专利号:US-7435816-B2 优先权日:2003-04-30 标 题 :Synthesis of solanum glycosides 发明人:SHAHID MOHAMMED 权利人:SHAHID MOHAMMED 摘要:The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solasonine as well as to novel β-monosaccharide intermediate compounds, of Formula (2), where R 1 is a benzylidene, 4-nitrobenzylidene or 4-methoxybenzylidine group, and each R 2 independently is a benzoyl, acetyl or pivaloyl group:
专利号:EP-1421100-B1 优先权日:2001-08-21 标 题 :Chemical synthesis of solamargine 发明人:SHAHID MOHAMMED 权利人:GLYCOMED SCIENCES LTD 摘要:The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solamargine as well as to novel beta-monosaccharide Intermediate compounds.
专利号:US-2003138880-A1 优先权日:2001-08-24 标 题:Solid-phase synthesis of oligosaccharides and glycopeptides using glycosynthases 发明人:WITHERS STEPHEN G; JENSEN KNUD J; PETERSEN LARS; TOLBORG JAKOB L 权利人:UNIV BRITISH COLUMBIA 摘要:The present invention provides materials and methods for the solid-phase synthesis of oligosaccharides and glycopeptides. Such materials and methods include mutant glycosidase enzymes, or “glycosynthases,â€? chemically-derivatized acceptor molecules, and specific solid support matrices.
专利号:US-5856143-A 优先权日:1993-05-14 标 题 :N-containing saccharides and method for the synthesis of N-containing saccharides from amino-deoxy-disaccharides and amino-deoxy-oligosaccharides 发明人:NILSSON KURT G I 权利人:BIOFLEXIN AB 摘要:Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted with an amino-deoxy-saccharide or a derivative thereof, and that the amino-saccharide is isolated from the product mixture directly or after chemical/enzymatic modification.
专利号:US-5808019-A 优先权日:1994-12-19 标题 :Intermediate compounds for the synthesis of glycolipids 发明人:HASEGAWA AKIRA; KISO MAKOTO; ISOGAI YUKIHIRO; KITAMURA SEIICHI; UEDA HIROSHI 权利人:TOA BOSHOKU KABUSHIKI KAISHA 摘要:The invention provides important intermediate compounds for the synthesis of acidic glycolipids which are identical with the glycolipid antigens isolated from the acidic glycolipid fractions of peripheral nerve and embryonic central nervous system and preparation methods thereof. By the adoption of the present intermediate compounds, sulfation of 3-hydroxyl group of end glucuronic acid portion of the acidic glycolipid can be quite easily carried out and total synthetic yield be greatly improved.
专利号:US-9102966-B2 优先权日:2010-07-16 标 题:Synthesis of sialooligosaccharide derivatives 发明人:SCHROVEN ANDREAS; CHAMPION ELISE; DEKANY GYULA; RÖHRIG CHRISTOPH; VRASIDAS IOANNIS; FIGUEROA PÉREZ IGNACIO; HEDEROS MARKUS; BOUTET JULIEN; Ã?GOSTON Ã?GNES; KOVÃ?CS-PÉNZES PIROSKA; Horváth Ferenc; RISINGER CHRISTIAN; PIPA GERGELY; DEMKÓ SÃ?NDOR; KRÖGER LARS 权利人:SCHROVEN ANDREAS; CHAMPION ELISE; DEKANY GYULA; RÖHRIG CHRISTOPH; VRASIDAS IOANNIS; FIGUEROA PÉREZ IGNACIO; HEDEROS MARKUS; BOUTET JULIEN; Ã?GOSTON Ã?GNES; KOVÃ?CS-PÉNZES PIROSKA; Horváth Ferenc; RISINGER CHRISTIAN; PIPA GERGELY; DEMKÓ SÃ?NDOR; KRÖGER LARS; GLYCOM AS 摘要:The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X 1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R 1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.
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合成参考文献
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