CAS: 58-58-2; (S)-2-Amino-N-((2S,3S,4R,5R)-5-(6-(Dimethylamino)-9H-Purin-9-yl)-4-Hydroxy-2-(Hydroxymethyl)Tetrahydrofuran-3-yl)-3-(4-Methoxyphenyl)Propanamide Dihydrochloride

专利信息

专利号:US-2023398215-A1
优先权日:2020-10-28
标 题:Genetically engineered antigen-specific natural killer cells for in situ synthesis of proteins
发明人：BHATNAGAR PARIJAT
权利人:STANFORD RES INST INT
摘要:An example genetically engineered natural killer (NK) cell comprises an exogenous polynucleotide sequence that includes a receptor element, an actuator element, and an effector element. The receptor element encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen binding domain recognizes a surface antigen of a target cell. The actuator element encodes a transcription factor binding site that upregulates synthesis of an effector protein. The effector element encodes the effector protein operably linked to a signal peptide, wherein, in response to the antigen binding domain of the CAR binding to the antigen of the target cell, the engineered NK cell is configured to activate and, to synthesize and secrete the effector protein.

专利号:US-11672829-B2
优先权日:2015-09-10
标 题:Genetically engineered coronavirus-specific effector cells for in situ synthesis of antiviral proteins
发明人：BHATNAGAR PARIJAT; SSEMADAALI MARVIN A
权利人:STANFORD RES INST INT
摘要:An example genetically engineered effector cell comprises an exogenous polynucleotide sequence that includes a receptor element, an actuator element, and an effector element. The receptor element encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen binding domain recognizes an antigen on a surface of a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-infected cell. The actuator element encodes a transcription factor binding site that upregulates synthesis of an antiviral protein. The effector element encodes the antiviral protein operably linked to a signal peptide, wherein, in response to the antigen binding domain of the CAR binding to the antigen of SARS-CoV-2-infected cell, the engineered effector cell is configured to activate and, to synthesize and secrete the antiviral protein.

专利号:US-2024101632-A1
优先权日:2021-01-27
标 题:Genetically engineered electrically-stimulated effector cells for in situ synthesis of proteins
发明人：BHATNAGAR PARIJAT; NEWMYER SHERRI
权利人:STANFORD RES INST INT
摘要:An example genetically engineered electrically-stimulated (ES) cell comprises an exogenous polynucleotide sequence that includes an electrical-sensor element, an actuator element, and an effector element. The electrical-sensor element encodes a voltage-gated calcium ion channel (CaV), wherein the CaV is configured to transition from a closed state to an open state in response to stimulation. The actuator element encodes a transcription factor binding site that upregulates synthesis of an effector protein. The effector element encodes the effector protein, wherein, in response to the transition of the CaV to the open state, the genetically engineered ES effector cell is configured to activate and, to synthesize and secrete the effector protein.

专利号:WO-2024206300-A1
优先权日:2023-03-27
标题 :Synthesis of a hippo-yap pathway modulator and a polymorph thereof
发明人：KONRADI ANDREI W; WILSON JO ANN ZBUR; ZELLER JAMES ROBERT
权利人:VIVACE THERAPEUTICS INC
摘要:Described herein is the preparation of a Hippo-YAP pathway modulator and chemical intermediates used in the synthetic process. Also described herein is a polymorph of a Hippo-YAP pathway modulator.

专利号:US-2024285670-A1
优先权日:2021-06-11
标题 :Therapeutic treatment of tumors by blocking the heme synthesis-export axis
发明人：TOLOSANO EMANUELA; FIORITO VERONICA; PETRILLO SARA; CHIABRANDO DEBORAH; ALLOCCO ANNA LUCIA; BERTINO FRANCESCA
权利人:UNIV DEGLI STUDI DI TORINO
摘要:A blocker of heme synthesis-export axis as active agent for use in the treatment of a tumor in a subject, wherein the blocker of heme synthesis-export axis upmodulates oxidative metabolism of tumor cells by upregulating the tricarboxylic acid (TCA) cycle and the oxidative phosphorylation (OXPHOS).

专利号:WO-2022165079-A1
优先权日:2021-01-27
标 题 :Genetically engineered electrically-stimulated effector cells for in situ synthesis of proteins