CAS: 1116-24-1; N,N-Dipropylacetamide

该化合物是一种多用途有机化合物,配有分子式C8H17NO.由于有机合成和制药应用具有有利的溶解特性和各种反应条件下的稳定性,它通常被用作极地蛋白溶解剂,在各种反应条件下作为极地蛋白溶解剂使用.该化合物表现出多种有机和无机物质的溶解性,适合用于催化,聚合和特殊化学工艺.其相对较高的沸点和低挥发性提高了其在高温反应中的效用.此外,N,N-异丙烯酸盐与许多试剂相容,为合成转化提供了可靠的介质,同时尽量减少侧反应.

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上下游产品

acetic anhydride di-n-propylamine acetyl chloride N-(4-Nitrophenyl)acetamideN,N-Dipropylthioacatamid propionic acid

合成工艺路线路线简述

    📜Dipropylammonium Dipropylcarbamate 以 二氯甲烷 用作溶剂,化学反应 0.75H,反应生成N,N-二丙基乙酰胺
    参考文献:三甲基甲硅烷基化的n-烷基取代的氨基甲酸酯i.制备及一些反应
    标题:三甲基甲硅烷基化的n-烷基取代的氨基甲酸酯i.制备及一些反应
    摘要:三甲基甲硅烷ñ-Monoalkyl-和ñ,ñ二烷基-氨基甲酸酯已在85-95%的收率由相应的氨基甲酸铵与三甲基氯硅烷的甲硅烷基化制备.三甲基甲硅烷基n N-二甲基氨基甲酸酯可用于醇,酚和羧酸的甲硅烷基化.甲硅烷基氨基甲酸酯与羧酸卤化物反应,得到相应的酸酰胺.氨基甲酸三甲基甲硅烷基酯与羧酸酐的反应生成相应的甲硅烷基羧酸酯和酰胺,而与二羧酸酐的反应生成相应的二羧酸的三甲基甲硅烷基单酰胺,即me 3 Sio 2-Cconr 1 R2.
    Doi:10.1016/s0022-328X(00)99291-X

    海关参考信息

    专利信息


    专利号:US-3742080-A
    优先权日:1969-04-11
    标 题 :Rhodium based catalysts for the synthesis of 1,4-dienes
    发明人:SU A
    权利人:DU PONT
    摘要:Improved catalysts are provided for the synthesis of 1,4-dienes from Alpha -monoolefins and conjugated dienes. The catalysts are rhodium (III) salts in combination with amides, phosphoramides, phosphine oxides, or water. The improved catalysts allow control of the trans-cis ratio of the 1,4-diene formed and are operable at useful rates in a wide range of solvent systems, both protonic and aprotic.

    专利号:US-4161609-A
    优先权日:1977-09-14
    标题:Synthesis of carboxylic acid esters
    发明人:CRAMER RICHARD D
    权利人:DU PONT
    摘要:A method is provided for converting a carboxylic acid amide to a carboxylic acid ester by reacting a vaporized mixture of the amide and an aliphatic alcohol or a phenol in the presence of a suitable catalyst at temperatures of from 100 DEG C. to 400 DEG C. The process is especially useful for the conversion of methacrylamide to methyl methacrylate.

    专利号:US-9346850-B2
    优先权日:2006-03-01
    标题:Method of producing peptide
    发明人:MURAO HIROSHI; MORIO KEN-ICHIRO; MITSUDA MASARU
    权利人:KANEKA CORP
    摘要:The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1% or less in a liquid phase peptide synthesis method. According to the invention, a target peptide of high purity can be simply and efficiently produced by a continuous liquid phase synthesis method. Further, the present invention is related to a method of producing a peptide, characterized in using an amide-type solvent immiscible with water in a liquid phase peptide synthesis method. According to the invention, various peptides can be produced by the liquid phase synthesis method without being restricted by the amino acid sequence of the target peptide.

    专利号:US-8772301-B2
    优先权日:2009-12-18
    标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
    发明人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
    权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
    摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

    专利号:CN-105126909-A
    优先权日:2015-07-13
    标 题 :Application of Immobilized Palladium Catalyst in the Synthesis of Methyl 4-Phenylethynyl-3-nitrobenzoate

    专利号:US-3640898-A
    优先权日:1969-04-11
    标 题 :Rhodium based catalysts for the synthesis of 1 4-dienes

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1016/s0140-6736(85)91417-5
    摘要:Pacifici GM, Tomson T, Bertilsson L, Rane A. Valpromide/carbamazepine and risk of teratogenicity. Lancet. 1985 Feb 16;1(8425):397–8. doi: 10.1016/s0140-6736(85)91417-5.
    摘要:Metallinos, C., Science of Synthesis, (2006) 8, 797.
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