专利号:WO-2007094533-A1 优先权日:2006-02-17 标题:Composition for inhibiting collagen degradation and promoting collagen synthesis comprising emodin 发明人:PARK DEOK HOON; LEE JONG SUNG; JUNG EUN SUN; HYUN CHANG GU; HONG SEONG TAEK 权利人:BIOSPECTRUM INC; PARK DEOK HOON; LEE JONG SUNG; JUNG EUN SUN; HYUN CHANG GU; HONG SEONG TAEK 摘要:Disclosed is a composition, comprising emodin, for inhibiting collagen degradation and promoting collagen synthesis. The composition stimulates cell regeneration by promoting the synthesis of collagen by normal fibroblasts, alleviates wrinkles, and imparts the skin with elasticity. Also, the composition can be used as a preparation for external use for skin, such as cosmetics.
专利号:EP-1119635-B1 优先权日:1998-10-09 标 题 :Non-homogeneous systems for the resolution of enantiomeric mixtures 发明人:YAO YIMING; WANG YI FONG; ALMOND MERRICK R 权利人:ALTHEA TECHNOLOGIES INC; GILEAD SCIENCES INC 摘要:The present invention relates to a process for the biocatalyst-mediated enantioselective conversion of enantiomeric mixtures of hydrophobic esters using a biphasic solvent system. More particularly, the present invention relates to the enzyme-mediated enantioselective synthesis of anti-viral compounds, such as 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane (FTC) and its analogues, in a non-homogeneous reaction system.
专利号:US-11655342-B2 优先权日:2019-12-31 标 题 :Modified polymethylhydrosiloxane, terminal modified conjugated diene-vinyl aromatic hydrocarbon copolymer and synthesis method for which, rubber composition and tire 发明人:HSIEH KUAN-LIN 权利人:CHI MEI CORP; CHIMEI CORP 摘要:A modified polymethylhydrosiloxane, a terminal modified conjugated diene-vinyl aromatic hydrocarbon copolymer and a synthesis method for which, a rubber composition and a tire are provided. The modified polymethylhydrosiloxane includes a compound represented by a formula (1). n nE is a moiety containing an epoxide group. T is a moiety containing an alkoxysilylalkyl group. A is selected from the group consisting of hydrogen, a moiety containing an alkyl group and a moiety containing an amino group. B is a moiety containing an aryl group. G is a moiety containing an ethyleneoxy group and an alkoxy group. J is a moiety containing an ethyleneoxy group and a hydroxyl group. e=5-45. t=1-4. a+b+g+j is equal to 1 to 595.
专利号:US-5512648-A 优先权日:1986-04-30 标 题:Polyamide resin-protide conjugate, preparation and uses 发明人:SPARROW JAMES T; KNEIB-CORDONIER NANCY; KANDA PATRICK; LANFORD ROBERT E 权利人:SPARROW JAMES; KANDA PATRICK; BAYLOR COLLEGE MEDICINE 摘要:A large pore polyamide resin is useful for large peptide and protein (protide) synthesis. A method of preparing the same comprises mixing a dimethylacrylamide monomer with an unsaturated or alkenoyl amine monomer, a cross-linker and water, homogeneously emulsifying the aqueous mixture with an organic solvent in the presence of an emulsifier, adjusting the pH of the aqueous mixture during polymerization to 6-8.5 to produce large pore resin beads, and isolating the beads. The beads may be used as a solid phase substrate for the synthesis of a polyamide/protide conjugate. The polyamide resin/protide conjugate may be used, without separation of the protide from the resin or subsequent purification, for immunizing mammals, including humans, against the protide, for affinity purifying immunological molecules binding to the protide, and for immunoassays.
专利号:US-5084509-A 优先权日:1986-04-30 标题:Polyamide bound protide, method of use thereof and kit 发明人:SPARROW JAMES T; KANDA PATRICK; KENNEDY RONALD C 权利人:BAYLOR COLLEGE MEDICINE 摘要:A polyamide resin for use in peptide and protein synthesis, and a method of preparing and using same. The polyamide resin is prepared by mixing a dimethylacrylamide monomer with an N-acrylyl-diaminoalkane functional monomer in an aqueous solution together with a cross-linker and emulsifying the aqueous solution in an organic solvent. An initiator and a promoter are added to polymerize the N-acrylyl-diaminoalkane functional monomer, dimethylacrylamide monomer, and cross-linker in the form of beads. The pH of the mixture is controlled during the polymerization. The beads are used as a solid phase for peptide and protein synthesis according to methods known in the art. The conjugate of the polyamide resin and the synthesized peptide or protein is used directly for immunoassays or immunization without the need for separation of the peptide or protein from the resin and subsequent purification.
专利号:WO-2011158333-A1 优先权日:2010-06-15 标题 :Zederone analogue and method for synthesizing same 发明人:SUETSUGU KAZUHIRO; MORITA SATOSHI; YAMADA YASUHIRO; OHNO TOSHINOBU; ITO TAKATOSHI; IWAI TOSHIYUKI; MATSUMOTO FUKASHI 权利人:NARIS COSMETICS CO LTD; OSAKA MUNICIPAL TECH RES INST; SUETSUGU KAZUHIRO; MORITA SATOSHI; YAMADA YASUHIRO; OHNO TOSHINOBU; ITO TAKATOSHI; IWAI TOSHIYUKI; MATSUMOTO FUKASHI 摘要:The present invention provides a method for synthesizing a zederone analogue derived from natural materials, a precursor useful in synthesis of the zederone analogue, and an intermediate useful for synthesizing the zederone precursor. Specifically, the present invention uses (E) -5-halegeno-4-hexanoic acid alkyl ester as a starting material to synthesize a zederone analogue, a precursor useful in synthesis of the zederone analogue, and an intermediate useful for synthesizing the zederone precursor.
1: Guarneri F, Corazza M, Stingeni L, Patruno C, Napolitano M, Pigatto PDM, Gallo R, Cristaudo A, Romita P, Offidani A, Schena D, Milanesi N, Micali G, Zucca M, Caterina F; SIDAPA Study Group. Myroxylon pereirae (Balsam of Peru): still worth testing? Contact Dermatitis. 2021 Mar 21. doi: 10.1111/cod.13839. Epub ahead of print. 104(3):184-186. 81(6):454-456. doi: 10.1111/cod.13359. Epub 2019 Jul 31. 81(3):221-225. doi: 10.1111/cod.13332. Epub 2019 Jun 27. 30(6):632-637. doi: 10.1111/pai.13069. Epub 2019 Jun 28. 80(4):241-242. doi: 10.1111/cod.13179. Epub 2019 Jan 10. 76(6):378-379. doi: 10.1111/cod.12765. 44(6):e113-e114. doi: 10.1111/1346-8138.13731. Epub 2017 Feb 2. a rare cause of contact allergy in consecutively patch tested dermatitis patients. Contact Dermatitis. 2016 Apr;74(4):242-5. doi: 10.1111/cod.12536. Epub 2016 Jan 25. 73(5):296-304. doi: 10.1111/cod.12468. Epub 2015 Aug 28. 69(5):313-5. doi: 10.1111/cod.12090. 455(1-2):259-66. doi: 10.1016/j.ijpharm.2013.07.022. Epub 2013 Jul 19. 39(11):1809-17. doi: 10.3109/03639045.2012.738682. Epub 2013 Jan 2. 23(4):158-61. doi: 10.1097/DER.0b013e318260d75f. 29(3):266-72. doi: 10.1016/j.clindermatol.2010.11.004. 377(1-2):135-41. doi: 10.1016/j.ijpharm.2009.03.024. Epub 2009 Apr 1. 379(1):1-8. doi: 10.1016/j.ijpharm.2009.05.066. Epub 2009 Jun 6. 37(3-4):284-90. doi: 10.1016/j.ejps.2009.02.015. Epub 2009 Mar 6. 7(6):541-3. English, German. doi: 10.1111/j.1610-0387.2009.07031.x. Epub 2009 Feb 10.
合成参考文献
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