CAS: 144119-12-0; (R)-(1-Methylpyrrolidin-2-yl)Diphenylmethanol

英文名称(R)-(1-Methylpyrrolidin-2-yl)Diphenylmethanol
中文名称(R)-(-)-2-[羟基(二苯基)甲基]-1-甲基吡咯烷
IUPAC名称[(2R)-1-methylpyrrolidin-2-yl]-diphenylmethanol
其它别名2-Pyrrolidinemethanol,1-methyl-a,a-diphenyl-, (R)-; (R)-N-Methyl-a,a-diphenylprolinol
CAS编号144119-12-0
MFCD编号:MFCD00145217
EINECS号:635-081-7
分子式:C18H21NO
分子量:267.37
产品CID: 670860
产品分类生物化工 → 氨基酸及其衍生物 → 氨基醇类衍生物

相似结构搜索
InChIKey: XIJAGFLYYNXCAB-QGZVFWFLSA-N
InChI=1S/C18H21NO/c1-19-14-8-13-17(19)18(20,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17,20H,8,13-14H2,1H3/t17-/m1/s1…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数3.0

物理性质

熔点68-71 °C
沸点406.8±25.0 °C(预测)
闪点196.766 °C
密度1.116±0.06 g/cm3(预测)
PH:-52° (c=1, CHCl3)
pKa:13.15±0.29(预测)
PSA:23.47
LogP:2.9546
折射率-55 ° (C=1, CHCl3)
蒸汽压2.39E-07 mmHg at 25 °C
外观形态白色至淡黄色粉末
储存条件密封, 常温干燥保存
产品应用该化合物用于将丙烯酰胺酸添加到芳烃甲酰胺中以锌催化剂添加到阳性甲醚中,其产量较高,抗阳性很高(高达98%).
性质描述a,a-二苯基-N-甲基-D-脯氨醇(144119-12-0)的性状:的熔点是68~71°C,折射率是－5 .只需轻轻,

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P271-P280-P302+P352-P305+P351+P338
危险品标志Xi
安全声明26-36
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

1-ethyl methyl (2R)-pyrrolidine-1,2-dicarboxylate dimethyl sulfate (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

合成工艺路线路线简述

合成目标产物 (R)-Alpha,Alpha-Diphenylmethylprolinol 主要起始原料 Dimethyl Sulfate And (R)-3,3-Diphenyl-1-Methylpyrrolidino[1,2-C]-1,3,2-Oxazaborole
(文献来源)合成步骤主要原料 Dimethyl Sulfate 和 (R)-3,3-Diphenyl-1-Methylpyrrolidino[1,2-C]-1,3,2-Oxazaborole

Phenylmagnesium Bromide,二甲基(2R)-1,2-吡咯烷二羧酸酯置于lithium Aluminium Tetrahydride体系中,用四氢呋喃用作溶剂,化学反应生成(R)-(-)-2-[羟基(二苯基)甲基]-1-甲基吡咯烷
参考文献:以环硼氧烷为芳基源的催化不对称芳基转移至醛的反应
标题:以环硼氧烷为芳基源的催化不对称芳基转移至醛的反应
摘要:在衍生自(S)-脯氨酸的手性氨基醇的存在下,以高对映选择性进行了三苯基硼氧杂环丁烷向一组芳基醛的不对称芳基转移.在苯甲醛的不对称芳基化反应中,取代的苯基硼氧还用作芳基来源.
Doi:10.1016/j.Tetasy.2005.06.010

海关参考信息

2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2906210000-苄醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7692019-B2
优先权日:2000-12-04
标题:Methods for the stereoselective synthesis of substituted piperidines
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HEFFERNAN MICHELE L R; HOEMANN MICHAEL Z; KESSLER DONALD W; SHAO LIMING; WU XINHE; XIE ROGER L
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in the synthesis of compounds useful for treatment of numerous ailments, conditions and diseases that afflict mammals, including but not limited to addiction and pain. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the substituted piperidines using the methods of the present invention. An additional aspect of the present invention relates to enantiomerically substituted pyrrolidines, piperidines, and azepines.