CAS: 676-83-5; Methyldichlorophosphine

📜氯甲烷置于aluminum (Iii) Chloride,三氯化磷体系中,85.0 °C,1.5 Mpa 条件下,反应 8.0H,以85%的收率获得产物甲基二氯膦
参考文献:一种草铵膦中间体甲基二氯化磷的合成方法
标题:一种草铵膦中间体甲基二氯化磷的合成方法
摘要:本发明公开一种草铵膦中间体甲基二氯化磷的合成方法,属于草铵膦中间体合成技术领域.该合成方法是以氯甲烷,三氯化铝和三氯化磷为原料,在0.5‑3.0Mpa压力下反应6.5‑10H得到三元络合物,再加入铝粉和氯化钠,在一定温度下反应得到甲基二氯化磷.本发明方法中,三氯化磷同时作为反应物和溶剂,并提高反应压强,使氯甲烷气体与固,液两相充分反应,不需要另外加入溶剂,提高了产品纯度,避免了溶剂分离,回收等问题,减少了三氯化磷回收难度,大大降低了生产成本.

专利信息

专利号:US-5936080-A
优先权日:1996-05-24
标题 :Compositions and methods for the synthesis of organophosphorus derivatives
发明人：STEC WOJCIECH J; WOZNIAK LUCYNA
权利人:GENTA INC; POLSKA AKADEMIA NAUK INSTYTUT
摘要:New organophosphorus mononucleoside derivatives, methods of their synthesis and methods for the synthesis of organophosphorus dinucleotide derivatives utilizing the organophosphorus mononucleosides are provided. Synthesized organophosphorus mononucleoside derivatives of the present invention are characterized by the formula; ##STR1## Organophosphorus dinucleoside derivatives prepared from the synthesis methods provided in the present invention are characterized by the formula; ##STR2##

专利号:US-5856465-A
优先权日:1996-05-24
标 题:Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
发明人：STEC WOJCIECH JACEK; WOZNIAK LUCYNA
权利人:POLSKA AKAD NAUK CENTRUM
摘要:Methods for the stereospecific synthesis of chirally pure organophosphorus dinucleotide derivatives and nucleoside monomer synthons used in their synthesis are provided. These methods allow for conversion of nucleoside intermediates of unchosen sense of P-chirality to nucleoside monomer synthons of chosen sense of P-chirality. Also provided are novel nucleoside intermediates useful in such methods.

专利号:EP-0850248-B1
优先权日:1995-09-01
标 题 :Compositions and methods for the synthesis of organophosphorus derivatives
发明人：STEC WOJCIECH J; WOZNIAK LUCYNA
权利人:POLSKA AKAD NAUK CENTRUM
摘要:Methods for the stereospecific synthesis of chirally pure organophosphorus dinucleotide derivatives and nucleoside monomer synthons used in their synthesis are provided. These methods allow for conversion of nucleoside intermediates of unchosen sense of P-chirality to nucleoside monomer synthons of chosen sense of P-chirality. Also provided are novel nucleoside intermediates useful in such methods.

专利号:EP-0828749-B1
优先权日:1995-05-26
标题 :Methods for the synthesis of organophosphorus derivatives
发明人：STEC WOJCIECH J; WOZNIAK LUCYNA; RILEY TIMOTHY
权利人:GENTA INC; POLSKA AKADEMIA NAUK INSTYTUT
摘要:New organophosphorus mononucleoside derivatives, method of their synthesis and methods for the synthesis of organophosphorus dinucleotide derivatives utilizing the organophosphorus mononucleoside derivatives are provided. Synthesized organophosphorus mononucleoside derivatives of the present invention are characterized by formula (1).

专利号:EP-0901500-B1
优先权日:1996-05-03
标题:In situ preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides
发明人：ZHANG ZHAODA; TANG JIN-YAN
权利人:AVECIA BIOTECHNOLOGY INC
摘要:The invention provides novel bifunctional phosphitylating reagents and their application in in situ preparation of 5'-protected nucleoside phosphoramidites and synthesis of oligonucleotides. Bifunctional phosphitylating reagents according to the invention react quickly with nucleosides under weakly acidic conditions. In addition, the bifunctional phosphitylating reagents according to the invention generate chemoselectively the corresponding nucleoside phosphoramidites in situ, without need to purify the nucleoside phosphoramidites before using them in oligonucleotide synthesis. Finally, the bifunctional phosphitylating reagents according to the invention are relatively stable and easy to handle.

专利号:US-6407223-B1
优先权日:1997-04-25
标 题 :Process for the synthesis of modified P-chiral nucleotide analogues
发明人：STEC WOJCIECH J; WOZNIAK LUCYNA A; CHWOROS ARKADIUSZ; PYZOWSKI JAROSLAW
权利人:POLSKA AKADEMIA NAUK CENIRUM B
摘要:The process of the instant invention is drawn to the synthesis of modified P-chiral nucleotide analogues in the form of pure diastereomers possessing preselected configuration at the P-atom. Oligonucleotides prepared by the method of the invention containing P-chiral compounds have enhanced hybridization and transporting properties.