CAS: 63405-88-9; (4-Amino-2-Methylphenyl)Methanol

该化合物是一种多种芳香酒精衍生物,主要有矿物质和氢氧化甲基功能组,其分子结构以电子施放和反应场所为特点,在有机合成中具有作为中间体的价值,特别是在染料,药品和特殊化学品的生产中. 化合物的矿物质组通过二亚化或凝聚反应进一步发挥作用,而氢氧化甲基组则提供了洗涤或氧化的机会. 高纯度等级确保了精细化学应用的一贯性. 在受控条件下和定义明确的再活性剖面有助于其在需要精确分子修改的研究和工业过程中的效用.

英文名称(4-Amino-2-Methylphenyl)Methanol
中文名称(4-氨基-2-甲基苯基)甲醇
IUPAC名称(4-amino-2-methylphenyl)methanol
其它别名2-甲基-4-氨基苯甲醇; 4-Amino-2-Methylbenzyl Alcohol
CAS编号63405-88-9
MFCD编号:MFCD11110504
分子式:C8H11NO分子量:137.18
产品CID: 2533416
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: DZLYWPKCBRSMIB-UHFFFAOYSA-N
InChI=1S/C8H11NO/c1-6-4-8(9)3-2-7(6)5-10/h2-4,10H,5,9H2,1H3
计算化学: 氢键受体数2.0氢键供体数2可旋转键数1

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

formaldehyd m-toluidine hydr°Chloride 4-nitro-o-xylene 4-amino-2-methylbenzaldehyde4-(acetylamino)-2-methylphenyl acetate 4-(acetylamino)-5-bromo-2-methylbenzyl acetate N-[4-(acetyloxymethyl)-2-cyano-5-methylphenyl]-acetamide

合成工艺路线路线简述

📜4-硝基邻二甲苯置于甲醇,Sodium Tetrahydroborate体系中,化学反应生成 (4-氨基-2-甲基苯基)甲醇
参考文献:Chemical Development Of Zd9331: Synthesis Of A Bromomethylquinazolinone Avoiding A Nonselective Radical Bromination
标题:Chemical Development Of Zd9331: Synthesis Of A Bromomethylquinazolinone Avoiding A Nonselective Radical Bromination
摘要:An Efficient Regiospecific Synthesis Of Zd9331 Pivaloyloxymethyl (Pom) Bromide (4) Has Been Accomplished Via Zd9331 Quinacetate Hcl (15) Avoiding A Nonselective Bromination. The Original Route Used A Radical Bromination On A Substrate With Three Methyl Groups,Which Generated A Range Of Bromomethyl Derived Compounds That Carried Through To The Final Active Pharmaceutical Ingredient (Api). A Strategy,Based On The Zinin Reaction,Was Developed To Synthesize The Required Bromomethyl Compound In A Regioselective Manner. This Approach Was Successfully Scaled To Manufacture A Tonne Of Material.
DOI:10.1021/op060049A