CAS: 4919-33-9; 4-Ethoxyphenylacetic Acid

该化合物是一种芳香的碳酸,其特点是存在一个乙氧基和一种附于乙酸酸酸的苯环,这种化合物一般是无色的,可粉黄的液体或固体,视其纯度和温度而定,在乙醇和乙醚等有机溶剂中溶解,但其溶液在水中的溶解性因乙氧基和苯成分的疏水性而受到限制; 氨基酸功能组的存在具有酸性,允许其参与各种化学反应,包括酯化和恐吓; 4-乙基苯乙酸可用于有机合成,制药和生产其他化学化合物的中间体; 安全数据表明,与许多有机酸一样,应谨慎处理,因为它可能会对皮肤和眼睛造成刺激.应当遵循适当的储存和处理程序,以确保实验室和工业环境中的安全.

结构式图片

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ECHA物质C&L通报REACH预注册

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CAS号40784-88-1 4-乙氧基苯乙酸乙酯 | CAS号64-67-5 硫酸二乙酯 | CAS号156-38-7 对羟基苯乙酸 | CAS号622-60-6 4-甲基苯乙醚 | CAS号4947-83-5 2-(4-ethoxyphen... | CAS号6775-77-5 4-乙氧基苯乙腈 | CAS号14191-95-8 对羟基苯乙腈 | CAS号1197-55-3 对氨基苯乙酸 | CAS号75-03-6 碘乙烷 | CAS号860368-91-8 4',7-diethoxy-5... | CAS号40784-88-1 4-乙氧基苯乙酸乙酯 | CAS号33468-13-2 2-(2-Chlorophen... | CAS号33468-15-4 反式-4-辛基-Alpha-氯... | CAS号55154-71-7 N-[2-(2-diethyl...

合成工艺路线路线简述

    对羟基苯乙腈置于potassium Carbonate体系中,化学反应生成 4-乙基氧丙基乙酸酯
    参考文献:Werner,Justus Liebigs Annalen Der Chemie,1902,Vol. 322,P. 160
    标题:Werner,Justus Liebigs Annalen Der Chemie,1902,Vol. 322,P. 160

    海关参考信息

    专利信息


    专利号:US-6664282-B2
    优先权日:1999-09-17
    标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
    发明人:ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
    权利人:TORREY PINES INST
    摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

    专利号:US-5856107-A
    优先权日:1997-02-04
    标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
    发明人:OSTRESH JOHN M; HOUGHTEN RICHARD A
    权利人:TREGA BIOSCIENCES INC
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.

    专利号:US-7390801-B2
    优先权日:1996-12-23
    标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
    发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
    权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
    摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

    专利号:WO-9834113-A1
    优先权日:1997-02-04
    标题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
    发明人:OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; HOUGHTEN RICHARD A; BLONDELLE SYLVIE E; SCHONER CHRISTA C
    权利人:TREGA BIOSCIENCES INC
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

    专利号:US-6359144-B1
    优先权日:1997-02-04
    标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
    发明人:OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
    权利人:LION BIOSCIENCE AG
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

    专利号:US-5786448-A
    优先权日:1996-11-07
    标题:Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
    发明人:NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD
    权利人:TREGA BIOSCIENCES INC
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.
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    合成参考文献


    参考文献:10.1208/s12248-010-9191-3
    摘要:Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA. Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library. The AAPS Journal. 2010 Apr 27;12(3):318–29. doi: 10.1208/s12248-010-9191-3.
    参考文献:10.1007/978-1-4020-9787-4_22
    摘要:Martin R. Addendum 2005–2008. 2011. In: Aromatic Hydroxyketones: Preparation and Physical Properties.
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