📜丙酸乙酯置于sodium Bromate,Sodium体系中,化学反应生成2-乙基-2-羟基丁酸 参考文献:One-Flask Preparation Of Symmetrical Ketones And 1,2-Diketones From Esters 标题:One-Flask Preparation Of Symmetrical Ketones And 1,2-Diketones From Esters 摘要:据报道,利用钠金属诱导的酰化醇缩合反应,随后与亚硫酰氯反应,可以方便地在一瓶中制备一系列对称型1,2-二酮.当初步的酰化醇缩合反应完成后,通过与水合次溴酸钠氧化,再与亚硫酰氯反应,可以获得对称的一元酮.本文讨论了制备方面的细节,反应的应用范围以及提出的反应机制. Doi:10.1055/s-1991-28415
专利号:EP-0548237-B1 优先权日:1990-09-10 标 题:Method for the production of an article from the Copolymer of Lactide and (e)-Caprolactone for medical applications 发明人:GRIJPMA DIRK WYBE; PENNINGS ALBERT JOHAN 权利人:UNIV GRONINGEN 摘要:The invention relates to a method for the production of an article from a copolymer of lactide and epsilon -caprolactone for medical applications, in which method the copolymer is obtained by a synthesis which is carried out as a bulk synthesis at a temperature of 80 to 160 DEG C. Articles according to the invention can be used in numerous fields, but are in particular advantageous if they are employed in biomedical fields. Examples are an implant for the repair of a meniscus or a blood vessel, stents or artificial skin. Stents are small spirals which are used to hold open (coronary) arteries which have silted up. Use in abdominal wall reconstruction is also possible.
专利号:EP-3661901-B1 优先权日:2017-08-02 标 题:Synthesis of glycols via transfer hydrogenation of alpha-functional esters with alcohols
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:US-7196230-B2 优先权日:2002-03-11 标 题 :Phosoxophite ligands and use thereof in carbonylation processes 发明人:PENG WEI-JUN; BRYANT DAVID ROBERT 权利人:UNION CARBIDE CHEM PLASTIC 摘要:A novel organophosphorus composition and synthesis thereof, the composition being characterized by one phosphite moiety, one phosoxophite moiety, and a plurality of sterically bulky substituents. The novel composition finds utility as a ligand in Group VIII transition metal phosoxophite complex catalysts and complex catalyst precursors that are used in carbonylation processes, preferably, hydroformylation processes. Additionally, there is disclosed a novel method of preparing a phosphoromonochloridite composition that finds utility as a precursor to the novel phosoxophite composition.
专利号:RU-2176645-C2 优先权日:1995-07-06 标 题:Thrombin inhibitors, pharmaceutical composition based on thereof, method of treatment, method of their synthesis (versions) and protected derivative
参考文献:10.1007/s12035-024-04429-5 摘要:Baghel R, Maan K, Dhariwal S, Kumari M, Sharma A, Manda K, Trivedi R, Rana P. Mild Blast Exposure Dysregulates Metabolic Pathways and Correlation Networking as Evident from LC-MS-Based Plasma Profiling. Mol Neurobiol. 2025 Mar;62(3):3143–66. doi: 10.1007/s12035-024-04429-5. 参考文献:10.1186/s12870-025-06340-0 摘要:Liu Y, Ling W, Li Y, Zhou Y, Li J, Chen S, Zhou J, Yang F. Inoculation of Lactobacillus parafarraginis enhances silage quality, microbial community structure, and metabolic profiles in hybrid Pennisetum. BMC Plant Biol. 2025 Mar 13;25(1):325. 参考文献:10.1007/s12011-025-04641-x 摘要:Marchi S, Repke K, Sunde G, Wilkes E, Kovitch K, McMillan R, Stallings D, Vincent JB, Woski SA. Do Ternary DNA-Cr(III)-Small Molecule Adducts Form Biol Trace Elem Res. 2025 May 01;203(12):6292–309. doi: 10.1007/s12011-025-04641-x. 参考文献:10.1186/s12866-025-04009-0 摘要:Hong G, Zhao Y, Zhou J, Hu L, Li G, Jin Y. Circadian rhythm perturbation causes IBS-like characteristics and altered fecal metabolome in mice. BMC Microbiol. 2025 May 07;25(1):274.