CAS: 73692-50-9; 3-(4-Hydroxyphenyl)-1-(2,4,6-Trihydroxyphenyl)Prop-2-En-1-One

该化合物是氟芳烃化合物,其特点是其铬结构,由三碳,不饱和碳基系统连接的两个芳香环组成,这一特殊化合物有四个氢氧(-OH)组,分别位于2欧元,4欧元, 4欧元和6欧元的芳香圈位置,有助于其潜在的抗氧化特性.它通常是黄色晶体固体,有机溶剂中可溶解,并且由于存在多种氢氧基组,在水中表现出中等溶解性.该化合物在各个领域,包括药理学和食品科学方面,都令人感兴趣,因为它具有潜在的健康利益,例如抗炎和抗微生物活动.此外,其结构特征允许它参与各种化学反应,使它成为合成有机化学的一种有价值的化合物.与许多氟芳类一样,其生物活动可能受到其结构结构结构的影响,使其成为对天然产品化学进行持续研究的主体.

结构式图片

上下游产品

2'-Hydroxy-4,4',6'-Trimethoxymethoxylchalcone 118075-12-0
2,4,6-三羟基苯乙酮一水合物 2,4,6-Trihydroxyacetophenone 480-66-0

合成工艺路线路线简述

    📜2'-Hydroxy-4,4',6'-Trimethoxymethoxylchalcone置于盐酸体系中,用 甲醇 作为反应溶剂,化学反应 0.25H,以79%的收率获得产物2',4,4',6'-四羟基查耳酮
    参考文献:一类a环具有甲基的醌式查尔酮化合物,制法 与抗炎活性
    标题:一类a环具有甲基的醌式查尔酮化合物,制法 与抗炎活性
    摘要:本发明公开了一类a环具有甲基的醌式查尔酮类化合物及其制备方法与抗炎活性应用.本发明的化合物具有通式(ⅰ)所示的结构,其制备方法包括以下步骤:(1)合成2‑羟基‑4,6‑二甲氧甲氧基苯乙酮,(2)合成2'‑羟基‑4',6'‑二甲氧甲氧基查尔酮衍生物,(3)合成2',4',6'‑三羟基查尔酮衍生物,(4)合成一类a环具有甲基的醌式查尔酮类化合物.本发明的化合物制备方法简单并且具有明显的抗炎作用.

    海关参考信息

    专利信息


    专利号:US-5043328-A
    优先权日:1986-05-09
    标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems
    发明人:WEITHMANN KLAUS U
    权利人:HOECHST AG
    摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.

    专利号:US-2008311580-A1
    优先权日:2004-03-09
    标 题:Novel genes encoding proteins involved in proanthocyanidin synthesis
    发明人:ABRAHAMS SHARON; ASHTON ANTHONY RICHARD; TANNER GREGORY JOHN; LARKIN PHILIP JOHN
    权利人:COMMW SCIENT IND RES ORG
    摘要:This inventions provides an isolated protein or polypeptide having activity in the synthesis of proanthocyanidin (PA) polymer from epicatechin or catechin in plants, and which is not naturally regulated by the TT2 or TT8 regulators, or a fragment comprising at least about 10 contiguous amino acids derived from said protein or polypeptide, particularly TDS1, TDS2, TDS3, TDS4, TDS5, or TDS6 protein, or fragment thereof. n Also provided are nucleic acid encoding such proteins or polypeptides; plant cells and plants containing and expressing such nucleic acids; antibodies that bind to such proteins or polypeptides; and related methods.

    专利号:US-2014033370-A1
    优先权日:2010-12-09
    标题 :Visual screening for enzymes on the phenylpropanoid pathway
    发明人:ABELIOVICH HAGAI; ALBERSTEIN MOTI
    权利人:ABELIOVICH HAGAI; ALBERSTEIN MOTI; YISSUEM RES DEV COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    摘要:The invention relates to a method to screen for a nucleic acid molecule encoding a polypeptide involved in the synthesis of naringenin chalcone which demonstrates altered expression, activity or substrate specificity. The invention further relates to nucleic acid molecules identified by said screen and to transgenic plants modified to express said nucleic acid molecule.

    专利号:US-6051383-A
    优先权日:1995-06-26
    标题:Sequences for production of 2,4-diacetylphloroglucinol and methods
    发明人:THOMASHOW LINDA S; BANGERA MAHALAXMI; WELLER DAVID M; COOK R JAMES
    权利人:US AGRICULTURE; UNIV WASHINGTON
    摘要:DNA sequences which function specifically in the synthesis of 2,4-diacetylphloroglucinol (Phl) are described. The sequences include phl genes which encode phl gene proteins and coding and regulatory sequences for production of Phl as well as sequences containing phl genes, which sequences have the capability of conferring or enhancing Phl biosynthetic capability in bacterial strains. The transformed strains are useful as biocontrol agents against fungal pathogens.

    专利号:US-4113755-A
    优先权日:1977-05-18
    标题 :Synthesis of prostaglandin precursors
    发明人:LAROCK RICHARD C
    权利人:UNIV IOWA STATE RES FOUND
    摘要:A process of making prostaglandin precursors by reacting bicyclic or polycyclic olefins with an alkenylmercuric salt, in the presence of a noble metal salt to provide a cis, beta-alkenyl bicyclic alkyl noble metal salt.

    专利号:US-2019276389-A1
    优先权日:2015-12-18
    标题:Synthesis of aryl cyclohexane ester derivatives useful as sensates in consumer products
    发明人:WOS JOHN AUGUST; YELM KENNETH EDWARD; BUNKE GREGORY MARK; FREDERICK HEATH ALAN; REILLY MICHAEL; HAUGHT JOHN CHRISTIAN; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
    权利人:PROCTER & GAMBLE
    摘要:Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Kong D, Li S, Smolke CD. Discovery of a previously unknown biosynthetic capacity of naringenin chalcone synthase by heterologous expression of a tomato gene cluster in yeast. Sci Adv. 2020 Oct 30;6(44):eabd1143. doi: 10.1126/sciadv.abd1143.
    2: Liu Y, Liu J, Wang R, Sun H, Li M, Strappe P, Zhou Z. Analysis of secondary metabolites induced by yellowing process for understanding rice yellowing mechanism. Food Chem. 2021 Apr 16;342:128204. doi: 10.1016/j.foodchem.2020.128204. Epub 2020 Sep 28. 21(1):734. doi: 10.1186/s12864-020-07133-5.
    4: Ayuso-Calles M, García-Estévez I, Jiménez-Gómez A, Flores-Félix JD, Escribano-Bailón MT, Rivas R. Rhizobium laguerreae Improves Productivity and Phenolic Compound Content of Lettuce (Lactuca sativa L.) under Saline Stress Conditions. Foods. 2020 Aug 24;9(9):1166. doi: 10.3390/foods9091166.

    合成参考文献


    参考文献:10.1093/jxb/err216
    摘要:Ohno S, Hosokawa M, Hoshino A, Kitamura Y, Morita Y, Park KI, Nakashima A, Deguchi A, Tatsuzawa F, Doi M, Iida S, Yazawa S. A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). J Exp Bot. 2011 Oct;62(14):5105–16.
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