CAS: 6099-04-3; 3-(3-Methoxyphenyl)Acrylic Acid

上下游产品

CAS号141-82-2 丙二酸 | CAS号591-31-1 3-甲氧基苯甲醛 | CAS号100-83-4 间羟基苯甲醛 | CAS号65152-37-6 4t-(3-methoxy-p... | CAS号33877-04-2 trans-1-ethoxyc... | CAS号186581-53-3 重氮甲烷 | CAS号14755-02-3 3-羟基肉桂酸; 间羟基肉桂酸 | CAS号6771-54-6 3-Methoxybenzyl... | CAS号5111-70-6 5-甲氧基-1-茚酮 | CAS号40138-66-7 3-(3-甲氧基苯基)丙醛 | CAS号178678-16-5 (S)-N-[2-(2,3-二... | CAS号591-31-1 3-甲氧基苯甲醛 | CAS号28495-76-3 2,4(1H,3H)-Pyri... | CAS号28495-90-1 4(1H)-Pyrimidin... | CAS号6500-65-8 2-甲氧基苯并环庚-5-酮 | CAS号626-20-0 3-甲氧基苯乙烯 | CAS号5309-19-3 8-甲氧基-β-四氢萘酮 | CAS号68208-19-5 β-(3-甲氧基)苯丙氨酸

<3-Methoxy-Benzyliden>-Malonsaeure 反应生成 3-甲氧基肉桂酸
参考文献:Bauer; Vogel,Journal Fur Praktische Chemie (Leipzig 1954),1913,Vol. <2> 88,P. 340
标题:Bauer; Vogel,Journal Fur Praktische Chemie (Leipzig 1954),1913,Vol. <2> 88,P. 340

专利信息

专利号:US-4189583-A
优先权日:1978-04-26
标题 :Synthesis of 4A-aryl-decahydroisoquinolines
发明人：GLESS RICHARD D; RAPOPORT HENRY; WELLER DWIGHT D
权利人:U S OF AMERICA HEW SECRETARY
摘要:This invention relates to a process for the production of 4a-aryldecahydroisoquinolines where the aryl group is selected as 3-methoxy phenyl. These compounds are morphine analogs and show utility similar to the known morphine, codeine, and thebaine. In this process particular novelty is asserted for the production of a nipecotic ester ethyl 4-(3'-methoxyphenyl)-1-methyl piperidine-3-carboxylate. Furthermore, novelty is asserted for the step of conversion of the nipecotates through cyclization to cis- or trans-tert-butyl 1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyldecahydroisoquinoline-7-carboxylate, which may also be easily converted to the keto amide, trans-1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyldecahydroisoquinoline.

专利号:WO-2012089181-A1
优先权日:2010-12-30
标题 :O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same
发明人：VLASAKOVA RUZENA; HAJICEK JOSEF; ZEZULA JOSEF
权利人:ZENTIVA KS; VLASAKOVA RUZENA; HAJICEK JOSEF; ZEZULA JOSEF
摘要:The compounds of general formula II are new and represent important intermediates in the synthesis of tapentadol. In the synthesis of tapentadol of formula I and its pharmaceutically acceptable salts, O-protected (2R,3R)-acids of general formula II, in step A, are reacted in an inert organic solvent with an activating agent, optionally in presence of a catalyst or a base; in step B, the obtained compounds of general formula V, wherein R has the above mentioned meaning and X stands for chlorine or alkoxycarbonyloxyl group O-CO-OR 1 or pivaloyloxyl O-CO-t-Bu group, wherein R 1 is methyl or ethyl, are reacted with dimethylamine or its salts optionally in presence of a base; in step C, the obtained N, N-dimethylamides of general formula VI, wherein R has the above mentioned meaning, are reduced by means of hydride agents in a suitable solvent; in step D, the produced alkeneamines of general formula VII, wherein R has the above mentioned meaning, are hydrogenated on a metal catalysts in a suitable solvent; and, finally, in step E, the produced alkaneamines of general formula VIII, wherein R has the above mentioned meaning, are O-dealkylated by means of dealkylating agents, and, if required, the obtained tapentadol is converted by the action of a pharmaceutically acceptable acid to respective salts, e.g. hydrochloride.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-4435572-A
优先权日:1978-04-26
标题:Synthesis of ethyl-4(3'-methoxyphenyl)-1-methyl piperidine-3-carboxylate
发明人：RAPOPORT HENRY; WELLER DWIGHT D; CLESS RICHARD D
权利人:US HEALTH
摘要:This invention relates to a process for the production of 4a-aryldecahydroisoquinolines where the aryl group is selected as 3-methoxy phenyl. These compounds are morphine analogs and show utility similar to the known morphine, codeine, and thebaine. In this process particular novelty is asserted for the production of a nipecotic ester ethyl 4-(3'-methoxyphenyl)-1-methyl piperidine-3-carboxylate. Furthermore, novelty is asserted for the step of conversion of the nipecotates through cyclization to cis- or trans-tert-butyl 1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyldecahydroisoquinoline-7-carboxylate, which may also be easily converted to the keto amide, trans-1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyldecahydroisoquinoline.

专利号:US-5608074-A
优先权日:1993-12-03
标 题:Process for the synthesis of 5-amino tetrazole derivatives
发明人：WALKER JONATHAN
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides is described where a cinnamic acid is converted in the presence of thionyl chloride and a 4-N,N'-disubstituted aminopyridine in one step to the desired product.

专利号:US-7632972-B2
优先权日:2003-10-30
标 题 :Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells
发明人：HERGENROTHER PAUL J; NESTERENKO VITALIY; PUTT KARSON; ALLEN BRITTANY JOY; DOTHAGER ROBIN SHANE; LESLIE BENJAMIN JAMES
权利人:UNIV ALABAMA
摘要:Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. The generation of synthetic combinatorial libraries and the evaluation of library member compounds regarding induction of apoptosis selectively in cancer cells are disclosed. Compounds, methods of making the compounds, and therapeutic methods with application against breast cancer cells, melanoma cancer cells, colon cancer cells, and other cancer cells are described.