CAS: 19056-41-8; 3-Bromo-4-Methoxyaniline

上下游产品

CAS号5197-28-4 2-溴-4-硝基苯甲醚 | CAS号6943-73-3 N-(3-溴-4-甲氧基苯基)乙酰胺 | CAS号7439-89-6 铁粉 | CAS号104-94-9 对甲氧基苯胺 | CAS号10025-69-1 氯化亚锡 | CAS号51-66-1 4'-甲氧基乙酰苯胺 | CAS号99-59-2 2-氨基-4-硝基苯甲醚 | CAS号2314-80-9 2,5-Pyrrolidine... | CAS号102236-13-5 3-bromo-4-metho... | CAS号152946-38-8 6-氨基-2-溴-3-甲氧基苯甲酸 | CAS号80689-47-0 5-Bromo-6-Metho... | CAS号6943-73-3 N-(3-溴-4-甲氧基苯基)乙酰胺 | CAS号38824-11-2 (2-氨基苯基)(3-甲氧基苯基)甲酮

2-溴苯甲醚置于硫酸,盐酸羟胺,盐酸,Titanium(III) Chloride体系中,用 乙腈,水 用作溶剂,化学反应 0.17H,以70%的收率获得3-溴-4-甲氧基苯胺
参考文献:Ch芳烃与羟胺的胺化反应.
标题:Ch芳烃与羟胺的胺化反应.
摘要:这封信描述了钛iii介导的芳烃与羟胺的ch胺化反应的发展.该反应适用于多种富电子(杂)芳烃底物,包括一系列天然产物和药物.它具有温和的条件(室温),快速的反应速率(<30分钟),与环境湿度和空气的相容性,可扩展性以及使用廉价的商业试剂的优势.
Doi:10.1021/acs.Orglett.0C00598

专利信息

专利号:WO-2024028893-A1
优先权日:2022-08-01
标 题:Substituted benzimidazoles for treating viral diseases
发明人：CHAUDHARI VINOD DINKAR; THAKUR KRISHAN GOPAL; RINGE RAJESH PRAKASH; SINGH DESHKANWAR; KAUR SIMRAN; CHAWLA RAVNEET SINGH; JOSHI AKSHAY
权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S
摘要:The invention relates to benzimidazole compounds, pharmaceutically acceptable salts thereof and its pharmaceutical compositions for reducing/treating viral infections. The present invention also relates to synthesis of such benzimidazole compounds. The present invention further relates to compositions which comprise such benzimidazole compounds or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination. The compounds of the invention are useful in reducing/treating viral infections particularly coronavirus infections caused by SARS-CoV, MERS-CoV and SARS-CoV-2.

专利号:US-10793557-B2
优先权日:2018-04-03
标题 :Sting agonist compounds
发明人：ALTMAN MICHAEL D; CASH BRANDON D; CHILDERS MATTHEW LLOYD; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW MARC; HENDERSON TIMOTHY J; JEWELL JAMES P; LARSEN MATTHEW A; LIM JONGWON; LU MIN; OTTE RYAN D; TROTTER BENJAMIN WESLEY
权利人:MERCK SHARP & DOHME
摘要:Compounds of general formula (I), of general formula (II), of general formula (III), of general formula (IV), of general formula (V), of general formula (VI), and their pharmaceutically acceptable salts, wherein all variables are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

专利号:US-2022259212-A1
优先权日:2019-07-11
标题:Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
发明人：BOSS CHRISTOPH; CREN SYLVAINE; KIMMERLIN THIERRY; LOTZ-JENNE CARINA; POTHIER JULIEN; TIDTEN-LUKSCH NAOMI
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in the treatment of inter alia cancer is disclosed.

专利号:US-11702430-B2
优先权日:2018-04-03
标 题:Aza-benzothiophene compounds as STING agonists
发明人：ALTMAN MICHAEL D; CASH BRANDON D; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW M; JEWELL JAMES P; LARSEN MATTHEW A; LU MIN; OTTE RYAN D; TAOKA BRANDON M; TROTTER BENJAMIN WESLEY; TRUONG QUANG T
权利人:MERCK SHARP & DOHME LLC; ALTMAN MICHAEL D; CASH BRANDON D; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW M; JEWELL JAMES P; LARSEN MATTHEW A; LU MIN; OTTE RYAN D; TAOKA BRANDON M; TROTTER BENJAMIN WESLEY; TRUONG QUANG T
摘要:Compounds of general formula (I), and their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 5 , R 6 , R 8 , R 9 , A, X 1 , X 2 , and X 3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

专利号:US-2005026965-A1
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides

专利号:US-9738661-B2
优先权日:2006-10-27
标题:HCV NS3 protease inhibitors
发明人：LIVERTON NIGEL J; SUMMA VINCENZO; HARPER STEVEN; MCCAULEY JOHN A; ROMANO JOSEPH J; RUDD MICHAEL T
权利人:MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.