CAS: 447-61-0; 2-(Trifluoromethyl)Benzaldehyde

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CAS号201230-82-2 carbon monoxide | CAS号444-29-1 2-碘三氟甲苯 | CAS号346-06-5 邻三氟甲基苯甲醇 | CAS号116063-84-4 2-[2-(trifluoro... | CAS号392-83-6 邻溴三氟甲苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号312-94-7 2-三氟甲基苯甲酰氯 | CAS号3038-48-0 2-三氟甲基苯乙酸 | CAS号93-61-8 N-甲基甲酰苯胺 | CAS号647-44-9 7H-十二氟庚醛 | CAS号111716-77-9 4,5-diphenyl-2-... | CAS号312-94-7 2-三氟甲基苯甲酰氯 | CAS号344-96-7 2-(三氟甲基)苯甲酸甲酯 | CAS号433-97-6 邻三氟甲基苯甲酸 | CAS号21235-67-6 1-(2-(三氟甲基)苯基)丙-2-酮 | CAS号207981-50-8 2,6-二氟扁桃酸 | CAS号339-93-5 [2-(trifluorome... | CAS号53960-62-6 1-(2-三氟甲基苯基)-2-硝基乙烯 | CAS号727-99-1 2-(三氟甲基)苯甲酮 | CAS号727-98-0 2-(三氟甲基)二苯甲醇

2-三氟甲基苯甲酰氯置于2,6-二叔丁基-4-甲基吡啶,Lithium Tri-T-Butoxyaluminum Hydride,三乙胺体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 7.0H,反应生成 邻三氟甲基苯甲醛
参考文献:立体选择n,N-二异丙基酰胺对醛的化学选择性还原
标题:立体选择n,N-二异丙基酰胺对醛的化学选择性还原
摘要:已经开发出一种用于化学选择性地将空间上需要的n,N-二异丙基酰胺还原成醛的顺序一锅法.在该反应中,酰胺用etotf活化形成酰亚胺,然后用lialh(or)3 [r = T-Bu,Et]还原,通过水解所得到的半缩醛产生醛.非亲核碱基2,6-Dtbmp显着提高了反应效率.发现etotf / 2,6-Dtbmp和lialh(o-T-Bu)3的组合对于还原烷基,烯基,炔基和2-单取代的芳基n,N-二异丙基酰胺是最佳的.相反,Etotf和lialh(oet)3在没有碱的情况下,发现其对于还原空间上要求极高的2,6-二取代的n,N-二异丙基苯甲酰胺是最佳的.该反应可耐受各种可还原的官能团,包括醛和酮.1 H NMR研究证实了在水中稳定形成的酰亚胺.这种方法的综合实用性通过n,N-二异丙基酰胺定向的邻位金属化和ch键的活化得到了证明.
DOI:10.1021/acs.Joc.7B02868

专利信息

专利号:WO-2015109451-A1
优先权日:2014-01-22
标 题 :Synthesis of compounds containing 8-oxa-3-azabicyclo (3.2.1)octane ring
发明人：LI PENG; DECAMPO FLORYAN; SHI FENG; CUI XINJIANG; YUAN HANGKONG
权利人:RHODIA OPERATIONS; LANZHOU INSTITUTION OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCE
摘要:The present invention mainly pertains to catalytic processes for the direct amination of 2, -bis(hydroxymethyl) tetrahydrofuran to obtain compounds containing the 8-oxa-3-azabicyclo (3.2.1) octane ring, in the presence of: a homogenous catalyst which is a complex comprising at least one element selected from the group consisting of Iridium or Ruthenium and at least one donor ligand, or a heterogeneous catalyst comprising at least one Group 8-11 transition metal element and one poor metal element in the p-block of the period table.

专利号:US-7964743-B2
优先权日:2005-02-17
标 题:Catalyst for asymmetric synthesis, ligand for use therein, and process for producing optically active compound through asymmetric synthesis reaction using them
发明人：MIYAURA NORIO; YAMAMOTO YASUNORI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:Compounds represented by the following general formula (1a) or (1b). n nA complex comprising a center metal of rhodium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for optically active beta-substituted carbonyl compound synthesis and catalyst for asymmetric 1, 2 addition reaction being composed of the complex. A method of production of an optically active beta-aryl compound from an alpha, beta-unsaturated compound and an aryl-boronic acid derivative and method of production of an optically active aryl alcohol compound from an aldehyde compound and aryl boronic acid derivatives using the catalyst. A complex comprising a center metal of palladium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for asymmetric allylic substitution reaction being composed of the complex. A method of production of an optically active dialkyl (1,3-disubstituted propeny)malonate compound from a 1,3-disubstituted ally acetate compound and a dialkyl malonate and method of production of an optically active allylamine compound from a 1,3-disubstituted ally acetate compound and an amine compound. The compounds have not only the versatility of being usable in the synthesis of wide-ranging optically active aryl compounds but also the selectivity and reactivity permitting synthesis with high yield within a short period of time under industrially advantageous mild conditions.

专利号:US-8202985-B2
优先权日:2005-10-31
标 题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection
发明人：DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H
权利人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO
摘要:Nucleotide monomers, polynucleotides, methods of making each, and methods of deprotecting each, are disclosed. An embodiment of the nucleotide monomer, among others, includes a nucleotide monomer having a heterobase protecting group selected from structures I through III as described herein. An embodiment of the polynucleotide, among others, includes a plurality of nucleotide moieties having a heterobase protecting group selected from one of structures I through III as described herein.

专利号:US-7759471-B2
优先权日:2005-10-31
标题 :Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection
发明人：DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINE; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC; UNIV COLORADO
摘要:Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein.

专利号:WO-03068204-A1
优先权日:2002-02-14
标 题 :Synthesis of substituted sulfonyl amines
发明人：BUSCHMANN HELMUT; PUETZ CLAUDIA
权利人:GRUENENTHAL GMBH; BUSCHMANN HELMUT; PUETZ CLAUDIA
摘要:The invention relates to substituted sulfonyl amines, to a method for the production thereof, to medicaments containing the inventive substituted sulfonyl amines and to the use of said sulfonyl amines for producing medicaments for treating pain.

专利号:US-8394934-B2
优先权日:2008-03-21
标 题:Method and process for synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides
发明人：HUANG ZHEN; SHENG JIA
权利人:HUANG ZHEN; SHENG JIA
摘要:A method is disclosed for synthesizing 2′,3′-didehydro-2′,3′-dideoxynucleosides (d4Ns) from a nucleophile-mediated elimination, such as a telluride-mediated elimination reaction. After substitution of 2,2′-anhydronucleosides with a nucleophile, such as a telluride monoanion, a telluride intermediate is formed, and its elimination leads to formation of the olefin products (d4Ns). This disclosure describes this telluride-assisted (or nucleophile-assisted) reaction and how to facilitate the substitution and elimination in order to form d4Ns.