CAS: 164654-49-3; N-Bis(Phenylmethoxy)Phosphanyl-N-Methylmethanamine

该化合物是一种化学化合物,其特征是磷酰胺功能组,在有机合成中常用,特别是在核酸化学领域;该化合物的特点是与磷原子相连的两个苯基组,以及二甲基氨基组;其结构有助于其反应,使其成为酒精磷酸化和聚核素合成的一种有价值的试剂;磷酰胺混合物的存在,使得磷酰胺联结得以形成,这对DNA和RNA序列的形成至关重要;Dibenzyl N,N-二甲基磷酰胺基通常在无水条件下处理,因为其对水的敏感性可导致水解;重要的是,应注意该化合物的使用应谨慎,因为吸入或浸入可能会对健康造成危害,而且在处理和储存过程中应采取适当的安全措施.

英文名称N-Bis(Phenylmethoxy)Phosphanyl-N-Methylmethanamine
中文名称二苄基 N,N-二甲基亚磷酰胺
IUPAC名称N-bis(phenylmethoxy)phosphanyl-N-methylmethanamine
其它别名Phosphoramidousacid, dimethyl-, bis(phenylmethyl) ester (9CI)
CAS编号164654-49-3
MFCD编号:MFCD00239442
EINECS号:626-461-3
分子式:C16H20NO2P分子量:289.31
产品CID: 836624
产品分类有机原料 → 有机膦化合物

相似结构搜索
InChIKey: GDEJGFHRPXLQNN-UHFFFAOYSA-N
InChI=1S/C16H20NO2P/c1-17(2)20(18-13-15-9-5-3-6-10-15)19-14-16-11-7-4-8-12-16/h3-12H,13-14H2,1-2H3
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数7.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P271-P280-P302+P352-P305+P351+P338
UN编号NONH for all modes of transport
危险品标志Xi
安全声明26-36
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

benzyl alcohol Hexamethylphosphorous triamide (S)-2-(Bis-benzyloxy-phosphanylamino)-pentanedioic acid dibenzyl ester allyl-3,6-di-O-benzyl-4-O-(dibenzyloxyphosphoryl)-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside 2-(dibenzyloxyphosphoryloxy)ethyl-3,4-di-O-benzyl-6-O-{3,6-di-O-benzyl-4-O-(dibenzyloxyphosphoryl)-2-deoxy-2-[(R)-3-dodecanoyloxytetradecanoylamino]-β-D-glucopyranosyl}-2-[(R)-3-benzyloxytetradecanoylamino]-2-deoxy-α-D-glucopyranoside N,N-dimethyl acetamide

合成工艺路线路线简述

合成目标产物 Dibenzyl N,N-Dimethylphosphoramidite 主要起始原料 Benzyl Alcohol And Hexamethylphosphorous Triamide
(文献来源)合成步骤主要原料 Benzyl Alcohol 和 Hexamethylphosphorous Triamide

📜苯甲醇以 1,4-二氧六环,二氯甲烷用作溶剂,化学反应 42.0H,反应生成二苄基 N,N-二甲基亚磷酰胺
参考文献:Dismutation Of Arylene Phosphorodiamidites: Specific Features And Aspects Of Preparative Use
标题:Dismutation Of Arylene Phosphorodiamidites: Specific Features And Aspects Of Preparative Use
摘要:The Dismutation Ofarylene Phosphorodiamidites Derived From The Simplest Phenols And Naphthols And Of Their Dibasic Analogs Was Studied. The Main Regular Trends Of This Process And The Limits Of Its Synthetic Applicability Were Determined.
Doi:10.1134/s1070363206020046