CAS: 57455-06-8; 3-Iodobenzyl Alcohol

该化合物是一种卤代芳香醇,通常用作有机合成的多用途中间体,其主要优点包括稳定的异丁基结构,有利于交叉反应,核生殖替代和制药衍生的选择性功能化;氢氧基组增强极溶剂的溶解性,使多步骤合成能够高效处理;该化合物因其与铃木-宫浦等催化反应的兼容性,在药用化学中特别受重视,用于制造复杂的分子;高纯度能确保研究和工业应用的再生性;在惰性条件下的适当储存保持其活性和储存稳定性.

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CAS号197093-23-5 (3-(1H-吡唑-3-基)苯基)甲醇 | CAS号864068-80-4 (3-(1H-吡唑-1-基)苯基)甲醇 | CAS号696-41-3 3-碘苯甲醛 | CAS号618-91-7 3-碘苯甲酸甲酯 | CAS号60076-09-7 间碘氯苄 | CAS号68034-75-3 3-(3-碘苯基)丙酸 | CAS号103669-00-7 3-(2-噻吩基)苄醇 | CAS号126485-58-3 3-(3-甲氧基苯基)苯甲醛 | CAS号620-24-6 3-羟基苯甲醇 | CAS号20854-56-2 (4-甲氧基联苯-3-基)-甲醇

合成工艺路线路线简述

    3-碘苯甲酸甲酯置于二异丁基氢化铝体系中,化学反应生成 3-碘苯甲醇
    参考文献:聚合物负载的碘代苯的新型制备及其作为间氯过苯甲酸可循环使用的试剂的合成效用
    标题:聚合物负载的碘代苯的新型制备及其作为间氯过苯甲酸可循环使用的试剂的合成效用
    摘要:三种新型聚合物负载的碘苯化合物a 0,A 6和a 10从可商购的交联聚(的反应制备p氯甲基)苯乙烯与米-Iodobenzylalcohol,6-(米-Iodobenzyloxy)-1-己醇和10-(米-Iodobenzyloxy)-1-癸醇.它们对酮的氧化α-对甲苯磺酰和的环化催化活性和可重用性ñ在存在甲氧基-2-Arylethanesulfonamides米氯过苯甲酸(米cpba)被证实提供α-Tosyloxyketones和ñ-甲氧基-3,4-二氢-2,1-苯并噻嗪-2,2-二氧化物的收率很高. 聚合物支撑的φ-再循环米cpba-α-Tosyloxyketone-酮-ñ-甲氧基-3,4-二氢-2,1-苯并噻嗪2,2-二氧化物-催化剂
    DOI:10.1055/s-0029-1218795

    海关参考信息

    专利信息


    专利号:US-7109377-B2
    优先权日:1996-10-16
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
    发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
    权利人:HARVARD COLLEGE
    摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

    专利号:WO-0006525-A9
    优先权日:1998-07-25
    标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

    专利号:WO-0006525-A2
    优先权日:1998-07-25
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

    专利号:US-10053423-B2
    优先权日:2014-01-03
    标 题:Radioiodinated compounds
    发明人:DIMAGNO STEPHEN; HU BAO
    权利人:NUTECH VENTURES
    摘要:This disclosure relates to reagents and methods useful in the synthesis of aryl iodines, for example, in the preparation of iodine labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.

    专利号:US-8198432-B2
    优先权日:2005-02-25
    标题:Porphyrin-based compounds for tumor imaging and photodynamic therapy
    发明人:PANDEY RAVINDRA K; SAJJAD MUNAWWAR; PANDEY SURESH; GRYSHUK AMY; OSEROFF ALLAN; PINCUS LEGAL REPRESENTATIVE STEPHANIE; NABI HANI A
    权利人:PANDEY RAVINDRA K; SAJJAD MUNAWWAR; PANDEY SURESH; GRYSHUK AMY; OSEROFF ALLAN; PINCUS LEGAL REPRESENTATIVE STEPHANIE; NABI HANI A; HEALTH RESEARCH INC; RES FOUNDATION SUNY
    摘要:This invention describes a first report on the synthesis of certain 124 I-labelled photosensitizers related to chlorines and bacteriochlorins with long wavelength absorption in the range of 660-800 nm. In preliminary studies, these compounds show a great potential for tumor detection by positron emission tomography (PET) and treatment by photodynamic therapy (PDT). The development of tumor imaging or improved photodynamic therapy agent(s) itself represent an important step, but a dual function agent (PET imaging and PDT) provides the potential for diagnostic body scan followed by targeted therapy.

    专利号:US-6448443-B1
    优先权日:1996-10-16
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
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    主要参考文献

    [参考文献]: Beatrice Felber, Et Al. Dendritic Metalloporphyrins With A Distal H-Bond Donor As Mimics Of Haemoglobin. Org Biomol Chem. 2003 Apr 7;1(7):1090-3.
    [参考文献]: G Vaidyanathan, Et Al. Radiolabeled Guanine Derivatives For The In Vivo Mapping Of O(6)-Alkylguanine-Dna Alkyltransferase: 6-(4-[(18)F]Fluoro-Benzyloxy)-9H-Purin-2-Ylamine And 6-(3-[(131)I]Iodo-Benzyloxy)-9H-Purin-2-Ylamine. Bioconjug Chem. 2000 Nov-Dec;11(6):868-75.

    合成参考文献


    摘要:Black, D. A.; Fagnou, K., Science of Synthesis, (2010) 45, 591.
    摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 79.
    摘要:Denmark, S.; Chang, W.-T. T., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 396.
    摘要:Chartoire, A.; Nolan, S. P., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 519.
    摘要:Denmark, S.; Chang, W.-T. T., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 456.
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