CAS: 6966-01-4; Methyl 3-Amino-6-Bromopyrazine-2-Carboxylate

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486424-37-7 1196156-63-4 1260880-59-8

上下游产品

CAS号16298-03-6 3-氨基吡嗪-2-羧酸甲酯 | CAS号67-56-1 甲醇 | CAS号486424-37-7 3-氨基-6-溴吡嗪-2-甲酸 | CAS号5424-01-1 3-氨基吡嗪-2-羧酸 | CAS号486424-37-7 3-氨基-6-溴吡嗪-2-甲酸 | CAS号259794-06-4 6-溴-3-甲氧基吡嗪-2-羧酸甲酯 | CAS号957230-68-1 3,6-二溴吡嗪-2-甲酸 | CAS号1286238-55-8 3-氨基-6-[4-[[2-(... | CAS号13301-04-7 2,5-二溴-3-羧酸甲酯 | CAS号1232410-49-9 VE-821 | CAS号1256921-67-1 6-溴-3-氯吡嗪-2-甲酸甲酯

3-氨基吡嗪-2-羧酸甲酯置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙腈 作为反应溶剂,化学反应 24.0H,以87%的收率获得产物3-氨基-6-溴吡嗪-2-甲酸甲酯
参考文献:实用,循序渐进的法维拉韦治疗途径
标题:实用,循序渐进的法维拉韦治疗途径
摘要:开发了一种实用且循序渐进的途径开发抗病毒药物favipiravir.从三氨基吡嗪-2-羧酸仅用六步合成法维拉韦,总收率约为22.3%.通过从优化的溶剂中重结晶,可以得到纯度很高的关键中间体3和6,这有利于大规模生产.在关键的合成反应中,将3,6-二氯吡嗪-2-腈(6)在一个锅中依次与kf和30%H2O 2反应,得到(从95%etoh中结晶后)无色结晶的法维吡韦,合成的最后一步产率为60%.
DOI:10.1007/s11696-017-0208-6

专利信息

专利号:WO-2022009036-A1
优先权日:2020-07-06
标题:Synthesis of favipiravir
发明人：DESI REDDY SRINIVAS REDDY; VEDURURI MADHAVA REDDY
权利人:OPTIMUS DRUGS P LTD
摘要:The present invention relates to 6-Fluoro-3-hydroxypyrazine-2-carbonitrile ammonia salt and to an improved and commercially viable process for preparation of Favipiravir using 6-fluoro-3-hydroxypyrazine-2-carbonitrile ammonia salt.

专利号:US-9364482-B2
优先权日:2013-06-24
标 题 :Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
发明人：DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; NARGUND RAVI; XIAO DONG; ZORN NICOLAS; DANG QUN; MCCOMAS CASEY C; PENG XUANJIA; LI PENG; SOLL RICHARD
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. (I)

专利号:CN-117946013-B
优先权日:2024-01-25
标题:One-pot synthesis of 5,6-dihalogenated-3-aminopyrazine-2-carboxylic acid methyl ester

专利号:US-3249610-A
优先权日:1964-09-08
标 题 :Synthesis of 3-amino, 5-chloro, 6-substituted-pyrazinoates
发明人：GRAGOE JR EDWARD JETHRO; JONES JAMES H
权利人:MERCK & CO INC