CAS: 18423-69-3; Cubebin

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📜荜澄茄内酯置于二异丁基氢化铝体系中,用 二氯甲烷,环己烷 用作溶剂,化学反应 0.33H,以20%的收率获得
参考文献:(-)-的全合成bicubebin A,B,(+)-Bicubebin C和结构重新分配(-)-顺式-Cubebin
标题:(-)-的全合成bicubebin A,B,(+)-Bicubebin C和结构重新分配(-)-顺式-Cubebin
摘要:通过(-)-立方二聚体的二聚化,实现了(-)-立方双聚体a的首次全合成以及两个以前未报道的双木脂素(-)-立方双聚体b和(+)-立方双聚体c,从而确认了结构和绝对立体化学(-)-Bicubebin A的数据分析.结果表明,该化合物与报道的化合物(-)-顺式-Cubinbin匹配.随后合成的顺式立方结构的NMR数据证实其原始结构是错误的.
Doi:10.1021/acs.Orglett.7B02644

专利信息

专利号:US-2008194678-A1
优先权日:2005-07-15
标 题:Process To Obtain Synthetic And Semi-Synthetic Lignan Derivatives, Their Antiparasitic Activities And Corresponding Pharmaceutical Formulations, Including The Therapeutic Method Using Said Lignan For The Treatment Of Parasitosis
发明人：SILVA MARCIO LUIS ANDRADE E; SILVA ROSANGELA DA; RODRIGUES VANDERLEI; PEREIRA OLAVO DOS SANTOS; SILVA FILHO ADEMAR ALVES DA; DONATE PAULO MARCOS; ALBUQUERQUE SERGIO; BASTOS JAIRO KENUPP
权利人:FUNDACAO DE AMPARO A PESQUISSA
摘要:A process to obtain synthetic and semi-synthetic derivatives of lignans, especially dibenzylbutyrolactonic, tetrahydrofuranic, aryltetralynic, furofuranic and dibenzocyclooctanic lignans obtained by means of partial synthesis and/or full synthesis or also by isolation from plant extracts. It refers to a process to obtain synthetic and semi-synthetic derivatives of (−)-cubebin, such as: (−)-O-acetylcubebin; (−)-O-methylcubebin; (−)-O—N,N-(dimethylamino-ethyl)-cubebin; (−)-hinokinin; (−)-6,6′-dinitroinokinine; (−)-O-benzylcubebin; (−)-6,6′-diaminoinokinin, (−)-6,6′-dinitroinokinin, as well as to obtain dibenzocyclooctanic lignans from dibenzylbutyrolactoinic lignans by means of structural modifications in the positions 7, 7′, 8, 8′, 9′ and in the aromatic rings (introduction and/or substitution of functional groups such as: —OH, —CO 2 H, —CO 2 CH 3 , —NO 2 , —NH 2 , —OCH 3 , —OAc, —SO 2 CH 3 , —SO 2 NH 2 , prenyl and halogens) is provided. A therapeutic method using the derivatives is also provided.