CAS: 154-58-5; 1,5-Anhydrosorbitol

该化合物是一种天然的甘醇,在结构上与甘蔗糖有关,是一种在水中可溶解并有甜味的白色晶状固体,尽管不及糖味,但该化合物在人类代谢中所起的作用值得注意,特别是作为控制甘糖的标记,因为其血液中的含量可以反映血液中甘蔗水平的短期波动. 1,5-AHLUCITol在体内从甘蔗糖中产生,在尿液中排出,其浓度与血液甘蔗水平不相干,在正常条件下稳定,但在极小的pH或温度下可降解.除了其生理意义外,1,5-Anhmyglucitol还具有对食品科学和营养的兴趣,因为它可以用作低热液糖,并有可能用于管理糖尿病.其安全性特征一般被认为是有利的,但进一步研究正在进行,以充分了解其生物影响和潜在治疗用途.

结构式图片

相似化合物

439685-79-7 868156-46-1 154-17-6

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

1-deoxy-D-glucose tetraacetate 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 1-O-methyl-2,3,4,6-tetra-O-trimethylsilyl-β-D-glucopyranoside methyl 2,3,4,6-tetrakis-O-trimethylsilyl-α-D-glucopyranoside 2,3,4-tri-O-acetyl-1,5-anhydro-6-O-toluene-p-sulfonyl-D-glucitol 1,5-anhydro-4,6-O-(R)-benzylidene-D-glucitol (4aR,7S,8R,8aS)-2-phenylhexahydropyrano[3,2-d][1,3]dioxine-7,8-diol 1,5-anhydro-6-O-trityl-D-glucitol

合成工艺路线路线简述

    📜(2R,3R,4S,5R,6S)-2-(Acetoxymethyl)-6-(Phenylthio)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate置于raney Nickel W4 甲醇,乙醇,Potassium Carbonate体系中,化学反应 2.0H,反应生成1,5-无水葡萄糖醇
    参考文献:通过收敛环封闭复分解方法制备的基于碳水化合物的大环内酯类药物:寻找新型抗生素.
    标题:通过收敛环封闭复分解方法制备的基于碳水化合物的大环内酯类药物:寻找新型抗生素.
    摘要:已经开发出一种有效的收敛方法来构建新颖的,非天然的多取代碳水化合物基大环内酯类化合物.合成中的关键步骤是通过闭环易位反应形成大环.已经筛选了获得的大环内酯类似物对革兰氏阳性和革兰氏阴性细菌,酵母和霉菌的生物活性.
    Doi:10.1021/jo061929Q

    海关参考信息

    专利信息


    专利号:US-7435816-B2
    优先权日:2003-04-30
    标 题 :Synthesis of solanum glycosides
    发明人:SHAHID MOHAMMED
    权利人:SHAHID MOHAMMED
    摘要:The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solasonine as well as to novel β-monosaccharide intermediate compounds, of Formula (2), where R 1 is a benzylidene, 4-nitrobenzylidene or 4-methoxybenzylidine group, and each R 2 independently is a benzoyl, acetyl or pivaloyl group:

    专利号:EP-1421100-B1
    优先权日:2001-08-21
    标 题 :Chemical synthesis of solamargine
    发明人:SHAHID MOHAMMED
    权利人:GLYCOMED SCIENCES LTD
    摘要:The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solamargine as well as to novel beta-monosaccharide Intermediate compounds.

    专利号:US-2003138880-A1
    优先权日:2001-08-24
    标 题:Solid-phase synthesis of oligosaccharides and glycopeptides using glycosynthases
    发明人:WITHERS STEPHEN G; JENSEN KNUD J; PETERSEN LARS; TOLBORG JAKOB L
    权利人:UNIV BRITISH COLUMBIA
    摘要:The present invention provides materials and methods for the solid-phase synthesis of oligosaccharides and glycopeptides. Such materials and methods include mutant glycosidase enzymes, or “glycosynthases,â€? chemically-derivatized acceptor molecules, and specific solid support matrices.

    专利号:US-5856143-A
    优先权日:1993-05-14
    标 题 :N-containing saccharides and method for the synthesis of N-containing saccharides from amino-deoxy-disaccharides and amino-deoxy-oligosaccharides
    发明人:NILSSON KURT G I
    权利人:BIOFLEXIN AB
    摘要:Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted with an amino-deoxy-saccharide or a derivative thereof, and that the amino-saccharide is isolated from the product mixture directly or after chemical/enzymatic modification.

    专利号:US-5808019-A
    优先权日:1994-12-19
    标题 :Intermediate compounds for the synthesis of glycolipids
    发明人:HASEGAWA AKIRA; KISO MAKOTO; ISOGAI YUKIHIRO; KITAMURA SEIICHI; UEDA HIROSHI
    权利人:TOA BOSHOKU KABUSHIKI KAISHA
    摘要:The invention provides important intermediate compounds for the synthesis of acidic glycolipids which are identical with the glycolipid antigens isolated from the acidic glycolipid fractions of peripheral nerve and embryonic central nervous system and preparation methods thereof. By the adoption of the present intermediate compounds, sulfation of 3-hydroxyl group of end glucuronic acid portion of the acidic glycolipid can be quite easily carried out and total synthetic yield be greatly improved.

    专利号:US-9102966-B2
    优先权日:2010-07-16
    标 题:Synthesis of sialooligosaccharide derivatives
    发明人:SCHROVEN ANDREAS; CHAMPION ELISE; DEKANY GYULA; RÖHRIG CHRISTOPH; VRASIDAS IOANNIS; FIGUEROA PÉREZ IGNACIO; HEDEROS MARKUS; BOUTET JULIEN; Ã?GOSTON Ã?GNES; KOVÃ?CS-PÉNZES PIROSKA; Horváth Ferenc; RISINGER CHRISTIAN; PIPA GERGELY; DEMKÓ SÃ?NDOR; KRÖGER LARS
    权利人:SCHROVEN ANDREAS; CHAMPION ELISE; DEKANY GYULA; RÖHRIG CHRISTOPH; VRASIDAS IOANNIS; FIGUEROA PÉREZ IGNACIO; HEDEROS MARKUS; BOUTET JULIEN; Ã?GOSTON Ã?GNES; KOVÃ?CS-PÉNZES PIROSKA; Horváth Ferenc; RISINGER CHRISTIAN; PIPA GERGELY; DEMKÓ SÃ?NDOR; KRÖGER LARS; GLYCOM AS
    摘要:The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X 1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R 1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Vaarhorst Aa, Et Al. A Metabolomic Profile Is Associated With The Risk Of Incident Coronary Heart Disease. Am Heart J. 2014 Jul;168(1):45-52.E7.
    [参考文献]: Alison M Mondul, Et Al. Metabolomic Profile Of Response To Supplementation With β-Carotene In The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am J Clin Nutr. 2013 Aug;98(2):488-93.
    [参考文献]: Cornelius Hess, Et Al. Clinical And Forensic Examinations Of Glycemic Marker 1,5-Anhydroglucitol By Means Of High Performance Liquid Chromatography Tandem Mass Spectrometry. Forensic Sci Int. 2012 Oct 10;222(1-3):132-6.
    [参考文献]: Etsuko Nagai, Et Al. Effects Of Miglitol In Combination With Intensive Insulin Therapy On Blood Glucose Control With Special Reference To Incretin Responses In Type 1 Diabetes Mellitus. Endocr J. 2011;58(10):869-77.
    [参考文献]: Ji Won Yoon, Et Al. Improved Insulin Secretion By Autologous Islet Transplantation, Compared To Oral Antidiabetic Agents, After Distal Pancreatectomy. Cell Transplant. 2015;24(8):1615-26.

    合成参考文献


    参考文献:10.1007/s11130-011-0245-1
    摘要:Kosińska A, Penkacik K, Wiczkowski W, Amarowicz R. Presence of Caffeic Acid in Flaxseed Lignan Macromolecule. Plant Foods for Human Nutrition. 2011 Jul 16;66(3):270. doi: 10.1007/s11130-011-0245-1.
    参考文献:10.1016/j.bbagen.2011.06.025
    摘要:Sengupta S, Lahiri S, Banerjee S, Bashistha B, Ghosh AK. Arginine mediated purification of trehalose-6-phosphate synthase (TPS) from Candida utilis: Its characterization and regulation. Biochimica et Biophysica Acta (BBA) - General Subjects. 2011 Dec;1810(12):1346–54. doi: 10.1016/j.bbagen.2011.06.025.
    参考文献:10.1155/2011/485402
    摘要:Kim SH, Kim BK, Lee YC. Antiasthmatic effects of hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma. Mediators Inflamm. 2011;2011():485402.
    参考文献:10.4162/nrp.2011.5.3.205
    摘要:Kim SS, Koo JH, Kwon IS, Oh YS, Lee SJ, Kim EJ, Kim WK, Lee J, Cho JY. Exercise training and selenium or a combined treatment ameliorates aberrant expression of glucose and lactate metabolic proteins in skeletal muscle in a rodent model of diabetes. Nutr Res Pract. 2011 Jun;5(3):205–13.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知