CAS: 50700-49-7; N-(4-Oxocyclohexa-2,5-Dien-1-Ylidene)Acetamide

上下游产品

CAS号103-90-2 对乙酰氨基苯酚 | CAS号63975-21-3 N-hydroxyacetam... | CAS号696-33-3 碘酰苯 | CAS号123-30-8 对氨基苯酚 | CAS号37398-23-5 S-甲基-3-硫代对乙酰氨基酚 | CAS号103-90-2 对乙酰氨基苯酚 | CAS号3964-54-3 N-(3-氯-4-羟基苯基)乙酰胺 | CAS号106-51-4 苯醌 | CAS号60-35-5 乙酰胺 | CAS号7403-75-0 N-(4-hydroxy-2-...

📜对乙酰氨基酚置于高氯酸,1,10-菲罗啉,[(Manganese(Iv))3(1,10-Phenanthroline)4(μ-O)4(H2O)2](Nitrate)4^2.5H2O,Sodium Perchlorate体系中,用 水 作为反应溶剂,化学反应生成 N-乙酰苯醌亚胺
参考文献:Mn(Iv)3 络合物氧化对乙酰氨基酚和咖啡因的动力学见解
标题:Mn(Iv)3 络合物氧化对乙酰氨基酚和咖啡因的动力学见解
摘要:已在室温下研究了apap和cafn由 Mn(Iv)氧化剂[mn Iv 3 (µ-O) 4 (Phen) 4 (H2O) 2] 4+ (1)氧化反应的动力学温度.在酸性反应条件下([h +] = 0.2-1.0 M),Apap和cafn与其共轭酸apap H +和cafn H +处于平衡状态,并且每种物质都充当潜在的还原剂.动力学观察表明,观测到的速率常数,K O值随着介质酸度和离子强度i 的增加而增加.氧化两种还原剂(apap H +和cafn H +)的质子化形式的二级速率常数值分别评估为6.04 +/-0.29 和0.18 +/-0.01 M-1 S-1.总体而言,在酸性介质下,Mn(Iv)-复合物有效地将apap氧化为苯醌和乙酰胺的混合物(或醌肟和乙酸),并将cafn 氧化为1,3,7-三甲基尿酸.
DOI:10.1007/s11243-021-00474-4

专利信息

专利号:US-6806291-B1
优先权日:2003-10-09
标 题:Analgesic compounds, their synthesis and pharmaceutical compositions containing them
发明人：SUNKEL CARLOS; ALVAREZ-BUILLA JULIO; BAZAN NICOLAS G; VACCARINO ANTHONY
权利人:FOUNDATION FOR THE LSU HEALTH
摘要:New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These compounds surprisingly possess high analgesic activity with little hepatotoxic effect, making them more useful than conventional non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of chronic pain.

专利号:US-2011150843-A1
优先权日:2009-10-30
标 题 :Method for the therapeutic correction of hemophilia a by transplanting bone marrow cells
发明人：MUKHOPADHYAY ASOK; YADAV NEELAM
权利人:NAT INST IMMUNOLOGY
摘要:The transdifferentiation of bone marrow cells (BMCs) into hepatocytes can be used for the development of cellular medicine for degenerative and genetic diseases. Since the liver is the primary site of factor VIII (FVIII) synthesis, the partial replacement of mutated liver cells by healthy cells in hemophilia A (HA) could manage the severity of the bleeding disorder. The use of BMCs could be used as a therapy for the bleeding phenotype of hemophilia A and other related disorders.

专利号:US-10064908-B2
优先权日:2016-03-03
标题 :Method for preventing, improving or treating liver disease
发明人：LEE YOUNG MI; KIM DAE KI; KI HYEON HUI; LEE HOON YEON
权利人:UNIV WONKWANG CT IND ACAD COOP
摘要:The present invention provides a method for preventing, alleviating or treating a liver disease, comprising administering a composition comprising a Triticum aestivum Lamarck leaf extract or a fraction thereof to a subject in need thereof. Therefore, the method for preventing, alleviating or treating a liver disease of the present invention can improve the morphological change of liver tissue due to liver injury, inhibit apoptosis of hepatocytes, increase the synthesis of antioxidant enzymes such as glutathione (GSH) and superoxide dismutase (SOD) which can reduce oxidative stress in liver tissue, and reduce the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) which are known to change sensitively in liver diseases.

专利号:US-8722864-B2
优先权日:2010-07-22
标 题 :Glycosylated acetaminophen pro-drug analogs
发明人：SHULL BRIAN; BALDWIN JOHN; GOPALASWAMY RAMESH; HAROON ZISHAN
权利人:SHULL BRIAN; BALDWIN JOHN; GOPALASWAMY RAMESH; HAROON ZISHAN; NUTEK PHARMA LTD
摘要:The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug analogs of the analgesic acetaminophen. This invention relates to a method for the production of a broad group of glycosides of acetaminophen derivatives.

专利号:WO-2006044957-A2
优先权日:2004-10-19
标题 :Porous photonic crystal with light scattering domains and methods of synthesis and use thereof