CAS: 69974-55-6; 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecadeuteriooctanoic Acid

该化合物是一种饱和的脂肪酸,其特点是八碳链(C8),具有一个碳酸功能组. "d15"称该分子以98原子百分比的氢稳定同位素-浓缩,该分子的物理和化学特性与其非脱盐对应方相比有所改变.这种脱酸加强了其在各种应用中的用途,特别是在核磁共振光谱学中的用途,该物质因其独特的光谱特性而成为宝贵的内部标准或追踪器. 环氧-d15酸通常是在室温上无色液体,在有机溶剂中溶解. 它独特的同位素成分可以影响其再活动性和与生物系统的互动,从而在涉及脂代代代谢的代谢研究和研究中有所帮助. 此外,它可能被用于脱酸化合物合成,用于制药和化学研究,提供对反应机制和分子动态的见解.

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CAS号124-07-2 辛酸

合成工艺路线路线简述

    📜辛酸置于palladium On Activated Charcoal 氢气,重水体系中,110.0 °C,101.33 Kpa 条件下,反应 24.0H,以94%的收率获得产物辛酸-D15
    参考文献:借助pd / Ch(2)-D(2)o系统进行的烷基取代苯衍生物的高效h / D交换反应.
    标题:借助pd / Ch(2)-D(2)o系统进行的烷基取代苯衍生物的高效h / D交换反应.
    摘要:描述了一种有效和广泛的h / D取代苯衍生物的h / D交换的方法,该方法是在氢气氛下,在d(2)o中作为氘源的多相pd / C催化的.通过使用pd / Ch(2)-D(2)o系统将多氘掺入未活化的带有羧基,羟基,醚,酯或酰胺部分的直链或支链烷基链上,并与苯环连接.本方法不需要昂贵的氘气或任何专用设备.
    DOI:10.1002/chem.200601615

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    主要参考文献

    参考标题:Synthesis Of Deuterated [d32]Oleic Acid And Its Phospholipid Derivative [d64]Dioleoyl-Sn-Glycero-3-Phosphocholine
    作者:Tamim A. Darwish,Emily Luks,Greta Moraes,Nageshwar R. Yepuri,Peter J. Holden,Michael James |发布日期:2013.7
    摘要:Oleic Acid And Its Phospholipid Derivatives Are Fundamental To The Structure And Function Of Cellular Membranes. As A Result, There Has Been Increasing Interest In The Availability Of Their Deuterated Forms For Many Nuclear Magnetic Resonance, Infrared, Mass Spectroscopy And Neutron Scattering Studies. Here, We Present For The First Time A Straightforward, Large-Scale (Gram Quantities) Synthesis Of Highly Deuterated [d32]Oleic Acid By Using Multiple, Yet Simple And High Yielding Reactions. The Precursors For The Synthesis Of [d32]Oleic Acid Are [d14]Azelaic Acid And [d17]Nonanoic Acid, Which Were Obtained By Complete Deuteration (>98% D) Of Their 1H Forms By Using Metal Catalysed Hydrothermal H/d Exchange Reactions. The Oleic Acid Was Produced With Ca. 94% D Isotopic Purity And With No Contamination By The Trans-Isomer (Elaidic Acid). The Subsequent Synthesis Of [d64]Dioleoyl-Sn-Glycero-3-Phosphocholine From [d32]Oleic Acid Is Also Described. Copyright © 2013 John Wiley & Sons, Ltd.

    合成参考文献


    参考文献:10.1007/s00216-004-2992-4
    摘要:Siebert TE, Smyth HE, Capone DL, Neuwöhner C, Pardon KH, Skouroumounis GK, Herderich MJ, Sefton MA, Pollnitz AP. Stable isotope dilution analysis of wine fermentation products by HS-SPME-GC-MS. Analytical and Bioanalytical Chemistry. 2005 Jan 20;381(4):937–47. doi: 10.1007/s00216-004-2992-4.
    参考文献:10.1038/s41596-024-00980-6
    摘要:Han S, Guiberson ER, Li Y, Sonnenburg JL. High-throughput identification of gut microbiome-dependent metabolites. Nat Protoc. 2024 Jul;19(7):2180–205. doi: 10.1038/s41596-024-00980-6.
    参考文献:10.1007/978-1-4939-7057-5_14
    摘要:Christinat N, Morin-Rivron D, Masoodi M. High-Throughput Quantitative Lipidomics Analysis of Nonesterified Fatty Acids in Plasma by LC-MS. Methods Mol Biol. 2017;1619():183–91. doi: 10.1007/978-1-4939-7057-5_14.
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