CAS: 57-57-8; Propiolactone

该化合物是一种高度反应性的循环酯(C3H4O2),在制药和生物技术应用中广泛用作消毒剂和烷基剂(C3H4O2),其主要优点包括具有很强的病毒和细菌杀菌特性,能够有效地在疫苗和生物产品中活化病原体.BPL水解液解液解冻迅速,最大限度地减少残留毒性,其小分子体积能确保彻底渗透.它也被用作有机合成的中间体,特别是丙烯衍生物.由于它的再活性,处理需要严格的安全措施.BPL的效率和可降解性使它在敏感应用中成为受控制的绝育过程的首选.

结构式图片

相似化合物

3068-88-0 1823-54-7 1955-45-9

欧盟法规

统一分类与标签压力设备指令-第1组危险流体REACH注册ECHA物质ECHA物质食品接触材料-禁用CMR物质化妆品禁用物质清单工作场所安全标识要求C&L通报REACH预注册废弃物危险特性清单

上下游产品

CAS号75-21-8 环氧乙烷 | CAS号201230-82-2 carbon monoxide | CAS号5009-27-8 环丙烷酮 | CAS号590-92-1 3-溴丙酸 | CAS号504-63-2 1,3-丙二醇 | CAS号463-51-4 乙烯酮 | CAS号50-00-0 甲醛 | CAS号107-95-9 β-丙氨酸 | CAS号56-86-0 L-谷氨酸 | CAS号78-40-0 磷酸三乙酯 | CAS号110766-84-2 8-chloro-3,5-di... | CAS号110766-85-3 8-bromo-3,5-dih... | CAS号3699-67-0 3-膦酰丙酸三乙脂 | CAS号108845-16-5 3-(3-diethoxyph... | CAS号4767-00-4 3-(2-苯并噻唑基硫代)丙酸 | CAS号503-66-2 3-羟基丙酸 | CAS号3395-91-3 3-溴丙酸甲酯 | CAS号3284-79-5 3-(4-氯苯氧基)丙酸 | CAS号4771-80-6 3-环己烯-1-甲酸 | CAS号5724-76-5 3-(2,5二氧-吡咯啉-1-基)-丙酸

合成工艺路线路线简述

    📜环丙烷酮置于nickel(II) Iodide,Dowex 50W,铁粉 氧气,苯甲醛体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 15.0H,以94%的收率获得产物β-丙内酯
    参考文献:Hashemi; Beni,Journal Of Chemical Research-Part S,2000,# 4,P. 196-197
    标题:Hashemi; Beni,Journal Of Chemical Research-Part S,2000,# 4,P. 196-197

    海关参考信息

    专利信息


    专利号:WO-2015198349-A1
    优先权日:2014-06-25
    标 题 :A one pot synthesis of 3-substituted quinoline carboxylates and its derivatives
    发明人:GADAKH SUNITA KHANDERAO; SUDALAI ARUMUGAM
    权利人:COUNCIL SCIENT IND RES
    摘要:The present invention provides a one pot, simple, cost effective and industrially feasible catalytic synthesis of quinolines or substituted quinolines from anilines with yield >80% yield. The present invention also discloses a process for the synthesis of oxolinic acid using quinolines with yield > 45%.

    专利号:US-7358382-B2
    优先权日:2001-08-03
    标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production
    发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
    权利人:BAYER SCHERING PHARMA AG
    摘要:The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.

    专利号:US-7368568-B2
    优先权日:2001-08-03
    标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use
    发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
    权利人:BAYER SCHERING PHARMA AG
    摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroarnides for the synthesis of edothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

    专利号:US-6417380-B1
    优先权日:1987-12-31
    标 题 :Synthesis of 1,2-dioxetanes and intermediates therefor
    发明人:BRONSTEIN IRENA Y; EDWARDS BROOKS
    摘要:Compounds having the formula: n wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C 1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., n m-phenylene), produced by reacting a compound having the formula: n with an R-ylating agent (e.g., R 2 SO 4 ) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: n are produced by reacting a compound having the formula: n with n wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula n are produced by reacting a compound of the formula n with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups. The aforementioned compounds and procedures are useful in the synthesis of enzyme-cleavable 1,2-dioxetane ring systems that can serve as members of a binding pair employed, for example, in chemiluminescent immunoassays, DNA probe assays, and direct assays for an enzyme.

    专利号:US-6417290-B1
    优先权日:2001-01-29
    标题:Synthesis of energetic polyester thermoplastic homopolymers and energetic thermoplastic elastomers formed therefrom
    发明人:AMPLEMAN GUY; BROCHU SYLVIE
    权利人:DEPT OF NAT DEFENCE
    摘要:Polymerization of α-bromomethyl-α-methyl-β-propiolactone (BMMPL) or α-chloromethyl-α-methyl-β-propiolactone (CMMPL) yielded thermoplastic homopolymers that upon azidation led to a novel energetic thermoplastic polyester: poly(α-azidomethyl-α-methyl-β-propiolactone) (PAMMPL). An energetic copolyether-ester thermoplastic elastomer was prepared by using glycidyl azide polymer, a dihydroxyl terminated energetic polymer, as a macroinitiator for the polymerization of BMMPL or CMMPL. The azidation of the resulting copolyether-ester yielded an energetic thermoplastic elastomer that melted at between 80° C. and 85° C. Polymerization of α-dibromomethyl-β-propiolactone (DBMPL) resulted in a polymer which upon azidation yielded a new energetic polymer that can be used as a binder or into an energetic thermoplastic elastomer synthesis.

    专利号:US-6933385-B2
    优先权日:2001-08-03
    标题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
    发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
    权利人:SCHERING AG
    摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Cinzia Zanotti, Et Al. A Simple Method For Measuring Porcine Circovirus 2 Whole Virion Particles And Standardizing Vaccine Formulation. Biologicals. 2015 Mar;43(2):79-83.
    [参考文献]: Cristina Avonto, Et Al. A Fluorescence High Throughput Screening Method For The Detection Of Reactive Electrophiles As Potential Skin Sensitizers. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):177-84.
    [参考文献]: Frantiek Surman, Et Al. Polymer Brushes Interfacing Blood As A Route Toward High Performance Blood Contacting Devices. Macromol Biosci. 2015 May;15(5):636-46.
    [参考文献]: Li Sheng-Fowler, Et Al. Quantitative Determination Of The Infectivity Of The Proviral Dna Of A Retrovirus In Vitro: Evaluation Of Methods For Dna Inactivation. Biologicals. 2009 Aug;37(4):259-69.
    [参考文献]: M H Koldijk, Et Al. A Sensitive Cell-Based Assay For The Detection Of Residual Infectious West Nile Virus. Vaccine. 2007 Sep 28;25(39-40):6872-81.

    合成参考文献


    摘要:Croft, R. A.; Bull, J. A., Science of Synthesis Knowledge Updates, (2018) 4, 423.
    摘要:American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 497
    摘要:Woodworth BA et al; Cancer Lett 31 (3): 293-97 (1986)
    摘要:Montesano, R., H. Bartsch, E.Boyland, G. Della Porta, L. Fishbein, R. A. Griesemer, A.B. Swan, L. Tomatis, and W. Davis (eds.). Handling Chemical Carcinogens in the Laboratory: Problems of Safety. IARC Scientific Publications No. 33. Lyon, France: International Agency for Research on Cancer, 1979., p. 17
    摘要:
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