专利号:US-10925977-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications 发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S 权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS 摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:WO-9925385-A1 优先权日:1997-11-17 标 题:A method of increasing nucleic acid synthesis with ultrasound 发明人:UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID 权利人:IMARX PHARMACEUTICAL CORP 摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.
专利号:US-12231145-B1 优先权日:2022-02-24 标 题 :Systems and methods for digital signal synthesis with variable sample rate DAC 发明人:YU TOMMY; MADISETTI AVANINDRA 权利人:MIXED SIGNAL DEVICES INC 摘要:Systems and methods for digital signal synthesis with variable sample rate digital-to-analog converters (DACs) in accordance with various embodiments of the invention are described. One embodiment includes a digital frequency generator that includes a direct digital frequency synthesizer (DDFS); a digital-to-analog converter (DAC); a frequency/phase estimation circuit; a stable reference clock (REF CLK); a variable frequency sample clock; a frequency control word (FCW); where the DAC is sampled by the variable frequency sample clock; where the DDFS is clocked by the variable frequency sample clock; where the frequency/phase estimation circuit receives as inputs the stable REF CLK and the variable frequency sample clock and estimates a FCW frequency error and adjusts the FCW to the DDFS; where the DDFS receives the FCW and outputs a digital sine codeword at the variable frequency sample clock to the DAC, where the FCW to the DDFS is continuously adjusted to track the variable frequency sample clock.
专利号:US-10814013-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A2 优先权日:2006-10-05 标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
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