CAS: 64065-08-3; Dimethylphosphanylmethyl(Dimethyl)Phosphane

上下游产品

2PMe2LiCH2PMe2 chlorodimethylphosphine dichloromethane tetramethyldiphosphanebis(p-methoxy-phenyl-imino-dimethylphosphoranyl)methane bis(p-nitro-phenyl-imino-dimethylphosphoranyl)methane acetonitrile bis(dimethylphosphino)methyl anion

📜双(二氯磷氢基)甲烷 以77%的收率获得产物
参考文献:Prishchenko A. A.; Nifantev Eh. N.; Novikova Z. S.; Lutsenko I. F.,Zh. Obshch. Ximii,1980,50,Ho 8,1881-1882
标题:Prishchenko A. A.; Nifantev Eh. N.; Novikova Z. S.; Lutsenko I. F.,Zh. Obshch. Ximii,1980,50,Ho 8,1881-1882

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-11447454-B2
优先权日:2015-08-07
标题:Synthesis of benzodiazepine derivatives
发明人：BOYCE MALCOLM JAMES; THOMSEN LIV; GILBERT DONALD ALAN; WOOD DAVID
权利人:TRIO MEDICINES LTD
摘要:The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I:

专利号:US-11738092-B2
优先权日:2019-12-04
标题:Methods and compositions for synthesis of therapeutic nanoparticles
发明人：WYENT EMILY A; BLUMENFELD CARL M; LAMM ROBERT J
权利人:DANTARI INC
摘要:Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.

专利号:US-2023119227-A1
优先权日:2020-02-24
标 题:Oligonucleotide synthesis on solid support
发明人：JI AN; MARVIN MICHAEL; MARKS KEVIN; ANDERSON DAVID
权利人:INTEGRATED DNA TECH INC
摘要:Functionalized solid supports are useful in the synthesis of oligonucleotides. The functionalized solid supports contain an extended linker to a terminal functional group or a first nucleotide or nucleoside moiety. The extended linker permits oligonucleotide synthesis to take place at a greater distance from the solid support with greater efficiency.

专利号:US-2023357286-A1
优先权日:2020-07-24
标 题:Ketone synthesis and applications
发明人：KISHI YOSHITO; UMEHARA ATSUSHI
权利人:HARVARD COLLEGE
摘要:Provided are new nickel./zirconium-mediated coupling reactions useful in the synthesis of ketone-containing compounds, e.g., halichondrin natural products and related molecules. A feature of the present disclosure is the use of a nickel(I) catalyst in tandem with a nickel (II) catalyst in the Ni/Zr-mediated coupling reactions. Without wishing to be bound by any particular theory, the nickel (I) catalyst selectively activates the electrophilic coupling partner (i.e., the compound of Formula (A)), and the nickel(ll) catalyst selectively activates the nucleophilic coupling partner (i.e., a thioester of Formula (B)). This dual catalyst system leads to improved coupling efficiency and eliminates the need for a large excess of one of the coupling partners (i.e., a compound of Formula (A) or (B)).

专利号:WO-2024168123-A1
优先权日:2023-02-09
标 题 :Synthesis of core 2 o-sialyl lewis-x polysaccharides
发明人：CHAIKOF ELLIOT; DHAKAL BIBEK; MANDHAPATI APPI; ERADI PRADHEEP
权利人:BETH ISRAEL DEACONESS MEDICAL CT INC
摘要:Provided herein are methods and compounds useful in the preparation of Core 2 O -sialyl Lewis x polysaccharides including compounds of Formula (C).