CAS: 79-64-1; (6S,8R,9S,10R,13S,14S,17S)-17-Hydroxy-6,10,13-Trimethyl-17-Prop-1-Ynyl-2,6,7,8,9,11,12,14,15,16-Decahydro-1H-Cyclopenta[a]Phenanthren-3-One

该化合物是一种合成蛋白质,主要用于荷尔蒙疗法和避孕药具,其特点是能够模仿天然蛋白质的动作,从而影响与月经周期和妊娠有关的各种生理过程;二硝基苯酯的化学结构包括一种典型的类固醇脊柱,典型的是种状腺,其特征是处于特定位置的两个甲基组,增强了它的威力和稳定性;该化合物以其口服生物利用率而著称,并经常与雌激素结合用于激素替代疗法;二硝基酯展示抗色素特性,使其有效地治疗内分泌素和某些类型月经紊乱等情况;其药性效应包括调节月经周期,预防排卵和保持妊娠;然而,与其他荷尔蒙制剂一样,它可能会产生副作用,包括对情绪和心血管健康的潜在影响;与任何药物一样,其使用应当由保健专业人员指导,考虑到个人健康概况和潜在反作用.

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上下游产品

H-chol-5-en-20-yne-3β,17-diol6-methyl-21,24-dinor-17βH-chol-5-en-20-yne-3β,17-diol H-chol-20-yn-3-one5,17-dihydroxy-6β-methyl-21,24-dinor-5α,17βH-chol-20-yn-3-one H-chol-5-en-20-yne-3β,17-diol21,24-dinor-17βH-chol-5-en-20-yne-3β,17-diol H-pregn-5-en-20-yne-3β,17-diol6-methyl-17βH-pregn-5-en-20-yne-3β,17-diol

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    专利信息


    专利号:US-8017776-B2
    优先权日:2003-07-15
    标题 :Methods for synthesis of acyloxyalkyl compounds
    发明人：BHAT LAXMINARAYAN; GALLOP MARK A
    权利人:XENOPORT INC
    摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

    专利号:US-8143437-B2
    优先权日:2002-02-19
    标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
    发明人：GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X
    权利人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X; XENOPORT INC
    摘要:The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.

    专利号:US-2005239725-A1
    优先权日:2002-02-19
    标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof

    专利号:US-2005070715-A1
    优先权日:2003-07-15
    标 题:Methods for synthesis of acyloxyalkyl compounds

    专利号:US-7560483-B2
    优先权日:2002-02-19
    标题 :Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof

    专利号:US-7662987-B2
    优先权日:2003-07-15
    标题:Methods for synthesis of acyloxyalkyl compounds

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    主要参考文献


    1: Dimethisterone. Med Actual. 1968;4(1):7-9.
    21:377-85. 3(1-2):167-77. doi: 10.1080/15287397709529556. 16(1):15-27. doi: 10.1016/s0039-128x(70)80092-7.
    104:57-72.

    合成参考文献


    参考文献:10.1056/nejm198003063021004
    摘要:Weiss NS, Sayvetz TA. Incidence of endometrial cancer in relation to the use of oral contraceptives. N Engl J Med. 1980 Mar 06;302(10):551–4. doi: 10.1056/nejm198003063021004.
    参考文献:10.1056/nejm198003063021010
    摘要:Cole P. Oral contraceptives and endometrial cancer. N Engl J Med. 1980 Mar 06;302(10):575–6. doi: 10.1056/nejm198003063021010.
    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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