CAS: 2034-22-2; 2,4,5-Tribromoimidazole

该化合物是一种含有分子式C3HBR3N2的溴化杂环化合物,它是有机合成的多用途中间体,特别是在生产药品,农用化学品和特殊化学品方面.三个溴原子的存在增强了其反应性,有助于通过交叉或核生殖替代反应进一步发挥作用.其非二氮核心有助于其稳定性和与一系列反应条件的兼容性.该化合物因其高纯度和在合成应用方面,特别是在开发用于高级材料和生物活性分子研究的溴化衍生物方面,具有一贯的性能而受到重视.

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31250-80-3 64591-03-3 219814-29-6

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合成工艺路线路线简述

    📜咪唑置于teatb,Calcium Carbonate体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 2.0H,以45%的收率获得2,4,5-三溴咪唑
    参考文献:以硝酸铈 (Iv) 铵 (Can) 为氧化剂绿色合成四烷基三溴化铵
    标题:以硝酸铈 (Iv) 铵 (Can) 为氧化剂绿色合成四烷基三溴化铵
    摘要:摘要 铈 (Iv) 硝酸铵 (Can) 在更环保的反应条件下以水用作溶剂介导溴化四烷基铵氧化为四烷基三溴化铵.该方法简单,方便,环境友好,可用于高产率合成四烷基三溴化铵.
    Doi:10.1080/00397910601163794

    专利信息


    专利号:US-6809195-B1
    优先权日:2000-08-16
    标 题:Process for the preparation of oligonucleotides
    发明人:SANGHVI YOGESH S; SONG QUANLAI
    权利人:ISIS PHARMACEUTICALS INC
    摘要:The present invention discloses methods for synthesizing oligomeric compounds. The methods include a modified phosphoramidite protocol wherein the oxidation and capping steps are combined into a single step. The methods result in increased efficiency and are especially amenable to the large scale synthesis of oligomeric compounds.

    专利号:US-7579459-B2
    优先权日:2005-12-12
    标 题 :Activator bound solid supports for nucleic acid synthesis via the phosphoramidite approach
    发明人:NGO NAM Q; JAQUINOD LAURENT
    权利人:NGO NAM Q; JAQUINOD LAURENT
    摘要:The present invention relates to improved methods for the preparation of nucleic acids. More particularly, conventional solid supports used for nucleic acid synthesis are derivatized with activators having pKas within the 4 to 7 range. Preferentially, CPG-based solid supports are reacted with trialkoxysilanes containing an activator moiety such as pyridine. During each deblocking step of the nucleic acid synthesis cycle, bound pyridiniums are generated, yielding a weak acidic medium spreads throughout the solid support. The bound activators efficiently activate the phosphoramidite reagents towards coupling with 5′-hydroxynucleosides bound to the solid supports, thus eliminating or supplementing external deliveries of activator during the coupling steps.

    专利号:RU-2141321-C1
    优先权日:1994-03-04
    标题:Use of imidazole derivatives for preparing pharmaceutical composition showing activity to angiotensin receptors at1 and at2, some of these compounds, method of synthesis of imidazole derivatives and pharmaceutical composition based on thereof

    专利号:US-6762281-B2
    优先权日:2000-09-08
    标题:Process for preparing peptide derivatized oligomeric compounds
    发明人:MANOHARAN MUTHIAH; GUZAEV ANDREI P
    权利人:ISIS PHARMACEUTICALS INC
    摘要:Methods of preparing peptide linked oligomeric compounds are provided. The method is useful for preparing larger scale amounts of peptide linked oligomeric compounds. More particularly, the synthesis of peptide linked oligomeric compounds is performed without the problems of aggregation associated with electrostatic interactions. The present method describes using equimolar amounts of oligomeric compounds and peptide reagents providing for an increase in overall efficiency.

    专利号:RU-2174513-C2
    优先权日:1994-03-04
    标 题 :Tetrasubstituted derivatives of imidazole, methods of their synthesis, intermediate compounds and pharmaceutical composition

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: M Muneer, Et Al. Semiconductor-Mediated Photocatalysed Degradation Of Two Selected Pesticide Derivatives, Terbacil And 2,4,5-Tribromoimidazole, In Aqueous Suspension. Water Sci Technol. 2001;44(5):331-7.
    [参考文献]: R D Verschoyle, Et Al. The Relationship Between Uncoupling Of Oxidative Phosphorylation And Neuronal Necrosis Within The Cns In Rats Dosed With Trihalogenated Imidazoles. Toxicol Appl Pharmacol. 1987 Jun 30;89(2):175-82.
    [参考文献]: R D Verschoyle, Et Al. The Toxicity And Neuropathology Of 2,4,5-Tribromoimidazole And Its Derivatives In Rats. Arch Toxicol. 1984 Dec;56(2):109-12.
    [参考文献]: Tun-Cheng Chien, Et Al. Synthesis And Antiviral Evaluation Of Polyhalogenated Imidazole Nucleosides: Dimensional Analogues Of 2,5,6-Trichloro-1-(Beta-D-Ribofuranosyl)Benzimidazole. J Med Chem. 2004 Nov 4;47(23):5743-52.

    合成参考文献


    摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#05092
    摘要:Archives of Toxicology., 56(109), 1984 []
    摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2026).
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