2,6-二硝基苯酚置于3-氯-2-甲基-5-苯基异恶唑氯化物,三乙胺体系中,用 Xylene 作为反应溶剂,化学反应生成 2,6-二硝基氯苯 参考文献:Tomita,K. Et Al.,Chemical And Pharmaceutical Bulletin,1979,Vol. 27,P. 2415-2423 标题:Tomita,K. Et Al.,Chemical And Pharmaceutical Bulletin,1979,Vol. 27,P. 2415-2423
专利号:US-8729303-B2 优先权日:2006-08-10 标 题:2,2′,6,6′-tetrasubstituted aminophosphine ligand and its synthesis method 发明人:ZHANG WANBIN; XIE FANG; FANG FANG 权利人:ZHANG WANBIN; XIE FANG; FANG FANG; UNIV SHANGHAI JIAOTONG 摘要:The present invention relates to a 2,2′,6,6′-tetrasubstituted aminophosphine ligand and its synthesis method. The structure of the ligand is shown as below. Its synthesis method comprises: Step (1) coupling 2,6-dinitrochlorobenzene as the starting material to obtain 2,2′,6,6′-tetranitrobiphenyl; Step (2): hydrogenating the 2,2′,6,6′-tetranitrobiphenyl with Pd/C to obtain 2,2′,6,6′-tetraminobiphenyl; Step (3): reacting the 2,2′,6,6′-tetraminobiphenyl with a phosphine halide to obtain the 2,2′,6,6′-tetrasubstituted aminophosphine ligand. The ligand of the present invention is an achiral compound, and its preparation method is simple. The ligand can be converted to a chiral bimetallic catalyst with single configuration eventually through introduction of external chirality. Moreover, the ligand can be used in various asymmetric reaction catalyzed by metals with high reactivity and stereoselectivity.
专利号:US-4797427-A 优先权日:1987-04-25 标题:Aromatic diamines containing sulfonic acid aryl esters, a process for their production and their use in the production of polyurethane plastics 发明人:SANDERS JOSEF; REIFF HELMUT; BALLE GERHARD; DIETERICH DIETER 权利人:BAYER AG 摘要:The present invention is directed to new aromatic diamines containing sulfonic acid aryl esters corresponding to the formula wherein R1 represents hydrogen, an optionally branched C1-C6 alkyl radical (preferably a methyl group), a C1-C6 alkoxy radical or a halogen atom (preferably chlorine) and R2 and R3 which may be the same or different, represent hydrogen, an optionally branched C1-C20 (preferably C1-C6) alkyl radical, a C1-C6 alkoxy radical or a halogen atom (preferably chlorine). The present invention is also directed to a process for the production of the above aromatic diamines containing sulfonic acid esters by the reaction of optionally substituted sulfochlorides with optionally substituted phenols followed by hydrogenation. Finally, the present invention is directed to the use of aromatic diamines containing sulfonic acid aryl esters as a synthesis component for the production of polyurethane plastics by the isocyanate polyaddition process.
专利号:CN-110156712-A 优先权日:2019-04-25 标 题 :A kind of synthesis of benzoxazole compounds and its application by utilizing aromatic hydrocarbon nitration by-products
专利号:CN-119798082-A 优先权日:2024-12-27 标题 :Synthesis method of o-chloronitrobenzene
摘要:American Medical Association, AMA Department of Drugs. AMA Drug Evaluations. 4th ed. Chicago: American Medical Association, 1980., p. 1132 摘要:Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 1027 摘要:Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V1 719