CAS: 704-41-6; 1-Ethynyl-2-(Trifluoromethyl)Benzene

上下游产品

CAS号88444-77-3 1-(2,2-dichloro... | CAS号79756-82-4 1-(1,2-dibromoe... | CAS号444-29-1 2-碘三氟甲苯 | CAS号79756-81-3 ALFA-甲基-2-三氟甲基苄醇 | CAS号395-45-9 邻三氟甲基苯乙烯 | CAS号3796-19-8 2-trifluorometh... | CAS号392-83-6 邻溴三氟甲苯 | CAS号98-08-8 三氟甲苯 | CAS号74423-01-1 o-ethyl-α,α,α-t... | CAS号395-45-9 邻三氟甲基苯乙烯 | CAS号1294009-25-8 2-三氟甲基苯乙烯硼酸频哪醇酯 | CAS号17408-14-9 2'-(三氟甲基)苯乙酮 | CAS号841205-62-7 methyl 3-[2-(tr...

📜邻溴三氟甲苯置于正丁基锂体系中,用 乙醚 作为反应溶剂,化学反应 2.4H,反应生成 2-乙炔基-α,α,α-三氟甲苯
参考文献:Preparation Of Fluorine-Containing Phenylacetylenes By The Method Of Introduction Of The Ethynyl Group Using 1,1-Dichloro-2,2-Difluoroethene
标题:Preparation Of Fluorine-Containing Phenylacetylenes By The Method Of Introduction Of The Ethynyl Group Using 1,1-Dichloro-2,2-Difluoroethene
摘要:具有氟或三氟甲基取代基的苯乙炔(arc≡ch)(邻,间,对位氟;邻,间,对位cf3;2,4-,2,5-,2,6-,3,5-双(Cf3)2)已通过溴苯(arbr)和苯(arh)与1,1-二氯-2,2-二氟乙烯(1)的两步路线制备得到:Arli或armgbr->arcf=ccl2->arc≡cli.在-70oc下仔细处理时,邻氟苯基锂以非常好产率反应生成邻fc6H4Cf=ccl2,同时伴随苯炔衍生的产物,如邻(邻fc6H4)C6H4Cf=ccl2.在0oc下对间双(三氟甲基)苯进行9小时(24小时)的锂化,随后用溴处理,分别以35(38)%,31(36)%和8(6)%的收率获得产物1-溴-2,4-,2,6-和3,5-双(三氟甲基)苯.
DOI:10.1246/bcsj.61.1625

专利信息

专利号:US-8697862-B2
优先权日:2008-05-16
标题 :Synthesis of galactoside inhibitors
发明人：NILSSON ULF
权利人:NILSSON ULF; GALECTO BIOTECH AB
摘要:Novel synthesis routes for preparation of thiodigalactosides and intermediates are presented. The method includes the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corresponding thiol in situ, which in turn is directly reacted with a 3-azido-galactosyl bromide resulting in the 3,3′-di-azido-thio-di-galactoside before the thiol has a chance to reduce the azido 10 group. Hence, in situ formation of the 3-azido-galactosyl thiol from the thiouronium salt is essential in the synthesis procedure, because any other method that generate the thiol separately results in extensive unwanted azide reduction.

专利号:US-9284336-B1
优先权日:2014-08-21
标题 :Synthesis of 4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate and analogs
发明人：LAALI KENNETH K
权利人:LAALI KENNETH K; UNIV NORTH FLORIDA
摘要:4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate salt was synthesized and isolated. The pentafluorosulfanyl salt was examined in a wide assortment of reactions to form novel SF 5 -bearing alkenes, alkynes, and biaryl derivatives using Heck-Matsuda, Sonogashira, and Suzuki coupling protocols. Dediazoniation of the salt furnished the corresponding p-SF 5 —C 6 H 4 X, C 6 H 4 OS(O)(CF 3 )â•?NSO 2 CF 3 , and p-SF 5 —C 6 H 4 —NTf 2 derivatives. The azide derivative p-SF 5 —C 6 H 4 N 3 entered into click chemistry with phenylacetylenes to furnish the corresponding triazoles. Various SF 5 -bearing alkenes were synthesized by coupling reactions using a metal catalyst. Fluorodediazoniation selectively furnished the fluoro derivative p-SF 5 —C 6 H 4 F. Homolytic dediazoniation gave the unsymmetrical biaryls, thus demonstrating the broad utility of pentafluorosulfanyl diazonium salts as building blocks of SF5-aromatics that are in high demand in many branches of chemistry including biomedicine and materials chemistry.

专利号:US-6121495-A
优先权日:1995-09-12
标题:Ethynyl substituted aromatic compounds, synthesis, polymers and uses thereof
发明人：BABB DAVID A; SMITH JR DENNIS W; MARTIN STEVEN J; GODSCHALX JAMES P
权利人:DOW CHEMICAL CO
摘要:Compounds of ethynyl aromatic compounds form polymers which have high thermal stability. The monomers are useful for coating a wide variety of substances such as dielectric coatings where high thermal resistance is desirable including electronic components such as computer chips.

专利号:WO-2009139719-A9
优先权日:2008-05-16
标 题 :Novel synthesis of galactoside inhibitors

专利号:US-2011130553-A1
优先权日:2008-05-16
标题 :Novel synthesis of galactoside inhibitors

专利号:US-2014011765-A1
优先权日:2008-05-16
标题:Novel synthesis of galactoside inhibitors