CAS: 79874-76-3; Delmopinol
该化合物是一种化学化合物,主要被确认用于口腔卫生产品,特别是作为口水和牙科液中的一种活性成分,被归类为表面活性剂和显微性能,能够有效减少红斑形成和腺炎;Delmopinol功能,通过干扰口腔细菌的生物胶片形成,从而增进口腔健康;该化合物通常被描述为无色至黄色的黄色液体,在水和酒精中溶解,便于将其纳入水溶剂;其行动机制包括改变细菌膜表面的紧张状态,导致细胞的透析,降低细菌的存活能力;Delmopinol一般被视为牙科护理产品安全,在按原样使用时,具有有利的安全性特征;此外,已经研究过它在其他治疗领域的潜在好处,尽管它的主要用途仍在牙科中.
物理性质
- 沸点374.6±22.0 °C at 760 mmHg
- 闪点180.3±22.3 °C
- 密度0.9±0.1 g/cm3
- pKa:14.90±0.10(预测)
- PSA:32.7
- LogP:4.49
- 折射率1.463
- 蒸汽压0.0±1.9 mmHg at 25°C
- 溶解性水:0.2(Max Conc. mg/mL);0.74(Max Conc. mM)
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物用于治疗用途和生物研究,研究其对牙齿板生物膜中的酸适应和酸生产的影响和氟化物.
上下游产品
CAS号79874-63-8 3-(4-propyl-hep... | CAS号594-01-4 1-chloroethanol | CAS号98092-92-3 2-[3-(4-Propylh...合成工艺路线路线简述
海关参考信息
- 2905121000-正丙醇
2905130000-正丁醇
2909110000-乙醚
2922110001-单乙醇胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:RU-2042670-C1
优先权日:1989-05-24
标 题 :Method of synthesis of delmopinol and isoxazoleimidine derivatives
专利号:US-11229591-B2
优先权日:2018-12-21
标 题:Methods for synthesizing zinc-lysine-chloride complex
发明人：JARACZ STANISLAV; PAN LONG
权利人:COLGATE PALMOLIVE CO
摘要:Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride with a slight molar excess of amino acid hydrohalide, as well as oral care compositions comprising said complexes made according to said method.
专利号:US-11117906-B2
优先权日:2018-12-21
标题:Methods for synthesizing zinc-lysine-chloride complex
发明人：HAO ZHIGANG; CHENG CHI-YUAN; BRINZARI TATIANA; PAN LONG; SUBRAMANYAM RAVI; EVANS LAUREN; LEITE SERGIO
权利人:COLGATE PALMOLIVE CO
摘要:Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
专利号:US-11091502-B2
优先权日:2018-12-21
标 题:Methods for synthesizing zinc-lysine-chloride complex
发明人：HAO ZHIGANG; CHENG CHI-YUAN; BRINZARI TATIANA; PAN LONG; SUBRAMANYAM RAVI
权利人:COLGATE PALMOLIVE CO
摘要:Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc halide and amino acid free base in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
专利号:US-10857083-B2
优先权日:2017-12-19
标题 :Amino acid carbamate complexes
发明人：PAN LONG; WU DONGHUI; SUBRAMANYAM RAVI; SHEN HONGWEI; CHENG CHI-YUAN; BRINZARI TATIANA
权利人:COLGATE PALMOLIVE CO
摘要:Disclosed herein are amino acid carbamate complexes, methods of synthesis thereof, oral care compositions comprising the same, and methods of making and using thereof.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Sjödin T, Movert R, Åström M. Reduced Use of Antibiotics and Nasal Decongestants During Treatment with a Mouthwash Containing Delmopinol. Oral Health Prev Dent. 2023 Nov 2;21:347-356. doi: 10.3290/j.ohpd.b4586769. 76(4):ovad042. doi: 10.1093/lambio/ovad042. 106(3):778-785. doi: 10.1093/jaoacint/qsad003. 24(2):80-84. 60(9):880-886. doi: 10.1093/chromsci/bmab133. 49(1):28-38. doi: 10.1111/jcpe.13566. Epub 2021 Nov 3.
7: Komine A, Yamaguchi E, Okamoto N, Yamamoto K. Virucidal activity of oral care products against SARS-CoV-2 in vitro. J Oral Maxillofac Surg Med Pathol. 2021 Jul;33(4):475-477. doi: 10.1016/j.ajoms.2021.02.002. Epub 2021 Feb 22.
8: Sjödin T, Diogo Löfgren C, Glantz PO, Christersson C. Delmopinol - adsorption to and absorption through the oral mucosa. Acta Odontol Scand. 2020 Nov;78(8):572-579. doi: 10.1080/00016357.2020.1758772. Epub 2020 Apr 29. 47(7):883-891. doi: 10.1111/jcpe.13295. Epub 2020 May 27.
合成参考文献
参考文献:10.4103/0970-9290.199602
摘要:LuIs HS, Luis LS, Bernardo M. In vitro study of the effect of an essential oil and a delmopinol mouth rinse on dental plaque bacteria. Indian J Dent Res. 2016 Nov;27(6):648–51. doi: 10.4103/0970-9290.199602.
参考文献:10.1902/jop.1992.63.7.618
摘要:Collaert B, Edwardsson S, Attström R, Hase JC, Aström M, Movert R. Rinsing with delmopinol 0.2% and chlorhexidine 0.2%: short-term effect on salivary microbiology, plaque, and gingivitis. J Periodontol. 1992 Jul;63(7):618–25. doi: 10.1902/jop.1992.63.7.618.
参考文献:10.1111/j.1600-051x.1992.tb00653.x
摘要:Rundegren J, Hvid EB, Johansson M, Aström M. Effect of 4 days of mouth rinsing with delmopinol or chlorhexidine on the vitality of plaque bacteria. J Clin Periodontol. 1992 May;19(5):322–5. doi: 10.1111/j.1600-051x.1992.tb00653.x.
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