CAS: 52-51-7; Bronopol

相似化合物

1794-90-7 69094-18-4 5447-97-2

上下游产品

formaldehyd bromonitromethane 2-hydroxymethyl-2-nitro-propane-1,3-diol nitromethane N-p-tolyl-benzimidoyl)-disulfanebis-(N-p-tolyl-benzimidoyl)-disulfane N-[1]naphthyl-benzimidoyl)-disulfanebis-(N-[1]naphthyl-benzimidoyl)-disulfane 2-bromo-2-nitro-1-ethanol bromopicrin

1,3-Dichloro-2-Nitropropane置于水,五溴化磷体系中,用 乙醇 作为反应溶剂,化学反应 48.0H,以85%的收率获得产物2-溴-2-硝基-1,3-丙二醇
参考文献:一种溴硝醇的制备方法
标题:一种溴硝醇的制备方法
摘要:本发明公开了一种溴硝醇的制备方法,其特征在于,包括如下制备步骤:将化合物1A与硝化试剂进行反应,得到化合物2A;将上述的化合物2A与水进行水解反应,再与溴化试剂进行反应,即得溴硝醇粗品,经过纯化后,得到溴硝醇精品.本发明采用价格较低的试剂作为起始原料,经过硝化,水解,溴化等反应,得到最终产品,每步的反应条件温和,得到的溴硝醇收率高,能够大幅降低成本.

专利信息

专利号:US-12221452-B2
优先权日:2017-10-04
标题:Synthesis of cantharidin
发明人：DAVIDSON MATTHEW GENE; EKLOV BRIAN MATTHEW; WUTS PETER; LOERTSCHER BRAD MELVIN; SCHOW STEVEN R
权利人:VERRICA PHARMACEUTICALS INC
摘要:The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions (e.g., infectious diseases and skin conditions).

专利号:US-11155562-B2
优先权日:2014-06-30
标 题 :Synthesis of halichondrin analogs and uses thereof
发明人：KISHI YOSHITO; UEDA ATSUSHI; YAMAMOTO AKIHIKO; KATO DAISUKE
权利人:HARVARD COLLEGE
摘要:The present invention provides halichondrin analogs, such as compounds of Formula (I). The compounds may bind to microtubule sites, thereby inhibiting microtubule dynamics. Also provided are methods of synthesis, pharmaceutical compositions, kits, methods of treatment, and uses that involve the compounds for treatment of a proliferative disease (e.g., cancer). Compounds of the present invention are particularly useful for the treatment of metastatic breast cancer, non-small cell lung cancer, prostate cancer, and sarcoma. The included methods of synthesis are useful for the preparation of compounds of Formula (I)-(III) along with naturally occurring halicondrins (e.g., halichondrin B & C, norhalichondrin A, B, & C, and homohalichondrin A, B, & C). Also included are methods for interconverting between the halichondrins, norhalichondrins, and homohalichondrins and their unnatural epimers at the C38 ketal stereocenter through the use of an acid-mediated equilibration.

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-2014378538-A1
优先权日:2011-12-14
标 题:Methods of responding to a biothreat
发明人：BANCEL STEPHANE
权利人:MODERMA THERAPEUTICS INC
摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.

专利号:US-2024309142-A1
优先权日:2023-03-17
标题 :Capped block copolymers, their synthesis, manufacture, and methods of use
发明人：MAN VICTOR FUK-PONG; LI XIAOJIN HARRY; CHEN YIQING; PU GANG; HUNT JR CLINTON
权利人:ECOLAB USA INC
摘要:This disclosure relates to capped block copolymers, preferably reverse block copolymers capped with a hydrophobic group. Preferred hydrophobic groups include benzyl groups and silyl groups. In a preferred embodiment, the reverse block copolymer has at least two arms, wherein each arm is capped with a hydrophobic group. The disclosure also provides for the synthesis of the capped block copolymers as well as methods of using the capped block copolymers for defoaming and antifoaming applications.

专利号:US-2024376504-A1
优先权日:2021-04-08
标题 :Enzymatic synthesis of mycosporine-like amino acids
发明人：DING YOUSONG; CHEN MANYUN
权利人:UNIV FLORIDA
摘要:The present invention relates to methods of producing compounds of interest in a recombinant microorganism. In particular, the present invention relates to using a recombinant microorganism comprising a heterologous nucleic acid encoding one or more mycosporine-like amino acid (MAA) biosynthetic enzymes (e.g., MysH) to produce compounds of interest. Compositions comprising compounds produced using such methods are also provided herein. The present disclosure also provides methods of preventing sunburn, cancer, and chronic inflammatory diseases by administering such compositions to subjects in need thereof.