CAS: 112101-74-3; (R)-N-(1-(4-Methoxy-3-Sulfamoylphenyl)Propan-2-yl)Acetamide

相似化合物

116091-63-5 112101-81-2 119714-13-5

上下游产品

CAS号86073-42-9 Acetamide, N-[(... | CAS号112101-81-2 R-(-)-5-(2-氨基丙基...

📜(E)-N-(1-(4-Methoxyphenyl)Prop-1-En-2-yl)Acetamide置于氯磺酸,[rh(Nbd)((S,S,S,S)-Wingphos)]Bf4,氨,氢气体系中,用 二氯甲烷,水,乙腈 用作溶剂,50.0 °C,5.0 Mpa 条件下,反应 18.08H,反应生成N-[(1R)-2-(3-氨基磺酰基-4-甲氧基)-1-甲基]乙酰胺
参考文献:N-乙酰(e)-β-丙烯酰胺的实用合成
标题:N-乙酰(e)-β-丙烯酰胺的实用合成
摘要:摘要 通过用铁还原相应的肟,开发了一种简便实用的制备(e)-β-芳基酰胺[(e)-N-(1-芳基丙-1-烯-2-基]乙酰胺]的方法(II)乙酸盐作为还原剂发现使用六甲基磷酰胺作用作溶剂对高e / Z选择性至关重要,该方法已用于通过不对称氢化有效合成坦索罗辛的关键手性中间体. 通过用铁还原相应的肟,开发了一种简便实用的制备(e)-β-芳基酰胺[(e)-N-(1-芳基丙-1-烯-2-基]乙酰胺]的方法(II)乙酸盐作为还原剂发现使用六甲基磷酰胺作用作溶剂对高e / Z选择性至关重要,该方法已用于通过不对称氢化有效合成坦索罗辛的关键手性中间体.
Doi:10.1055/s-0033-1339976

专利信息

专利号:US-7282606-B2
优先权日:2005-07-13
标题:Process for preparation of tamsulosin and its aralkylamine derivatives
发明人：JIH RU HWU; TSAY SHWU CHEN; MAGENDRAN BALAACHARY; CHAKRABORTY SUBHASISH K; DAS ASISH R; SHEU KUEN WANG; SHU CHUN MEI; LU CHIN KUN; CHANG WEI MIN
权利人:TAIWAN BIOTECH CO LTD
摘要:The present invention discloses a new process for the synthesis of tamsulosin and its aralkylamine derivatives, especially (R)-(−)-5-{2-[2-(2-alkoxyphenoxy) ethylamino]propyl}-2-alkoxybenzenesulfonamides having the following formula 1 (where R 1 and R 2 represent C 1 -C 4 alkyl groups) and their hydrochloride thereof, and other various pharmaceutical used salts. n n n n n n n n n n Tamsulosin hydrochloride (R 1 =Et, R 2 =Me, in its hydrochloride salt form) is an antagonist of α-A adrenoceptors in the prostate. Tamsulosin•HCl occurs as white crystals, which melt with decomposition at approximately 230° C. It is sparingly soluble in water and in methanol, slightly soluble in glacial acetic acid and in ethanol, and practically insoluble in ether.

专利号:EP-1734036-B1
优先权日:2005-06-14
标 题:Process for preparation of tamsulosin and its derivatives
发明人：JIH RU HWU; MAGENDRAN BALAACHARY; CHAKRABORTY SUBHASISH K; DAS ASISH R; TSAY SHWU CHEN; SHEU KUEN WANG; SHU CHUN MEI; LU CHIN KUN; CHANG WEI MIN
权利人:WELL BEING BIOCHEMICAL CORP; TAIWAN BIOTECH CO LTD
摘要:The present invention discloses a new process for the synthesis of tamsulosin derivatives of formula 1 (where R 1 and R 2 represent C 1 -C 4 alkyl groups) and their hydrochlorides and other pharmaceutically acceptable salts, comprising reacting the hydrochloride of sulphonamide 2 (where R represents C 1 -C 4 alkyl) with the ether compound 21 (where R' represents C 1 -C 4 alkyl and R' represents MeC 6 H 4 SO 2 or MeSO 2 ).