CAS: 143059-69-2; Cefaclor Impurity C

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    R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-chloro-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid 4-nitro-benzyl ester; toluene-4-sulfonate(6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-chloro-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid 4-nitro-benzyl ester; toluene-4-sulfonate (R)-phenylglycine amide °Ct-2-ene-2-carboxylic acid(6R,7R)-1-aza-3-chloro-7-amino-8-oxo-5-thiabicyclo4.2.0°Ct-2-ene-2-carboxylic acid (R)-Phenylglycine methyl ester

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      专利号:US-2024197774-A1
      优先权日:2021-04-16
      标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
      发明人:LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
      权利人:UNIV TEXAS
      摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

      专利号:US-8557979-B2
      优先权日:2004-06-10
      标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
      发明人:CHOI WOO-BAEG; KOWALIK EWA
      权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
      摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

      专利号:US-10933051-B2
      优先权日:2017-06-09
      标 题 :Carbapenem compounds and compositions for the treatment of bacterial infections
      发明人:CHOI WOO-BAEG; TOMIOKA TAKASHI; JOO HYUNG-YEUL; TRUONG PHONG; MIN BRIAN
      权利人:FOB SYNTHESIS INC
      摘要:The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

      专利号:WO-2006008296-A1
      优先权日:2004-07-19
      标 题 :A process for the preparation of enzymatic catalysts, catalysts obtainable by this process and use thereof
      发明人:TERRENI MARCO; VACCARO SUSANNA; ESTRUCH ILONA; PREGNOLATO MASSIMO; GIANNELLI ANTONIO; CARUSO SALVATORE
      权利人:FIDIA FARMACEUTICI; INNOVATE BIOTECHNOLOGY S R L; TERRENI MARCO; VACCARO SUSANNA; ESTRUCH ILONA; PREGNOLATO MASSIMO; GIANNELLI ANTONIO; CARUSO SALVATORE
      摘要:Herein described is a process for the preparation of enzymatic catalysts immobilised on epoxidic support, particularly suitable for the synthesis of β-lactamic antibiotics; the enzymatic catalysts obtainable by this process and their use.

      专利号:US-2009111737-A1
      优先权日:1999-05-24
      标题:Novel antibacterial agents
      发明人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
      权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
      摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

      专利号:US-9937151-B2
      优先权日:2010-06-18
      标题 :Carbapenem antibacterials with gram-negative activity
      发明人:CHOI WOO-BAEG; GRUSZECKA-KOWALIK EWA; JOO HYUNG-YEUL; LIU SHUANGPEI; MAO SHULI; LI YONGFENG; KIM DEOG-IL
      权利人:FOB SYNTHESIS INC
      摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

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      合成参考文献


      摘要:Dhanasekar G, Robertson A, Nicholson K. Atypical presentation of HIV in a pregnant patient. Ulster Med J. 2006 May;75(2):160–1.
      参考文献:10.1007/bf03262708
      摘要:Salinas Noyola A, Guinot Jimeno F, Barbero Castleblanque V, Bellet Dalmau LJ. Short communication. Frequency of dispensing paediatric medicines with high sugar content by pharmacists in Barcelona. Eur Arch Paediatr Dent. 2010 Feb;11(1):38–40. doi: 10.1007/bf03262708.
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