CAS: 544-62-7; 3-(Octadecyloxy)Propane-1,2-Diol

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十八烷基甲烷磺酸酯置于盐酸,氢氧化钾体系中,用 甲醇,二甲基亚砜 作为反应溶剂,化学反应生成 鲨肝醇
参考文献:N-Het-Substituted Glycerophosphoethanolamines
标题:N-Het-Substituted Glycerophosphoethanolamines
摘要:本发明涉及一种新颖的具有治疗活性的脂肪烷基和烯基醚甘油磷酸醇胺,其在乙醇胺氮上带有杂环环取代基,以及使用该化合物及其药学上可接受的盐的方法,以及含有它们的制药组合物.该发明的新颖,具有治疗活性的化合物和盐具有抗肿瘤,抗银屑病,抗炎和paf拮抗活性.

专利信息

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-5681971-A
优先权日:1994-12-12
标题 :Synthesis of fatty N-alkyl amides
发明人：SCHEIBEL JEFFREY JOHN; SHUMATE ROBERT EDWARD
权利人:PROCTER & GAMBLE
摘要:Fatty N-alkyl amides are synthesized directly from glycerides (preferably triglycerides) and amines in the absence of a catalyst, and preferably without a solvent. The method provides for products suitable for use without further purification, preferably after separating the glycerol and amide products. The disclosed method is also useful for the synthesis of glycerol from glycerides and ammonia and/or primary amines.

专利号:US-9267090-B2
优先权日:2009-07-07
标 题:Synthesis of biolubricant esters from unsaturated fatty acid derivatives
发明人：ELOMARI SALEH ALI; MILLER STEPHEN JOSEPH; ZHOU ZHEN
权利人:ELOMARI SALEH ALI; MILLER STEPHEN JOSEPH; ZHOU ZHEN; CHEVRON USA INC
摘要:The present invention is generally directed to diester-based lubricant compositions comprising one or more isomeric mixtures of diester species. The present invention is also directed to methods of making these and other similar lubricant compositions. In some embodiments, the methods for making such diester-based lubricants utilize a biomass precursor material from which mono-unsaturated free lipid species can be provided or otherwise generated, wherein such mono-unsaturated free lipid species are converted to isomeric diol species en route to the synthesis of diester species for use as/in the diester-based lubricant compositions.

专利号:US-2013053592-A1
优先权日:2011-08-31
标题 :Fatty acids as co-catalysts in preparation of glycerides from ethyl esters
发明人：SAEBO ASGEIR
权利人:SAEBO ASGEIR; PHARMA MARINE AS
摘要:Methods of producing concentrates of omega-3 fatty acid ethyl esters, from an ethyl ester composition comprising use of free fatty acids as co-catalysts for enzymatic synthesis of partial glycerides are provided. In some embodiments, methods of producing concentrates of ethyl-eicosapentanoate and/or ethyl-docosahexanoate from an ethyl ester composition containing the esters comprise a) adding glycerol, an immobilized enzyme catalyst, and a free fatty acid co-catalyst b) allow glyceryl ester synthesis to proceed by adjustment of temperatures, time and vacuum such that a substantial amount of partial glycerides is formed and c) separating an ethyl ester fraction enriched in ethyl eicosanoate and ethyl docosahexanoate from the glyceride mixture.

专利号:US-4983750-A
优先权日:1988-08-06
标题 :Phosphobetaines, methods for their synthesis and their use especially for industrial purposes
发明人：GIERSBERG JOACHIM; KOLLMEIER HANS-JOACHIM
权利人:GOLDSCHMIDT AG TH
摘要:Phosphobetaines of the general formula ##STR1## are disclosed in which R 1 is an alkyl group with 1 to 20 carbon atoms, optionally substituted with OH groups, or the ##STR2## group, in which R 6 is a divalent alkylene group with 1 to 10 carbon atoms, optionally substituted with OH group, n R 2 is a divalent hydrocarbon group with 2 to 10 carbon atoms, the chain of which may be interrupted by one or more nitrogen atoms, n R 1 , R 5 are the same or different and represent alkyl or benzyl groups and n R 4 is an alkyl group with 1 to 4 carbon atoms. n Also disclosed is the synthesis of these compounds and their use as surface active substances, preferably for the treatment of polar surfaces in the industrial area.

专利号:US-7091369-B2
优先权日:2003-07-15
标题:Synthesis of polyconjugated fatty acids
发明人：SMITH WILLIAM; KUKLEV DMITRY V
权利人:UNIV MICHIGAN STATE
摘要:The present invention relates to fatty acids. In particular, the present invention provides polyconjugated fatty acids, and methods of their synthesis and their use.