CAS: 86010-68-6; N-((4-Fluorophenyl)Methyl)Ethanamide

该化合物是一种有机化合物,其特征为氨化物功能组,由碳基(C=O)与氮原子(N)相连. 4-氟联苯组的存在表明,氟联苯原子被替换在苯环的副位置上,有助于该化合物独特的电子和...

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CAS号64-19-7 冰醋酸 | CAS号140-75-0 对氟苄胺 | CAS号459-56-3 对氟苯甲醇 | CAS号75-05-8 乙腈 | CAS号75-36-5 乙酰氯 | CAS号352-32-9 对氟甲苯

合成工艺路线路线简述

  • 合成目标产物 N-((4-Fluorophenyl)Methyl)Ethanamide 主要起始原料 Acetic Anhydride And 4-Fluorobenzylamine
  • 60-35-5 + 459-57-4 = 86010-68-6
    反应条件:1.1 Reagents: Carbon Monoxide Catalysts: Rhodium Solvents: Diethyl Ether; 22 H,40 Bar,150 °C
    标题:Reductive Amidation Without An External Hydrogen Source Using Rhodium On Carbon Matrix As A Catalyst
    作者:Tsygankov,Alexey A.; Makarova,Maria; Afanasyev,Oleg I.; Kashin,Alexey S.; Naumkin,Alexander V.; Et Al
    参考文献:Chemcatchem 日期:2020 卷标:12(1) 页码:112-117]

    140-75-0 = 86010-68-6
    反应条件:1.1 Reagents: Water Catalysts: Silica (Sulfuric Acid),Sulfuric Acid (Silica); 12 H,140 °C
    标题:Silica Sulfuric Acid Mediated Acylation Of Amines With 1,3-Diketones Via C-C Bond Cleavage Under Solvent-Free Conditions
    作者:Guo,Ruiqiang; Zhu,Chuanlei; Sheng,Zhe; Li,Yanzhe; Yin,Wei; Et Al
    参考文献:Tetrahedron Letters 日期:2015 卷标:56(45) 页码:6223-6226]

    127-19-5 + 140-75-0 = 86010-68-6
    反应条件:1.1 Reagents: Ammonium Chloride; Rt -> 166 °C; 3 H,166 °C
    标题:A Novel Synthesis Process Of Acetanilide
    作者:Yi,Maocong; Mao,Wutao; Wang,Jianhui
    参考文献:Huaxue Yu Shengwu Gongcheng 日期:2011 卷标:28(12) 页码:56-58]

    140-75-0 = 86010-68-6
    反应条件:1.1 Solvents: Water; Rt; 9 Min,Rt
    标题:Catalyst/ Surfactant Free Chemoselective Acylation Of Amines In Water
    作者:Dulla,Balakrishna; Vijayavardhini,Suryadevara; Rambau,Dandela; Anuradha,Vegendla; Rao,Mandava V. B.; Et Al
    参考文献:Current Green Chemistry 日期:2014 卷标:1(1) 页码:73-79]

    60-35-5 + 459-57-4 = 86010-68-6
    反应条件:1.1 Reagents: Carbon Monoxide Catalysts: Dirhodium Tetraacetate Solvents: Tetrahydrofuran; 22 H,30 Atm,140 °C
    标题:Dichotomy Of Atom-Economical Hydrogen-Free Reductive Amidation Vs Exhaustive Reductive Amination
    作者:Kolesnikov,Pavel N.; Usanov,Dmitry L.; Muratov,Karim M.; Chusov,Denis
    参考文献:Organic Letters 日期:2017 卷标:19(20) 页码:5657-5660]

    60-35-5 + 140-75-0 = 86010-68-6
    反应条件:1.1 Catalysts: Iron Oxide (Fe3O4); 1 H,140 °C
    标题:Transamidation Catalysed By A Magnetically Separable Fe3O4 Nano Catalyst Under Solvent-Free Conditions
    作者:Thale,Pranila B.; Borase,Pravin N.; Shankarling,Ganapati S.
    参考文献:Rsc Advances 日期:2016 卷标:6(58) 页码:52724-52728]

    140-75-0 = 86010-68-6
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 5 Min,0 °C1.2 5 H,0 °C -> Rt
    标题:Distal Meta-Alkenylation Of Formal Amines Enabled By Catalytic Use Of Hydrogen-Bonding Anionic Ligands
    作者:Goswami,Nupur; Sinha,Soumya Kumar; Mondal,Partha; Adhya,S.; Datta,Ayan; Et Al
    参考文献:Chem 日期:2023 卷标:9(4) 页码:989-1003
📜对氟苯甲醇 反应生成 N-((4-氟苯基)甲基)乙酰胺
参考文献:Shine Henry J.,Yueh Wang,J. Org. Chem,59 (1994) N 13,S 3553-3559
标题:Shine Henry J.,Yueh Wang,J. Org. Chem,59 (1994) N 13,S 3553-3559

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专利信息


专利号:WO-2017156194-A1
优先权日:2016-03-08
标题:Compositions and methods for inhibiting influenza rna polymerase pa endonuclease
发明人：PUERTA DAVID T; COHEN SETH M; CREDILLE CY V
权利人:UNIV CALIFORNIA; PUERTA DAVID T
摘要:There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.

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合成参考文献


摘要:Galczynski, J.; Huang, H.; Lambert, T. H., Science of Synthesis: Special Topics, (2021) 1, 350.
摘要:Dong, X.; Qin, H.; Chen, Y., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .
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