专利号:WO-2018191771-A1 优先权日:2017-04-18 标题 :Detection and treatment of congenital malformations 发明人:DUNWOODIE SALLY; SPARROW DUNCAN; STOCKER ROLAND; SHI HONGJUN 权利人:VICTOR CHANG CARDIAC RES INSTITUTE 摘要:The invention relates to a method of preventing or treating a congenital malformation in an unborn offspring of a subject, the method comprising administering to the subject a therapeutically effective amount of NAD or an intermediate of NAD synthesis.
专利号:US-2024216412-A1 优先权日:2022-11-22 标 题 :Oxidized nicotinamide adenine dinucleotide (nad+) precursor treatment for heart failure alleviation independent of mitochondrial protein deacetylation 发明人:TIAN RONG; WALKER MATTHEW 权利人:UNIV WASHINGTON 摘要:The current disclosure provides provides boosting intracellular NAD + with nicotinamide riboside chloride (NR) to protect from cardiac dysfunction, NR being a natural NAD + precursor that bypasses nicotinamide phosphoribosyltransferase (NAMPT) to stimulate intracellular NAD + synthesis.
专利号:CA-2318412-A1 优先权日:1999-01-22 标题:Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate
专利号:US-8790720-B2 优先权日:2011-12-22 标题:Compositions and methods for treating skin 发明人:RICHARDS JEANETTE ANTHEA; DAWSON THOMAS LARRY; COMBS MARY JANE; DUEVA-KOGANOV OLGA; KOGANOV MICHAEL 权利人:PROCTER & GAMBLE 摘要:The present invention relates to skin care compositions comprising blends of camellia and feverfew serum fractions and/or kelp and parsley serum fractions. The skin care compositions also comprise a dermatologically acceptable carrier. The invention also relates to methods for increasing melanin production in skin by topically applying the skin care composition to areas in order to stimulate one or more steps in melanin synthesis and/or interrupt an inflammatory cycle.
参考文献:10.1007/978-1-4899-7130-2_7 摘要:Albert A. Structure-activity relationships. The nature of chemical bonds. Adsorption. The influence of seemingly inert groups on biological action. 1973. In: Selective Toxicity. 参考文献:10.1007/bf00374841 摘要:Ullrich KJ, Rumrich G. Renal contraluminal transport systems for organic anions (paraaminohippurate, PAH) and organic cations (N1 methyl-nicotinamide, NMeN) do not see the degree of substrate ionization. Pflügers Archiv - European Journal of Physiology. 1992 Jun;421(2-3):286–8. doi: 10.1007/bf00374841.