CAS: 69974-55-6; 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecadeuteriooctanoic Acid

主要参考文献

参考标题:Synthesis Of Deuterated [d32]Oleic Acid And Its Phospholipid Derivative [d64]Dioleoyl-Sn-Glycero-3-Phosphocholine
作者:Tamim A. Darwish,Emily Luks,Greta Moraes,Nageshwar R. Yepuri,Peter J. Holden,Michael James |发布日期:2013.7
摘要:Oleic Acid And Its Phospholipid Derivatives Are Fundamental To The Structure And Function Of Cellular Membranes. As A Result, There Has Been Increasing Interest In The Availability Of Their Deuterated Forms For Many Nuclear Magnetic Resonance, Infrared, Mass Spectroscopy And Neutron Scattering Studies. Here, We Present For The First Time A Straightforward, Large-Scale (Gram Quantities) Synthesis Of Highly Deuterated [d32]Oleic Acid By Using Multiple, Yet Simple And High Yielding Reactions. The Precursors For The Synthesis Of [d32]Oleic Acid Are [d14]Azelaic Acid And [d17]Nonanoic Acid, Which Were Obtained By Complete Deuteration (>98% D) Of Their 1H Forms By Using Metal Catalysed Hydrothermal H/d Exchange Reactions. The Oleic Acid Was Produced With Ca. 94% D Isotopic Purity And With No Contamination By The Trans-Isomer (Elaidic Acid). The Subsequent Synthesis Of [d64]Dioleoyl-Sn-Glycero-3-Phosphocholine From [d32]Oleic Acid Is Also Described. Copyright © 2013 John Wiley & Sons, Ltd.

合成参考文献

参考文献:10.1007/s00216-004-2992-4
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参考文献:10.1038/s41596-024-00980-6
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参考文献:10.1007/978-1-4939-7057-5_14
摘要:Christinat N, Morin-Rivron D, Masoodi M. High-Throughput Quantitative Lipidomics Analysis of Nonesterified Fatty Acids in Plasma by LC-MS. Methods Mol Biol. 2017;1619():183–91. doi: 10.1007/978-1-4939-7057-5_14.