CAS: 96989-50-3; O,O-Di(Pyridin-2-yl) Carbonothioate

该化合物是一种有机化合物,其独特结构包括两个丙烯基环和一个硫碳酸盐功能组,具有独特的结构特征,通常是一种固体或晶体物质,以其作为各种化学反应中的试剂的作用而著称,特别是在合成其他有机化合物时.硫碳酸盐组的存在具有特定的反动作用,允许其参与核循环替代反应.该化合物由于在药物开发中的潜在应用,并作为较复杂的分子的建筑块,经常用于医药化学和材料科学领域.此外,二-2-丙烯基硫酸酯可能会表现出有趣的特性,例如有机溶剂中的溶性以及不同条件下的稳定性.在处理该化合物时,应当注意安全防范,因为如果浸入或吸入,可能会对健康造成危害.

结构式图片

相似化合物

1659-31-0 1628-89-3 6231-18-1

欧盟法规

C&L通报

上下游产品

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合成工艺路线路线简述

  • 合成目标产物 Di-2-Pyridyl Thionocarbonate 主要起始原料 1-Butyl-3-Phenyl-2-Thiourea
  • 142-08-5 = 96989-50-3
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 5 Min,0 °C; 3 H,0 °C -> Rt
    标题:Differentiating Antiproliferative And Chemopreventive Modes Of Activity For Electron-Deficient Aryl Isothiocyanates Against Human Mcf-7 Cells
    作者:Anderson,Ruthellen H.; Lensing,Cody J.; Forred,Benjamin J.; Amolins,Michael W.; Aegerter,Cassandra L.; Et Al
    参考文献:Chemmedchem 日期:2018 卷标:13(16) 页码:1695-1710]

    = 96989-50-3 [标题:Reaction Conditions
    标题:Synthetic Applications Of Di-2-Pyridyl Thionocarbonate As A Dehydration,A Dehydrosulfurization,And A Thiocarbonyl Transfer Reagent
    作者:Kim,Sunggak; Yi,Kyu Yang
    参考文献:Bulletin Of The Korean Chemical Society 日期:1987 卷标:8(6) 页码:466-70]

    = 96989-50-3 [标题:Reaction Conditions
    标题:Terminally-Branched Polymeric Linkers Containing Extension Moieties For Prodrug Conjugates
    参考文献:United States]

    = 96989-50-3 [标题:Reaction Conditions
    标题:Novel Synthetic Reactions With 2-Pyridyl Related Reagents. A Review
    作者:Kim,Sunggak
    参考文献:Organic Preparations And Procedures International 日期:1988 卷标:20(1-2) 页码:145-72
📜1-丁基-3-苯基-2-硫脲置于4-二甲氨基吡啶 二吡啶硫碳酸酯,三乙胺体系中,用 二氯甲烷,乙腈 作为反应溶剂,化学反应 1.0H,反应生成 二吡啶硫碳酸酯
参考文献:硫代碳酸二-2-吡啶基酯.一种用于制备异硫氰酸酯和碳二亚胺的新试剂.
标题:硫代碳酸二-2-吡啶基酯.一种用于制备异硫氰酸酯和碳二亚胺的新试剂.
摘要:胺与二-2-吡啶基硫代碳酸酯在室温下反应可得到相应的异硫氰酸酯,而n,N'-二取代硫脲与二-2-吡啶基硫代碳酸酯在4-二甲基氨基吡啶存在下的反应可得到相应的异硫氰酸酯.碳二亚胺的收率很高.
DOI:10.1016/s0040-4039(00)98578-2

海关参考信息

专利信息


专利号:EP-1575929-B1
优先权日:2002-12-19
标 题 :The method for production of semi-finished products useful in synthesis of paclitaxel
发明人:KOLESINSKA BEATA; KAMINSKI J ZBIGNIEW; KAMINSKA E JANINA
权利人:AGROPHARM S A
摘要:The method for production of the semi-finished products useful in synthesis of Paclitaxel with the generalized formula (2), characterized in that phenyl isoserine derivatives, or mixtures of their epimerides with various configurations on the carbon 2' or their salts, are treated with triazine type condensing agent, possible in the presence of tertiary amine, in medium of anhydrous organic solvent, and the triazine esters produced are treated with Baccatin III, in medium of anhydrous organic solvent, possible in the presence of a catalyst.

专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:US-8062756-B2
优先权日:2005-08-26
标题:Stepwise growth of oligomeric redox-active molecules on a surface without the use of protecting groups
发明人:BOCIAN DAVID F; LINDSEY JONATHAN S; JIAO JIEYING
权利人:BOCIAN DAVID F; LINDSEY JONATHAN S; JIAO JIEYING; REGENTS OFT THE UNIVERSITY OF CALIFORNIA; UNIV NORTH CAROLINA STATE
摘要:This invention provides a procedure for growing oligomers via a stepwise process. The oligomers can include porphyrins, which have been previously shown to be attractive candidates for molecular-based information storage. The stepwise synthesis procedure requires no protecting groups, thus eliminating protection/deprotection reactions that add complexity to the process.

专利号:US-11186836-B2
优先权日:2016-06-16
标 题 :Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
发明人:WATTS RICHARD EDWARD
权利人:HAYSTACK SCIENCES CORP
摘要:The present disclosure relates to multifunctional molecules, including molecules according to formula (I):n n([(B 1 ) M -D-L 1 ] Y -H 1 ) O -G-(H 2 -[L 2 -E-(B 2 ) K ] W ) P ,   (I)n nwherein G, H 1 , H 2 , D, E, B 1 , B 2 , M, K, L 1 , L 2 , O, P, Y, and W are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional molecules to identify encoded molecules capable of binding target molecules.

专利号:US-2019169607-A1
优先权日:2016-06-16
标题:Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules

专利号:US-2007042401-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Mariarita Barone, Et Al. Synthesis And Biological Evaluation Of New Benzo-Thieno[3,2-D]Pyrimidin-4-One Sulphonamide Thio-Derivatives As Potential Selective Cyclooxygenase-2 Inhibitors. Mol Divers. 2013 Aug;17(3):445-58.

合成参考文献


摘要:Simmons, N.; Chheda, P.; Schuman, D., Science of Synthesis: DNA-Encoded Libraries, (2024) nan, 406.
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