CAS: 920-39-8; Isopropylmagnesium Bromide

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CAS号75-26-3 2-溴丙烷 | CAS号1071-39-2 di(propan-2-yl)... | CAS号10471-20-2 N,2-dimethyl-N-... | CAS号565-69-5 2-甲基-3-戊酮 | CAS号565-68-4 4-甲基-1-戊炔-3-醇 | CAS号14898-86-3 R-(+)-2-甲基-1-苯基-1-丙醇 | CAS号34857-28-8 (S)-2-甲基-1-苯基丙-1-醇 | CAS号565-67-3 2-甲基-3-戊醇 | CAS号623-37-0 3-己醇 | CAS号71-23-8 正丙醇 | CAS号3970-59-0 3-Pentanol, 3-e...

2-溴丙烷置于magnesium体系中,用 乙醚 作为反应溶剂,化学反应生成 异丙基溴化镁
参考文献:钛催化酯与脂肪族有机镁化合物环丙烷化的机理.四异丙醇钛存在下(Cd3)2Chmgbr与3-氯丙酸乙酯反应产物中氘的分布
标题:钛催化酯与脂肪族有机镁化合物环丙烷化的机理.四异丙醇钛存在下(Cd3)2Chmgbr与3-氯丙酸乙酯反应产物中氘的分布
摘要:(Cd3)2Chmgbr 与 3-氯丙酸乙酯在催化量的 Ti(Opr)4 存在下反应反应生成 (E)-1-(2-氯乙基)-3,3-Dideuterio-2-Trideuterio-Methylcyclopropanol 和(Cd3)2Cdh,通过质谱法鉴定.讨论了反应机理.
DOI:10.1007/bf02494693

专利信息

专利号:US-10011580-B2
优先权日:2016-04-21
标题:Diastereoselective synthesis of (±)-epianastrephin, (±)-anastrephin and analogs thereof
发明人：WALSE SPENCER S; KUZMICH DANIEL
权利人:US AGRICULTURE
摘要:A process for the synthesis of trans-fused γ-lactones having Formula (IV) from substituted cyclic ketones having Formula (I). A diastereoselective synthesis of (±)-epianastrephin (1) (wherein: R 1 is ethenyl, R 2 and R 3 is methyl, and n is 1), (±)-anastrephin (2) (wherein: R 2 is ethenyl, R 1 and R 3 is methyl and n is 1), and analogs thereof (wherein: R 1 is H, C 1-5 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, R 2 is H, C 1-5 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, R 1 and R 2 together with the carbon atom they are attached form a C 3-6 cycloalkyl ring, R 3 is C 1-5 alkyl and n is 0-2):

专利号:WO-9419366-A1
优先权日:1993-02-26
标题 :Chemical synthesis of squalamine
发明人：MORIARTY ROBERT M; GUO LIANG; TULADHAR SUDERSAN M
权利人:MAGAININ PHARMA
摘要:Methods for the chemical preparation or synthesis of the sterol antibiotic squalamine. Preferably, the preparation is by modifying the 3-position of a 3-oxo-7α-hydroxy-24z-ether protected alcohol group-5α-cholestane with a spermidino moiety to form a 3β-spermidino-7α-hydroxy-24z-ether protected group -5α-cholestane; deprotecting the 24-position of the 3β-spermidino-7α-hydroxy-24z-ether protected group-5α-cholestane to the free hydroxyl; and sulfating the 24-position of the 3β-spermidino-7α, 24-dihydroxy-5α-cholestane.

专利号:US-2010137659-A1
优先权日:2006-09-26
标题 :Process for the synthesis of 2,2',6-tribromobiphenyl
发明人：LEROUX FREDERIC; BONNAFOUX LAURENCE; COLOBERT FRANCOISE
权利人:LEROUX FREDERIC; BONNAFOUX LAURENCE; COLOBERT FRANCOISE
摘要:A process for the synthesis of 2,2′,6-tribromobiphenyl.

专利号:US-6814895-B2
优先权日:2000-12-20
标 题:Process for the synthesis of 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one
发明人：CVETOVICH RAYMOND; ASAI TOMOYUKI; YODOGAWA YOSHIKO
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one (CAS 30071-93-3). This compound is useful as an intermediate in the synthesis of therapeutic agents.

专利号:US-10626102-B2
优先权日:2015-12-30
标题 :Process for the synthesis of efinaconazol
发明人：VERONESE MARTINO; BETTONI PIERGIORGIO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of efinaconazole (I), starting from 1-[[(2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole and 4-methylenepiperidine, as free base or hydrochloride, in an organic solvent, under anhydrous conditions and in the presence of neutralising agents and reaction-promoting metal species. (1) The process is particularly advantageous because it gives rise to efinaconazole in high yields and purity, and uses little more than the stoichiometric amount of 4-methylenepiperidine, a rather expensive commercially available reagent.

专利号:US-4518813-A
优先权日:1981-10-02
标 题:Optically active units for the synthesis of the side chain of (R,R,R)-α-tocopherol and their preparation
发明人：ERNST HANSGEORG; VOGEL FRIEDRICH; PAUST JOACHIM
权利人:BASF AG
摘要:(2R,6R)-1-Chloro-2,6,10-trimethyl-undecane I, (R)-(+)-β-chloro-isobutyric acid II, (S)-(+)-1-bromo-3-chloro-2-methylpropane IV and (2R)-(+)-1-chloro-2,6-dimethyl-heptane V are novel optically active units for the synthesis of the side chain of (R,R,R)-α-tocopherol. In the process according to the invention, the optically active C 14 -chloride I is obtained in 6 simple reaction steps starting from II, via the novel intermediates IV and V, in accordance with the following equation: ##STR1##