CAS: 63466-71-7; Benzo[a]Pyrene-D12

该化合物是一种以致癌特性而闻名的多环芳烃(PAH),是一种被分离的苯并(a) 丙烯-D12,是一种以其致癌特性而闻名的苯并(a) 丙烯烃."D12"称分子中十二个氢原子已被分子的除子(一种稳定的氢同位素)所取代,这增强了氢在分析化学中的效用,特别是在追踪和量化研究中.该化合物通常被用作质量光谱测量和其他分析技术的内部标准,以提高苯并(a) 苯并(a) 苯并(a) 苯并(a) 苯并(pyrenne) 测量的精确性.本佐(a) 苯并(a) 在室内温度下是固体,具有较高的熔点和低溶液在水中,但可溶解于有机溶剂中.其结构由五根结合的芳香环组成,有助于其在环境中的稳定性和持久性.由于其潜在的健康风险,包括诱导性和致癌性和致癌性,因此在实验室环境中会谨慎地处理,并遵守减少接触的安全议定书.

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1520-96-3 1718-52-1 1719-03-5

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    主要参考文献

    [参考文献]: Russak Em, Et Al. Impact Of Deuterium Substitution On The Pharmacokinetics Of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
    [参考文献]: Saeko Onami, Et Al. Dosimetry For Lung Tumorigenesis Induced By Urethane, 4-(N-Methyl-N-Nitrosamino)-1-(3-Pyridyl)-1-Butanone (Nnk), And Benzo[参考文献]: Yeo Cd, Et Al. Roflumilast Treatment Inhibits Lung Carcinogenesis In Benzo(A)Pyrene-Induced Murine Lung Cancer Model. Eur J Pharmacol. 2017 Oct 5812:189
    [参考文献]: Badreddine Barhoumi, Et Al. Pollution Biomonitoring In The Bizerte Lagoon (Tunisia), Using Combined Chemical And Biomarker Analyses In Grass Goby, Zosterisessor Ophiocephalus (Teleostei, Gobiidae). Mar Environ Res. 2014 Oct:101:184-195.
    [参考文献]: Inyang O Oyo-Ita, Et Al. Distribution And Sources Of Petroleum Hydrocarbons In Recent Sediments Of The Imo River, Se Nigeria. Arch Environ Contam Toxicol. 2016 Feb;70(2):372-82.

    合成参考文献


    参考文献:10.1007/s10661-014-3800-z
    摘要:Benson NU, Essien JP, Asuquo FE, Eritobor AL. Occurrence and distribution of polycyclic aromatic hydrocarbons in surface microlayer and subsurface seawater of Lagos Lagoon, Nigeria. Environmental Monitoring and Assessment. 2014 May 24;186(9):5519–29. doi: 10.1007/s10661-014-3800-z.
    参考文献:10.1007/s00244-015-0228-6
    摘要:Echols BS, Smith A, Gardinali P, Rand G. An Evaluation of Select Test Variables Potentially Affecting Acute Oil Toxicity. Archives of Environmental Contamination and Toxicology. 2015 Oct 14;70(2):392–405. doi: 10.1007/s00244-015-0228-6.
    参考文献:10.1007/s00216-008-2182-x
    摘要:Bergvall C, Westerholm R. Determination of 252–302 Da and tentative identification of 316–376 Da polycyclic aromatic hydrocarbons in Standard Reference Materials 1649a Urban Dust and 1650b and 2975 Diesel Particulate Matter by accelerated solvent extraction–HPLC-GC-MS. Analytical and Bioanalytical Chemistry. 2008 Jun 03;391(6):2235–48. doi: 10.1007/s00216-008-2182-x.
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