CAS: 816-40-0; 1-Bromobutan-2-One

该化合物是一种溴化的氯酮化合物,通常用作有机合成的中间体,其反应性α-溴碳基化合物对核嗜血性替代反应很有价值,能够将丁烷酮衍生功能引入目标分子,该化合物在制药和农用化学研究中特别有助于建筑复杂结构,在受控制条件下的适度波动和稳定性有利于实验室环境的处理.必须谨慎对待,因为其乳胶特性和皮肤可能刺激.建议在与该试剂合作时适当储存在冷干环境中,并使用个人防护设备.

结构式图片

相似化合物

134833-83-3 2482-57-7 19967-55-6

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

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合成工艺路线路线简述

    📜3-氯-2-丁酮置于sodium Bromide体系中,用 N-甲基乙酰胺 作为反应溶剂,化学反应生成 溴丁酮
    参考文献:Process For Preparing A Substituted Imidazopyridine Compound
    标题:Process For Preparing A Substituted Imidazopyridine Compound
    摘要:本发明提供了一种新的大规模制备配体式为(1)的取代咪唑吡啶化合物的工艺,其中r1是c1-C6烷氧基或nh2基团,包括将式(2)的化合物与3-卤代-2-丁酮在环己酮中反应的步骤.

    海关参考信息

    专利信息


    专利号:US-9556140-B2
    优先权日:2013-01-26
    标 题 :Approach for synthesis of catechins
    发明人:DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH
    权利人:SPHAERA PHARMA PRIVATE LTD
    摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

    专利号:US-6455680-B1
    优先权日:2000-12-21
    标 题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
    发明人:LUKIN KIRILL A
    权利人:ABBOTT LAB
    摘要:An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.

    专利号:US-9428482-B2
    优先权日:2011-01-27
    标 题 :Process for synthesis of polyphenols
    发明人:DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE
    权利人:DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE; SPHAERA PHARMA PTE LTD
    摘要:The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives. A principle objective of the disclosure is to provide a new and useful method of synthesis to obtain polyphenols in isomerically pure and/or racemic forms.

    专利号:US-2024400552-A1
    优先权日:2016-11-11
    标题 :Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-11622968-B2
    优先权日:2011-03-08
    标 题:Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-11034690-B2
    优先权日:2016-11-11
    标 题:Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Erin F Dimauro, Et Al. Microwave-Assisted Preparation Of Fused Bicyclic Heteroaryl Boronates: Application In One-Pot Suzuki Couplings. J Org Chem. 2006 May 12;71(10):3959-62.

    合成参考文献


    摘要:Yoshida, H., Science of Synthesis Knowledge Updates, (2022) 3, 9.
    摘要:Shimada, K., Science of Synthesis Knowledge Updates, (2010) 1, 419.
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