CAS: 87447-47-0; (2S,3S)-2-(4-Methoxyphenyl)-4-Oxo-2,3,4,5-Tetrahydrobenzo[b][1,4]Thiazepin-3-Yl Acetate

该化合物是二氢化合物的衍生物,其特点是存在乙基氧功能组和甲氧替代体.该化合物可能由于存在一个可影响其生物活动和相互作用的立体中心而表现出有品性.乙基氧组表示潜在的再活动,允许进一步的化学修改或反应,而甲氧组则可能增强脂性并影响有机溶剂中的溶性.二氢化合物结构表明该化合物可能具有循环或部分饱和框架,有助于其稳定性和再活性.这种化合物往往因其独特的结构特征和功能组而发现药物或有机合成的中间体.了解具体特性,例如熔点,沸点和溶性,将需要实验数据或文献参考,以便全面了解其在各种化学环境中的行为.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

acetic anhydride (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one Acetic acid (2S,3S)-5-acetyl-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester N-t-B°C-didesmethyldiltiazem

合成工艺路线路线简述

  • 108-22-5 + 42399-49-5 = 87447-47-0
    反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: 1,4-Dioxane1.2 Reagents: Ammonia Solvents: Water
    标题:Some Applications Of Isopropenyl Acetate To O-,N- And C-Acetylation
    作者:Gizur,Tibor; Et Al
    参考文献:Synthetic Communications 日期:1990 卷标:20(15) 页码:2365-71]

    105560-93-8 = 87447-47-0
    反应条件:1.1 Catalysts: Iron Chloride (Fecl3) Solvents: Methanol,Toluene; 4 H,Reflux1.2 Catalysts: P-Toluenesulfonic Acid; 7 H,Reflux2.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Toluene; 2 H,Reflux
    标题:Biocatalytic Dynamic Reductive Kinetic Resolution Of Aryl α-Chloro β-Keto Esters: Divergent,Stereocontrolled Synthesis Of Diltiazem,Clentiazem,And Siratiazem
    作者:Yue,Xiaoping; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2022 卷标:58(64) 页码:9010-9013]

    78437-40-8 = 87447-47-0
    反应条件:1.1 Reagents: Glucose,Glutamate Dehydrogenase (Nadp) Solvents: Methanol,Water; 6 H,Ph 6.5,35 °C2.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Toluene; 1 H,Reflux3.1 Catalysts: Iron Chloride (Fecl3) Solvents: Methanol,Toluene; 4 H,Reflux3.2 Catalysts: P-Toluenesulfonic Acid; 7 H,Reflux4.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Toluene; 2 H,Reflux
    标题:Biocatalytic Dynamic Reductive Kinetic Resolution Of Aryl α-Chloro β-Keto Esters: Divergent,Stereocontrolled Synthesis Of Diltiazem,Clentiazem,And Siratiazem
    作者:Yue,Xiaoping; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2022 卷标:58(64) 页码:9010-9013]

    42399-41-7 = 87447-47-0 + 1643948-42-8
    反应条件:1.1 Reagents: Oxygen Catalysts: Cuprous Iodide Solvents: Dimethyl Sulfoxide; Rt -> 120 °C; 1 - 3 H,120 °C1.2 Reagents: Water
    标题:Access To Drug Metabolites Via C-H Functionalization: Copper-Catalyzed Aerobic Oxidation Of N,N-Dimethylalkylamines In Complex Pharmaceuticals
    作者:Genovino,Julien; Et Al
    参考文献:Tetrahedron Letters 日期:2015 卷标:56(23) 页码:3066-3069]

    42399-49-5 = 87447-47-0
    反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Toluene; 2 H,Reflux
    标题:Biocatalytic Dynamic Reductive Kinetic Resolution Of Aryl α-Chloro β-Keto Esters: Divergent,Stereocontrolled Synthesis Of Diltiazem,Clentiazem,And Siratiazem
    作者:Yue,Xiaoping; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2022 卷标:58(64) 页码:9010-9013]

    134931-62-7 = 87447-47-0
    反应条件:1.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Toluene; 1 H,Reflux2.1 Catalysts: Iron Chloride (Fecl3) Solvents: Methanol,Toluene; 4 H,Reflux2.2 Catalysts: P-Toluenesulfonic Acid; 7 H,Reflux3.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Toluene; 2 H,Reflux
    标题:Biocatalytic Dynamic Reductive Kinetic Resolution Of Aryl α-Chloro β-Keto Esters: Divergent,Stereocontrolled Synthesis Of Diltiazem,Clentiazem,And Siratiazem
    作者:Yue,Xiaoping; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2022 卷标:58(64) 页码:9010-9013]

    22027-50-5 = 87447-47-0
    反应条件:1.1 Reagents: Sulfuryl Chloride Solvents: 1,2-Dichloroethane; 2 H,Reflux; Cooled1.2 Reagents: Water; Cooled2.1 Reagents: Glucose,Glutamate Dehydrogenase (Nadp) Solvents: Methanol,Water; 6 H,Ph 6.5,35 °C3.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Toluene; 1 H,Reflux4.1 Catalysts: Iron Chloride (Fecl3) Solvents: Methanol,Toluene; 4 H,Reflux4.2 Catalysts: P-Toluenesulfonic Acid; 7 H,Reflux5.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Toluene; 2 H,Reflux
    标题:Biocatalytic Dynamic Reductive Kinetic Resolution Of Aryl α-Chloro β-Keto Esters: Divergent,Stereocontrolled Synthesis Of Diltiazem,Clentiazem,And Siratiazem
    作者:Yue,Xiaoping; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2022 卷标:58(64) 页码:9010-9013]

    100-06-1 = 87447-47-0
    反应条件:1.1 Reagents: Sodium Methoxide; 10 Min,Rt; 80 °C1.2 Solvents: Dimethyl Carbonate; 80 °C; 2 H,80 °C; Cooled1.3 Reagents: Hydrochloric Acid Solvents: Water; Neutralized2.1 Reagents: Sulfuryl Chloride Solvents: 1,2-Dichloroethane; 2 H,Reflux; Cooled2.2 Reagents: Water; Cooled3.1 Reagents: Glucose,Glutamate Dehydrogenase (Nadp) Solvents: Methanol,Water; 6 H,Ph 6.5,35 °C4.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Toluene; 1 H,Reflux5.1 Catalysts: Iron Chloride (Fecl3) Solvents: Methanol,Toluene; 4 H,Reflux5.2 Catalysts: P-Toluenesulfonic Acid; 7 H,Reflux6.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Toluene; 2 H,Reflux
    标题:Biocatalytic Dynamic Reductive Kinetic Resolution Of Aryl α-Chloro β-Keto Esters: Divergent,Stereocontrolled Synthesis Of Diltiazem,Clentiazem,And Siratiazem
    作者:Yue,Xiaoping; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2022 卷标:58(64) 页码:9010-9013
📜(2S-Cis)-(+)-2,3-二氢-3-羟基-2-(4-甲氧苯基)-1,5-苯并硫氮杂卓-4(5H)-酮置于ammonium Hydroxide,对甲苯磺酸体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 1.0H,反应生成 (2S-顺式)-3-(乙酰基氧基)-2,3-二氢-2-(4-甲氧基苯基)-1,5-苯并噻嗪革-4(5H)-酮
参考文献:Gizur,Tibor; Harsanyi,Kalman,Synthetic Communications,1990,Vol. 20,# 15,P. 2365-2371
标题:Gizur,Tibor; Harsanyi,Kalman,Synthetic Communications,1990,Vol. 20,# 15,P. 2365-2371

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合成参考文献


摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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