CAS: 752-61-4; Digitalin

该化合物是来自Digitalis工厂叶叶子的心球,通常称为狐狸球,主要用于治疗心脏状况,特别是心脏衰竭和小发性纤维化,因为它能够增加心脏萎缩的力量,调节心脏节奏.复合物呈现出一种复杂的结构,其特点是多糖糖糖核,具有多种糖糖味,有助于其溶解和生物活动.数字化行为抑制纳+/K+ ATPase酶,导致细胞内钠和钙浓度增加,最终增加心脏紧凑性.其药用动力学可以因配方和病人新陈代谢等因素而变化,而且它有一个狭窄的治疗窗口,需要仔细监测血液水平以避免毒性.常见副作用包括胃肠扰动,视觉变化和心律.与其他心脏晶质一样,使用数字化素需要谨慎,特别是在肾损伤或电解失调的病人中.

结构式图片

MSDS等安全信息

    上下游产品

    Gitoxigenin 3-O-β-D-Glucopyranosyl-(1→3)-β-D-Glucopyranosyl-(1→4)-β-D-Digitalopyranoside

    合成工艺路线路线简述

      📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于enzyme-Substance From Euhadra Quaesita体系中,化学反应生成 毛地黃苷
      参考文献:Okano,Chemical And Pharmaceutical Bulletin,1958,Vol. 6,P. 178,180
      标题:Okano,Chemical And Pharmaceutical Bulletin,1958,Vol. 6,P. 178,180

      海关参考信息

      专利信息


      专利号:US-10925977-B2
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
      发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
      权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
      摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

      专利号:WO-9925385-A1
      优先权日:1997-11-17
      标 题:A method of increasing nucleic acid synthesis with ultrasound
      发明人:UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
      权利人:IMARX PHARMACEUTICAL CORP
      摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.

      专利号:US-12231145-B1
      优先权日:2022-02-24
      标 题 :Systems and methods for digital signal synthesis with variable sample rate DAC
      发明人:YU TOMMY; MADISETTI AVANINDRA
      权利人:MIXED SIGNAL DEVICES INC
      摘要:Systems and methods for digital signal synthesis with variable sample rate digital-to-analog converters (DACs) in accordance with various embodiments of the invention are described. One embodiment includes a digital frequency generator that includes a direct digital frequency synthesizer (DDFS); a digital-to-analog converter (DAC); a frequency/phase estimation circuit; a stable reference clock (REF CLK); a variable frequency sample clock; a frequency control word (FCW); where the DAC is sampled by the variable frequency sample clock; where the DDFS is clocked by the variable frequency sample clock; where the frequency/phase estimation circuit receives as inputs the stable REF CLK and the variable frequency sample clock and estimates a FCW frequency error and adjusts the FCW to the DDFS; where the DDFS receives the FCW and outputs a digital sine codeword at the variable frequency sample clock to the DAC, where the FCW to the DDFS is continuously adjusted to track the variable frequency sample clock.

      专利号:US-10814013-B2
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:AU-2007308022-A2
      优先权日:2006-10-05
      标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:AU-2007308022-A1
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

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      合成参考文献


      摘要:Journal of Pharmacology and Experimental Therapeutics., 111(365), 1954 []
      摘要:Die Herzwirksamen Glykoside, Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963, -(44), 1963
      摘要:HAZARD R, HAZARD J, THOUVENOT J. [Diminution of sensitivity to digitalin by rubidium chloride; analogies with potassium]. C R Seances Soc Biol Fil. 1957;151(12):2049–50.
      摘要:ERJAVEC F, ARNOULD P. [Effect of hemorrhage & ligation of portal vein on the lethal dose of digitalin & lanatoside C in guinea pig]. C R Seances Soc Biol Fil. 1958;152(5):820–2.
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