CAS: 924-99-2; Ethyl 3-(Dimethylamino)Acrylate

相似化合物

1117-37-9 924-99-2 927-63-9

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专利信息

专利号:WO-2012100419-A1
优先权日:2011-01-26
标 题 :Process for synthesis of 3-(n,n-disubstituted-amino)-2- substituted acrylate
发明人：GU HAINING; LI XIAOLING; ZHANG PENGFEI; ZHANG XIKUN; CHEN LIANG
权利人:HANGZHOU GREAT FOREST BIOMEDICAL LTD; GU HAINING; LI XIAOLING; ZHANG PENGFEI; ZHANG XIKUN; CHEN LIANG
摘要:Disclosed is a process for synthesis of 3-(N,N-disubstituted-amino)-2-substituted acrylate, which comprises carrying out amine-substitution reaction and elimination reaction for 2-substituted formylacetate alkali metal salt represented by formula (III) and amine complex represented by formula (II) in organic solvent 1 to obtain 3-(N,N-disubstituted-amino)-2-substituted acrylate represented by formula (I). The process uses N,N-disubstituted amine and carbon dioxide, or a liquid complex obtained by N,N-disubstituted amine and carbon dioxide as raw material, thereby it doesn't produce a side product influencing environment. The process has the advantages of reacting simply and operating easily.

专利号:US-12252473-B2
优先权日:2022-04-18
标 题:Preparation methods of quinolone compounds and intermediates thereof
发明人：LEI JIE; CHEN ZHONGZHU; XU ZHIGANG; TANG DIANYONG; XU JIAYU; ZHOU HAOYI; XIA DANDAN; LIU YAO; CAO YIHUA; LUO JIE
权利人:UNIV CHONGQING ARTS & SCIENCES
摘要:The present application relates to processes for the preparation of quinolone compounds and intermediates thereof, particularly to processes for the preparation of quinolones and pharmaceutical intermediates of the quinolones. In particular, the present application provides a process for the preparation of a compound of Formula I, and a process for the synthesis of quinolone compounds using the compound of Formula I as an intermediate. The process for the preparation of the compound of Formula I comprises the steps of:reacting a compound of Formula A with R5NH2 and R6Cl in the presence of a base to form the compound of Formula I,

专利号:US-6835848-B1
优先权日:2000-03-07
标题:One-pot synthesis of alkyl 3-cyclopropylamino-2-[2,4-dibromo-3-(difluromethoxy) benzoyl]-2-propenoate as a useful intermediate for antibacterial quinolone medicaments
发明人：BOSE PROSENJIT; KUMAR NARESH; KIYOTO TARO
权利人:RANBAXY LAB LTD; TOYAMA CHEMICAL CO LTD
摘要:The present invention relates to a new and industrially advantageous one-pot process for the preparation of alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates of in which R represents methyl or ethyl, which are valuable intermediates for the production of highly active antibacterial quinolone medicaments.

专利号:US-9133188-B2
优先权日:2011-05-12
标题:Methods for preparing naphthyridines
发明人：PAUL DHARAM; HARVEY ANDREW JOHN; FLYNN BERNARD LUKE
权利人:PAUL DHARAM; HARVEY ANDREW JOHN; FLYNN BERNARD LUKE; BIONOMICS LTD
摘要:The present invention provides methods of synthesizing compounds of formula (1) and intermediates thereto. The present invention also provides intermediates useful in the synthesis of compounds of formula (1).

专利号:EP-1278717-B1
优先权日:2000-03-07
标题 :One-pot synthesis of alkyl 3-cyclopropylamino-2- 2,4-dibromo-3-(difluoromethoxy)benzoyl; -2-propenoate as a useful intermediate for antibacterial quinolone medicaments

专利号:US-2004267019-A1
优先权日:2000-03-07
标 题:One-pot synthesis of alkyl 3-cyclopropylamino -2-[2,4-dibromo-3-(difluromethoxy) benzoyl]-2-propenoate as a useful intermediate for antibacterial quinolone medicaments