合成目标产物 (S)-(+)-2-(Dibenzylamino)-1-Propanol 主要起始原料 L-Alaninol And Benzyl Bromide
(文献来源)合成步骤主要原料 L-Alaninol 和 Benzyl Bromide
📜溴甲苯置于lithium Aluminium Tetrahydride,Potassium Carbonate,Sodium Hydroxide体系中,用 乙醚,水 作为反应溶剂,化学反应生成 (S)-(+)-2-(二苄氨基)-1-丙醇 参考文献:Khmds/triglyme Cryptate As An Alternative To Phosphazene Base In Stereodivergent Pentafluoroethylation Of N-Sulfinylimines Using Hfc-125 标题:Khmds/triglyme Cryptate As An Alternative To Phosphazene Base In Stereodivergent Pentafluoroethylation Of N-Sulfinylimines Using Hfc-125 摘要: DOI:10.1021/acs.Joc.2C01821
专利号:US-9446995-B2 优先权日:2012-05-21 标 题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions 发明人:CHONG HYUN-SOON 权利人:CHONG HYUN-SOON; ILLINOIS INST OF TECH 摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.
专利号:US-2017008863-A1 优先权日:2008-02-22 标 题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
参考标题:Synthetic And Theoretical Investigation On The One-Pot Halogenation Of β-Amino Alcohols And Nucleophilic Ring Opening Of Aziridinium Ions 作者:Yunwei Chen,Xiang Sun,Ningjie Wu,Jingbai Li,Shengnan Jin,Yongliang Zhong,Zirui Liu,Andrey Rogachev,Hyun-Soon Chong 摘要:Aziridinium Ions Are Useful Reactive Intermediates For The Synthesis Of Enantiomerically Enriched Building Blocks. However, N,N-Dialkyl Aziridinium Ions Are Relatively Underutilized In The Synthesis Of Optically Active Molecules As Compared To Other Three-Membered Ring Cogeners, Aziridines And Epoxides. The Characterization Of Both Optically Active Aziridinium Ions And Secondary β-Halo Amines As The