专利号:WO-2015198349-A1 优先权日:2014-06-25 标 题 :A one pot synthesis of 3-substituted quinoline carboxylates and its derivatives 发明人:GADAKH SUNITA KHANDERAO; SUDALAI ARUMUGAM 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a one pot, simple, cost effective and industrially feasible catalytic synthesis of quinolines or substituted quinolines from anilines with yield >80% yield. The present invention also discloses a process for the synthesis of oxolinic acid using quinolines with yield > 45%.
专利号:US-7358382-B2 优先权日:2001-08-03 标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production 发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN 权利人:BAYER SCHERING PHARMA AG 摘要:The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.
专利号:US-7368568-B2 优先权日:2001-08-03 标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use 发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN 权利人:BAYER SCHERING PHARMA AG 摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroarnides for the synthesis of edothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.
专利号:US-6417380-B1 优先权日:1987-12-31 标 题 :Synthesis of 1,2-dioxetanes and intermediates therefor 发明人:BRONSTEIN IRENA Y; EDWARDS BROOKS 摘要:Compounds having the formula: n wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C 1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., n m-phenylene), produced by reacting a compound having the formula: n with an R-ylating agent (e.g., R 2 SO 4 ) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: n are produced by reacting a compound having the formula: n with n wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula n are produced by reacting a compound of the formula n with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups. The aforementioned compounds and procedures are useful in the synthesis of enzyme-cleavable 1,2-dioxetane ring systems that can serve as members of a binding pair employed, for example, in chemiluminescent immunoassays, DNA probe assays, and direct assays for an enzyme.
专利号:US-6417290-B1 优先权日:2001-01-29 标题:Synthesis of energetic polyester thermoplastic homopolymers and energetic thermoplastic elastomers formed therefrom 发明人:AMPLEMAN GUY; BROCHU SYLVIE 权利人:DEPT OF NAT DEFENCE 摘要:Polymerization of α-bromomethyl-α-methyl-β-propiolactone (BMMPL) or α-chloromethyl-α-methyl-β-propiolactone (CMMPL) yielded thermoplastic homopolymers that upon azidation led to a novel energetic thermoplastic polyester: poly(α-azidomethyl-α-methyl-β-propiolactone) (PAMMPL). An energetic copolyether-ester thermoplastic elastomer was prepared by using glycidyl azide polymer, a dihydroxyl terminated energetic polymer, as a macroinitiator for the polymerization of BMMPL or CMMPL. The azidation of the resulting copolyether-ester yielded an energetic thermoplastic elastomer that melted at between 80° C. and 85° C. Polymerization of α-dibromomethyl-β-propiolactone (DBMPL) resulted in a polymer which upon azidation yielded a new energetic polymer that can be used as a binder or into an energetic thermoplastic elastomer synthesis.
专利号:US-6933385-B2 优先权日:2001-08-03 标题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use 发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN 权利人:SCHERING AG 摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.
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合成参考文献
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