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专利信息
专利号:US-7087743-B2
优先权日:2000-02-11
标 题 :Oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the synthesis of melanic pigments, as depigmentation agents
发明人:KURFURST ROBIN; JOLY REGINE
权利人:LVMH RECH
摘要:The present invention relates to novel oligonucleotide sequences and also to derivatives thereof. n These novel oligonucleotide sequences are capable of hybridizing specifically with the gene or with a product of the gene encoding tyrosinase, or with the gene or a product of the gene encoding tyrosinase-related-protein 1 (TRP-1). n The present invention also relates to the use of these novel oligonucleotide sequences as a depigmenting or bleaching agent in a cosmetic composition or in a dermatological composition.
专利号:EP-1600499-B1
优先权日:2003-03-03
标 题 :Process for producing lactonase and utilization thereof
发明人:SHIMIZU SAKAYU; KATAOKA MICHIHIKO; SAKAMOTO KEIJI
权利人:DAIICHI FINE CHEM CO LTD
摘要:It has been required to economically produce a large amount of optically active gamma -lactone derivatives (for example, pantolactone), which are useful as intermediates in synthesizing useful substances such as pharmaceutical drugs. To achieve this object, it is advantageous to employ an enzymatic technique of asymmetric hydrolysis with a hydrolyzing enzyme lactonase. However, it remains troublesome to prepare the enzyme or utilize a microorganism capable of producing the enzyme. Also, it is difficult to obtain a sufficient and stable enzymatic activity in the case of using recombination techniques. In producing lactonase, which asymmetrically hydrolyzes a gamma -lactone derivative such as racemic pantolactone selectively, by a recombination technique, both mature lactonase DNA and signal peptide region DNA are transferred into a host. Thus, a stable lactonase activity comparable to naturally-occurring one can be achieved and a transformant sustaining a high enzyme activity in a stable manner can be acquired, thereby allowing the efficient and industrially advantageous asymmetric synthesis of gamma -lactone derivatives.
专利号:CN-101067135-A
优先权日:2000-02-11
标题 :Novel oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the synthesis of melanic pigments, as depigmentation agents
专利号:JP-2008043334-A
优先权日:2000-02-11
标 题:New oligonucleotide and use of oligonucleotide modulating expression of enzyme involved in synthesis of melanic pigment, as decolorant
专利号:EP-1255827-B1
优先权日:2000-02-11
标 题 :Oligonucleotides and their use for modulating the expression of tyrosinase involved in the synthesis of melanic pigments
专利号:KR-20030004349-A
优先权日:2000-02-11
标 题 :Novel oligonucleotides and uses of oligonucleotides which modulate the expression of enzymes involved in the synthesis of melanin pigments, as depigmenting agents