CAS: 533-68-6; Ethyl 2-Bromobutanoate

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上下游产品

CAS号52089-54-0 2-羟基丁酸乙酯 | CAS号64-17-5 乙醇 | CAS号26074-52-2 2-溴丁酰溴 | CAS号104165-34-6 3-ethyloxirane-... | CAS号80-58-0 2-溴丁酸 | CAS号541-41-3 氯甲酸乙酯 | CAS号141-75-3 丁酰氯 | CAS号107-92-6 正丁酸 | CAS号141-97-9 乙酰乙酸乙酯 | CAS号75-03-6 碘乙烷 | CAS号56674-69-2 2-甲氧基丁酸 | CAS号607-97-6 2-乙基乙酰乙酸乙酯 | CAS号90485-52-2 3-乙基哌嗪-2-酮 | CAS号3724-65-0 巴豆酸 | CAS号56674-70-5 α-methoxybutyri... | CAS号600-15-7 DL-2-羟基丁酸 | CAS号924-97-0 4-羰基庚酸 | CAS号17145-91-4 2-膦酰丁酸三乙脂 | CAS号495-40-9 苯丁酮 | CAS号194470-85-4 ethyl 2-[bis(2,...

2-羟基正丁酸乙酯置于咪唑,溴,三苯基膦体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 2-溴丁酸乙酯
参考文献:镍催化的烷基卤化物根岸交叉偶联,包括未活化的叔卤化物,与硼稳定的有机锌试剂
标题:镍催化的烷基卤化物根岸交叉偶联,包括未活化的叔卤化物,与硼稳定的有机锌试剂
摘要:未活化的叔烷基亲电子试剂与烷基金属试剂的镍催化交叉偶联仍然是一个挑战.我们在此报告了镍催化的烷基卤化物(包括未活化的叔卤化物)与硼稳定的有机锌试剂 Bpinch 2 Zni 的根岸交叉偶联,产生具有高官能团耐受性的多功能有机硼产品.重要的是,发现 Bpin 基团对于进入季碳中心是必不可少的.制备的季有机硼酸盐的合成实用性通过它们转化为其他有用的化合物来证明.
DOI:10.1021/acs.Orglett.3C00051

专利信息

专利号:US-6849650-B2
优先权日:1998-02-27
标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6399628-B1
优先权日:1996-11-22
标 题 :N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting alpha- amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; FOLMER BEVERLY K; JOHN VARGHESE; LATIMER LEE H; NISSEN JEFFREY S; REEL JON K; THORSETT EUGENE D; WHITESITT CELIA A
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:EP-0951466-B1
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：WU JING; TUNG JAY S; THORSETT EUGENE D; PLEISS MICHAEL A; NISSEN JEFFREY S; NEITZ JEFFREY; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; DROSTE JAMES J; HENRY STEVEN S; MCDANIEL STACEY L; SCOTT WILLIAM L; STUCKY RUSSELL D
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds for Formula (I) wherein the substituents are as defined in the claims which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-9452425-B2
优先权日:2002-09-26
标 题 :Compositions containing ionic liquids and their uses, in particular in organic synthesis
发明人：VAULTIER MICHEL; GMOUH SAID
权利人:VAULTIER MICHEL; GMOUH SAID; CENTRE NAT RECH SCIENT; UNIV RENNES
摘要:An ionic liquid is used as liquid matrix for organic synthesis in homogeneous phase on soluble support, the ionic liquid being presented in liquid or solid form at ambient temperature, of formula A 1 + X 1 − , A 1 + representing a cation, functional or non-functional, or a mixture of cations in which either none of the cations is functional or at least one of the cations is functional, and X 1 − an anion, functional or non-functional, or a mixture of anions in which either none of the anions is functional or at least one of the anions is functional.

专利号:US-4234744-A
优先权日:1978-12-18
标 题 :Process for the production of aminoacid hydrochlorides/or diaminoacid dihydrochlorides
发明人：EFFENBERGER FRANZ; DRAUZ KARLHEINZ
权利人:DEGUSSA
摘要:Aminoacid hydrochlorides or diaminoacid dihydrochlorides are produced by first reacting a halocarboxylic acid ester with an alkali metal cyanate in the presence of an alcohol to form the corresponding mono- or diurethane and then saponifying this to the corresponding mono- or dihydrochloride. The new process is relatively versatile in its use and above all opens up an elegant synthesis route for lysine.