CAS: 507-52-8; 1,1,1-Trifluoro-2-Methylpropan-2-Ol

该化合物是一种含氟酒精,其特点是存在3个氟原子和三级酒精功能组;这种化合物在室温时是一种无色液体,与非氟酒精相比,其沸点相对较低;其分子结构包括一个碳原子中央原子,它与3个氟原子和1个羟基组(OH)相连接,这助长了其独特的化学特性;氟的出现加强了其稳定性,使其反应能力比许多其他酒精要小.此外,已知1,1,1-1-三氟-2-甲基-2-丙醇的表面紧张性和高度极性,可影响其溶解剂中的溶性.它经常用于专门用途,包括用作有机合成和氟化化合物生产的溶剂.由于其氟的特性,它也可能表现出低毒性和环境持久性,因此在实验室环境中必须小心处理.

结构式图片

相似化合物

1515-14-6 2378-02-1 17628-73-8

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ECHA物质ECHA物质C&L通报REACH预注册

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CAS号374-11-8 2-Methyl-2-(tri... | CAS号917-64-6 甲基碘化镁 | CAS号421-50-1 1,1,1-三氟丙酮(TFK) | CAS号2923-18-4 三氟乙酸钠 | CAS号67-64-1 丙酮 | CAS号683-78-3 lithium,1,1,2-t... | CAS号354-32-5 三氟乙酰氯 | CAS号75-16-1 甲基溴化镁 | CAS号351-70-2 Benzyl trifluor... | CAS号374-00-5 2-(三氟甲基)丙烯

合成工艺路线路线简述

    📜2-Methyl-2-(Trifluoromethyl)Oxirane置于镍 氢气体系中,用 乙醚 作为反应溶剂,化学反应生成 2-三氟甲基-2-丙醇
    参考文献:Effects Of Perfluoroalkyl Groups On Adjacent Functions
    标题:Effects Of Perfluoroalkyl Groups On Adjacent Functions
    摘要:
    DOI:10.1021/jo01071A029

    海关参考信息

    专利信息


    专利号:US-2008280855-A1
    优先权日:2005-06-22
    标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
    发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
    权利人:NYCOMED GMBH
    摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

    专利号:US-8487109-B2
    优先权日:2007-07-03
    标题:Process for the palladium-catalyzed coupling of terminal alkynes with aryl tosylates
    发明人：RKYEK OMAR; NAZARE MARC; LINDENSCHMIDT ANDREAS; URMANN MATTHIAS; HALLAND NIS; ALONSO JORGE
    权利人:RKYEK OMAR; NAZARE MARC; LINDENSCHMIDT ANDREAS; URMANN MATTHIAS; HALLAND NIS; ALONSO JORGE; SANOFI SA
    摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), n nwherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process for aryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional aryl-1-alkynes of the formula I.

    专利号:US-8420812-B2
    优先权日:2007-07-03
    标题:Process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates
    发明人：RKYEK OMAR; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; URMANN MATTHIAS; HALLAND NIS
    权利人:RKYEK OMAR; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; URMANN MATTHIAS; HALLAND NIS; SANOFI SA
    摘要:A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates n The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), n nwherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.

    专利号:US-9845282-B1
    优先权日:2016-08-12
    标题 :Palladium catalyzed synthesis of ester compounds
    发明人：EL ALI BASSAM M; IBRAHIM MANSUR B; SULEIMAN RAMI K
    权利人:UNIV KING FAHD PET & MINERALS
    摘要:A catalytic process for synthesizing an ester compound, and a catalytic process for synthesizing an amide compound, wherein a solid-supported palladium catalyst is used to catalyze an alkoxycarbonylation reaction of an aryl halide to form the ester compound, or to catalyze an aminocarbonylation reaction of an aryl halide to form the amide compound. Various embodiments of each of the processes are also provided.

    专利号:WO-2007141253-A1
    优先权日:2006-06-07
    标 题 :Process for the production of intermediates for the preparation of tricyclic imidazopyridines
    发明人：PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
    权利人:NYCOMED GMBH; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
    摘要:The invention relates to a process for the synthesis of compounds of the formula (1-a) and compounds of the formula (1-b). The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Arom have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

    专利号:US-10995078-B2
    优先权日:2013-03-13
    标 题:Compounds and compositions for inhibition of FASN
    发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
    权利人:FORMA THERAPEUTICS INC
    摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

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    合成参考文献


    摘要:Il'chenko, A. Y., Science of Synthesis, (2005) 18, 1140.
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