorporated into liposomes that include compounds for therapeutic and diagnostic imaging. The use of such liposomes with PEGylated cardiolipin prolongs the period of liposomal circulation without disrupting the lipid bilayer.

专利号:US-2005266068-A1
优先权日:2002-05-24
标题 :Cardiolipin molecules and methods of synthesis
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; AHMAD IMRAN
权利人:NEOPHARM INC
摘要:The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation, particularly a short-chain cardiolipin. The methods comprise reacting a 1,2-O-sn-diacyl/1,2-O-sn-dialkyl glycerol or a 2-O-protected glycerol, with a phosphoramidite reagent or a phosphate triester to produce a protected cardiolipin, which is deprotected to prepare the short chain cardiolipin. The reaction schemes can be used to generate new variants of cardiolipin. The cardiolipin prepared by the present methods can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs. Such liposomes can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes can also include ligands for targeting a particular cell type or specific tissue.