CAS: 6304-89-8; 3-Acetoxybenzoic Acid

上下游产品

(3R,4S,5R)-3,4,5-triacetoxycyclohex-1-ene-1-carboxylic acid acetic anhydride 3-Carboxyphenol acetyl chloride 3-Methoxybenzoic acid 3-acetoxy-benzoic acid-anhydride 3-(chlor°Carbonyl)phenyl acetate Cyclohexanecarboxylic acid

📜乙酸间甲苯酯置于cobalt(II) Acetate,Manganese(II) Acetate 偶氮二异丁腈,氧气,1,3,5-三羟基-1,3,5-三嗪-2,4,6(1H,3H,5H)-三酮体系中,用 溶剂黄146 作为反应溶剂,100.0 °C,101.32 Kpa 条件下,反应 14.0H,以75%的收率获得产物间乙酰苯甲酸
参考文献:在n,N',N'-三羟基异氰尿酸作为关键催化剂的存在下,用分子氧氧化取代的甲苯.
标题:在n,N',N'-三羟基异氰尿酸作为关键催化剂的存在下,用分子氧氧化取代的甲苯.
摘要:发现n,N',N''-三羟基异烟酰胺酸(thica)是用二氧氧化烷基苯的非常有效的催化剂.因此,在thica(5 Mol%)和co(oac)存在的情况下,在o(2)(1 Atm)下,各种带有吸电子取代基的间位和对位取代甲苯,例如氰基甲苯,氯甲苯和甲苯酸)(2)(0.5 Mol%)在100摄氏度下几乎以定量收率平滑地氧化为相应的苯甲酸.比较了thica和n-羟基邻苯二甲酰亚胺对甲苯的需氧氧化.在温和的条件下,对甲苯被thica有效地高产率(超过95%)氧化为对苯二甲酸.
DOI:10.1021/jo034313Z

专利信息

专利号:US-8481501-B2
优先权日:2004-05-28
标 题 :Synthesis of metabolically stable analgesics, pain medications and other agents
发明人：CASHMAN JOHN R; MACDOUGALL JAMES M
权利人:CASHMAN JOHN R; MACDOUGALL JAMES M; HUMAN BIOMOLECULAR RES INST
摘要:Disclosed are analgesic-related compositions and methods of using the compositions for modulation of analgesic receptor activity. The compositions and methods are useful for reducing pain, as well as for therapeutic intervention of addictions or other diseases or disorders amenable to treatment or prophylaxis by modulation of analgesic receptor signaling.

专利号:AU-2005249508-A1
优先权日:2004-05-28
标题 :Synthesis of metabolically stable analgesics, pain medications and other agents

专利号:WO-2005117589-A1
优先权日:2004-05-28
标题:Synthesis of metabolically stable analgesics, pain medications and other agents

专利号:JP-2008501036-A
优先权日:2004-05-28
标题 :Metabolic stable analgesics, pain pharmacotherapy and synthesis of other substances

专利号:JP-2012254984-A
优先权日:2004-05-28
标题 :Metabolic stable analgesics, pain pharmacotherapy and synthesis of other substances

专利号:EP-1758452-A4
优先权日:2004-05-28
标题:SYNTHESIS OF METABOLIC STABLE ANALGETICS, DISEASES OF MEDICAMENTS AND OTHER ACTIVE SUBSTANCES