CAS: 58539-65-4; 2-Methylnicotinamide

该化合物是一个有机化合物,其特征为:环结构,由六人组成,含有一个氮原子的芳香环.该化合物的特征为:附于环的碳旦胺功能组(-C(=O)NH2),具体为3位置,和2位置的甲基组(-CH3),通常是白色到白色以外的固体,在水和酒精等极地溶剂中溶解.该化合物可能展示生物活动,引起药物研究的兴趣.其熔点,沸点和特定再活性可能因环境条件和纯度而不同.与许多含氮的外生循环一样,它可能参与各种化学反应,包括核生殖替代和凝聚反应,使它成为有机合成的多用途建筑构件.应当查阅关于处理和储存所有化学物质的热剂的数据.

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1721-23-9 58539-66-5 58539-64-3

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上下游产品

ethyl 2-methyl nicotinate methyl 2-methylnicotinate pyridine 2-methylnicotinic acid imidazolide 2-methyl-3-pyridinamine 1-benzyl-2-methyl-3-carbamoylpyridinium bromide 2-methyl-nicotinonitrile 1,6-naphthyridine-5(6H)-one

合成工艺路线路线简述

    📜2-甲基烟酸乙酯置于氨体系中,化学反应生成 2-甲基烟酰胺
    参考文献:49. 4-和5-氮杂吲哚衍生物的合成
    标题:49. 4-和5-氮杂吲哚衍生物的合成
    摘要:
    DOI:10.1039/jr9480000198

    海关参考信息

    专利信息


    专利号:WO-2018191771-A1
    优先权日:2017-04-18
    标题 :Detection and treatment of congenital malformations
    发明人:DUNWOODIE SALLY; SPARROW DUNCAN; STOCKER ROLAND; SHI HONGJUN
    权利人:VICTOR CHANG CARDIAC RES INSTITUTE
    摘要:The invention relates to a method of preventing or treating a congenital malformation in an unborn offspring of a subject, the method comprising administering to the subject a therapeutically effective amount of NAD or an intermediate of NAD synthesis.

    专利号:US-2024216412-A1
    优先权日:2022-11-22
    标 题 :Oxidized nicotinamide adenine dinucleotide (nad+) precursor treatment for heart failure alleviation independent of mitochondrial protein deacetylation
    发明人:TIAN RONG; WALKER MATTHEW
    权利人:UNIV WASHINGTON
    摘要:The current disclosure provides provides boosting intracellular NAD + with nicotinamide riboside chloride (NR) to protect from cardiac dysfunction, NR being a natural NAD + precursor that bypasses nicotinamide phosphoribosyltransferase (NAMPT) to stimulate intracellular NAD + synthesis.

    专利号:CA-2318412-A1
    优先权日:1999-01-22
    标题:Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate

    专利号:US-8361516-B2
    优先权日:2006-08-03
    标 题:Composition comprising sarsasapogenin
    发明人:LINTNER KARL; MAS CHAMBERLIN CLAIRE
    权利人:SEDERMA SA; LINTNER KARL; MAS CHAMBERLIN CLAIRE
    摘要:The présent invention relates to a composition comprising sarsasapogenin or a plant extract containing it in order to improve the gêneral state of the skin and in particular to improve and/or embellish any part of the body showing a déficit in lipids. More particularly, the invention is directed to a cosmetic method to improve the figure, comprising the step of topically applying to the skin a cosmetic or dermopharmaceutical composition comprising sarsasapogenin to favour the expansion and/or the formation of the subcutaneous adipose tissue, and/or to favour the lipid synthesis in the epidermis.

    专利号:US-8790720-B2
    优先权日:2011-12-22
    标题:Compositions and methods for treating skin
    发明人:RICHARDS JEANETTE ANTHEA; DAWSON THOMAS LARRY; COMBS MARY JANE; DUEVA-KOGANOV OLGA; KOGANOV MICHAEL
    权利人:PROCTER & GAMBLE
    摘要:The present invention relates to skin care compositions comprising blends of camellia and feverfew serum fractions and/or kelp and parsley serum fractions. The skin care compositions also comprise a dermatologically acceptable carrier. The invention also relates to methods for increasing melanin production in skin by topically applying the skin care composition to areas in order to stimulate one or more steps in melanin synthesis and/or interrupt an inflammatory cycle.

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    合成参考文献


    参考文献:10.1007/978-1-4899-7130-2_7
    摘要:Albert A. Structure-activity relationships. The nature of chemical bonds. Adsorption. The influence of seemingly inert groups on biological action. 1973. In: Selective Toxicity.
    参考文献:10.1007/bf00374841
    摘要:Ullrich KJ, Rumrich G. Renal contraluminal transport systems for organic anions (paraaminohippurate, PAH) and organic cations (N1 methyl-nicotinamide, NMeN) do not see the degree of substrate ionization. Pflügers Archiv - European Journal of Physiology. 1992 Jun;421(2-3):286–8. doi: 10.1007/bf00374841.
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