专利号:US-8076476-B2 优先权日:2007-11-15 标 题 :Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits 发明人:REEVES MATTHEW DALE; WELLER DWIGHT D; LI YONGFU 权利人:REEVES MATTHEW DALE; WELLER DWIGHT D; LI YONGFU; AVI BIOPHARMA INC 摘要:Morpholino compounds are provided having the structure: n nwheren R 1 is selected from the group consisting of lower alkyl, di(lower alkyl)amino, and phenyl; R 2 is selected from the group consisting of lower alkyl, monocyclic arylmethyl, and monocyclic (aryloxy)methyl; R 3 is selected from the group consisting of triarylmethyl and hydrogen; and Y is selected from the group consisting of: a protected or unprotected hydroxyl or amino group; a chlorophosphoramidate group; and a phosphorodiamidate linkage to the ring nitrogen of a further morpholino compound or a morpholino oligomer. Such compounds include doubly protected morpholino guanine (MoG) monomers. Also described is their use in synthesis of morpholino oligomers.
专利号:US-2009131624-A1 优先权日:2007-11-15 标题:Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits