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参考文献:Kharasch; Kleiger; Mayo,Journal Of Organic Chemistry,1939,Vol. 4,P. 431,434
标题:Kharasch; Kleiger; Mayo,Journal Of Organic Chemistry,1939,Vol. 4,P. 431,434
专利信息
专利号:WO-2019016826-A1
优先权日:2017-07-17
标 题:NOVEL 5- [4- (2-BIPHENYL-4-YL-2-OXOETHOXY) BENZYLIDENE] THIAZOLIDINE-2,4-DIONES, THEIR SYNTHESIS AND USES THEREOF
发明人:THAREJA SURESH; VERMA SANT KUMAR; JAIN AKHLESH KUMAR; BHARDWAJ TILAK RAJ
权利人:GURU GHASIDAS VISHWAVIDYALAYA A CENTRAL UNIV; INDIAN COUNCIL OF MEDICAL RES ICMR
摘要:Disclosed are novel 5-[4-(2-biphenyl-4-yl-2-oxo-ethoxy)-benzylidene]-thiazolidine-2,4-dione compounds of general formula (I), their pharmaceutically acceptable salts, solvates their synthesis and uses thereof, to pharmaceutical compositions containing compounds and to the use of such compounds and composition in medicines either alone or in combination with other compounds.
专利号:WO-2011029896-A1
优先权日:2009-09-11
标 题 :Methods of preparation of muscarinic acetylcholine receptor antagonists
发明人:CARANGIO ANTONELLA; CHEUNG IZABEL; D SOUZA ERIN CARMEN FRANCES; LEAHY JOHN HENRY; STRACHAN JOHN BRYCE
权利人:GLAXO GROUP LTD; CARANGIO ANTONELLA; CHEUNG IZABEL; D SOUZA ERIN CARMEN FRANCES; LEAHY JOHN HENRY; STRACHAN JOHN BRYCE
摘要:The present application describes novel intermediates useful in the synthesis of mAChRs and methods for preparing these intermediates, comprising a compound of Formula (II): wherein, P is a suitably nitrogen protecting group; R is selected from the group consisting of C 1 - 8 alkyl, C 2 - 8 alkenyl, C 2 - 8 alkynyl, C 3 - 6 cycloalkyl, C 3 - 6 cycloalkenyl, heterocyclic, heterocyclic C 1 - 4 alkyl, aryl, aryl C 1 - 4 alkyl and heteroaryl C 1 - 4 alkyl; and Y is a suitable leaving group.
专利号:US-4150032-A
优先权日:1978-01-18
标 题 :9-Oxobenzomorphan process and intermediates
发明人:KAVADIAS GERRY
权利人:BRISTOL MYERS CO
摘要:Improved processes for preparing 2'-alkoxy-2,5-di-substituted-9-oxo-6,7-benzomorphans from benz[e]indolines and synthesis of the benz[e]indoline intermediates are described. A representative example involves synthesis of 9b-allyl-8-methoxy-3-methyl-5,9b-dihydrobenz[e]indoline and bromination thereof to 9b-allyl-4-bromo-8-methoxy-2,4,5,9b-tetrahydro-1H-benz[e]indole methylbromide which is then hydrolyzed with a weak base such as ammonium bicarbonate to provide 5-allyl-2'-methoxy-2-methyl-9-oxo-6,7-benzomorphan.
专利号:US-4234731-A
优先权日:1979-01-05
标题:9-Oxobenzomorphan process
发明人:KAVADIAS GERRY
权利人:BRISTOL MYERS CO
摘要:Improved processes for preparing 2'-alkoxy-2,5-di-substituted-9-oxo-6,7-benzomorphans from benz[e]indolines and synthesis of the benz[e]indoline intermediates are described. A representative example involves synthesis of 9b-allyl-8-methoxy-3-methyl-5,9b-dihydrobenz[e]indoline and bromination thereof to 9b-allyl-4-bromo-8-methoxy-2,4,5,9b-tetrahydro-1H-benz[e]indole methylbromide which is then hydrolyzed with a weak base such as ammonium bicarbonate to provide 5-allyl-2'-methoxy-2-methyl-9-oxo-6,7-benzomorphan.
专利号:US-6011133-A
优先权日:1993-03-05
标 题:Laminates of glass or metal and poly(alkylene dicarboxylates) and syntheses thereof
发明人:PINKUS ALVIN G; HARIHARAN RAJAN
权利人:UNIV BAYLOR
摘要:Poly(alkylene dicarboxylate) polymers and copolymers having tetraalkyl- or trialkylammonium ion end groups and methods of synthesis, thereof. The methylene-containing copolymers, in general, adhere to glass and metals, including aluminum, iron, and copper. Poly(methylene-co-ethylene terephthalate) is a clear film useful in the protection of metals or glass from corrosion or scratching. Glass may be bound to glass or to metal using the polymers of the present invention or metal to metal seals may be made.
专利号:US-9018325-B2
优先权日:2011-08-25
标题 :Catalyst for living radical polymerization and polymerization method
发明人:GOTO ATSUSHI; KAJI HIRONORI
权利人:GOTO ATSUSHI; KAJI HIRONORI; UNIV KYOTO
摘要:A nonmetallic compound having an ionic bond with a halide ion is used as a catalyst for living radical polymerization. Even if a radical initiator is not used, a monomer can be subjected to a radical polymerization to obtain a polymer having narrow molecular weight distribution. The cost of the living radical polymerization can be remarkably reduced, and it is made possible to prevent adverse effects of using a radical initiator (such as side reactions). The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages such as low toxicity of the catalyst, low amount of the catalyst necessary, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor, etc. The catalyst can be applied to various monomers and enables synthesis of high molecular weight polymers.